Ageing and plasma Coenzyme Q10 status

age-and-coq10-status-graph-large
Dr. Judy analyzed the data from 5000 healthy adult volunteers. The data showed that, through the course of their lives, approximately 13% (green) of the volunteers had low plasma Coenzyme Q10 status, nearly 75% (blue) had medium plasma Coenzyme Q10 status, and only 12% (red) had high Coenzyme Q10 status. Conclusion: fully 88% of healthy adults, starting in their 30s and 40s, could benefit from a daily Coenzyme Q10 supplement.

As with so many other things in life, “normal” as in normal Coenzyme Q10 status is a topic about which reasonable people can reasonably disagree.  The range for normal Coenzyme Q10 status, measured in plasma or in serum, is relatively wide and can vary according to a number of factors: age, diet, fitness level, gender, heredity, and nature of work activity.

Plasma Coenzyme Q10 normally distributed
As far as we know, the distribution of human Coenzyme Q10 status in plasma and serum resembles more or less a normal bell-shaped curve with 50 percent of adults having below average Coenzyme Q10 status and approximately 16 percent of adults having very low Coenzyme Q10 status.  Only about 16 percent of adults at the top end of the curve can be said to have unusually high Coenzyme Q10 status.

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Coenzyme Q10 and energy for the immune system

woman-sneezing
The immune system protects us against bacterial and viral infections. Coenzyme Q10 is an important bio-nutrient for the optimal functioning of the immune system. It helps to provide energy for the bio-synthesis of immune system cells and energy for the activities of immune system cells.

Energy starvation in the immune system?  Immune system cells starved for energy?  There is a very plausible theory that chronic heart failure is a disease caused by the energy starvation of the heart muscle cells.  Lacking adequate Coenzyme Q10 – an indispensable component of the human cell respiration and oxidative phosphorylation process – the heart muscle cells produce less ATP than is needed to supply the cells with energy. (A concomitant theory holds that Coenzyme Q10, in its reduced form, also protects the heart muscle cells against oxidative damage.)

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Coenzyme Q10 and exercise: what do we know?

exercise-and-coq10
Coenzyme Q10 supplementation performs many roles in the body that benefit athletes and people who exercise. It is an essential co-factor in cellular energy production, it is the most important fat-soluble antioxidant preventing oxidative damage and muscle damage,, and it improves endothelial function.

Does Coenzyme Q10 supplementation improve exercise capacity?  Do we know?  In 2016, Professor Julio J. Ochoa and his colleagues at the University of Granada in Spain conducted an exhaustive review of the published literature about the Coenzyme Q10 supplementation and exercise.  The researchers did database searches and found 372 journal articles about Coenzyme Q10 and exercise.  An amazing number.

Variation in the Coenzyme Q10 and exercise studies
Of course, the results of the studies reported in the 372 journal articles varied quite a bit for a variety of reasons:

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Coenzyme Q10: the best of q10facts.com — part II

emergency-room
Daily supplementation with 200 milligrams of Coenzyme Q10 has been shown to reduce the number of hospitalizations and re-hospitalizations of chronic heart failure patients. The use of Coenzyme Q10 as an adjuvant treatment improves the quality of life for patients and reduces the expenses of health care systems.

Last month, I wrote brief summaries of some of the best articles that have been published on this website.  This month, I want to present summaries of several more good q10facts.com articles about the health benefits of Coenzyme Q10 supplementation.  The information in all of these articles is based on clinical study results published in peer-reviewed bio-medical journals.  In each summary, there is a link to the original article.

Fewer hospitalizations with Coenzyme Q10
In the Q-Symbio study, 420 chronic heart failure patients on conventional heart failure medications were randomly assigned to an adjuvant Coenzyme Q10 treatment group (n=202) or to a placebo control group (n=218).  In the study, Dr. Svend Aage Mortensen and his fellow researchers wanted to test the hypothesis that the condition of the energy-starved heart could be improved by the use of Coenzyme Q10 supplementation.

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Coenzyme Q10: The best of q10facts.com

Karl Folkers
Dr. Karl Folkers, the researcher who established the chemical structure of the Coenzyme Q10 molecule and who developed the biochemical rationale for the use of Coenzyme Q10 as an adjuvant treatment of chronic heart disease, called Coenzyme Q10 the “essential bio-nutrient.”

In this article, I look back over the past 80 q10facts.com articles and pick out my favorites.  Together, these articles give a good picture of what I have tried to present on this website: documented results from scientific studies of the absorption, safety, and efficacy of Coenzyme Q10 supplements in the form of ubiquinone.  At the present time, there simply is not the same quality or quantity of research results related to the use of Coenzyme Q10 supplements in the ubiquinol form.

Coenzyme Q10’s therapeutic value
This article summarized the clinical research evidence for the use of Coenzyme Q10 as an adjunctive therapy for the following patients:

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Coenzyme Q10’s therapeutic value

blister-pack
Human bio-synthesis of Coenzyme Q10 peaks in the early 20s and then declines with increasing age. Supplementation is necessary to provide adequate intakes of the substance for energy production and antioxidant defense. Coenzyme Q10 dissolved in vegetable oils and sealed in gelatin capsules has shown impressive health benefits in randomized controlled trials: Q-Symbio study, KiSel-10 study, and Gulf War Veterans study.

Coenzyme Q10 is a marvelously versatile natural substance.  It is essential for cellular energy production, and it is an important lipid-soluble antioxidant.  Its use as a daily supplement in conjunction with conventional medicines can give heart patients valuable health benefits.

In a 2015 review article, Professor Dr. Roland Stocker of the Medical College, University of New South Wales, in Sydney, Australia, and colleagues evaluated the potential therapeutic value of Coenzyme Q10 supplements:

  • for heart failure patients
  • for patients with high blood pressure
  • for ischemic heart disease patients
  • for cardiac surgery patients
  • for patients taking statin medications

We want to look at the evidence presented in this review article [Ayer 2015].

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Coenzyme Q10: ubiquinone or ubiquinol?

Q10 crystals
Formulation of the Coenzyme Q10 supplements is very important. How do we know which producers of Coenzyme Q10 supplements can take the raw material, pictured here, and dissolve it in lipids and seal it in capsules so that it gives good health effects?

Recently, some readers have written in asking what my problem with the ubiquinol version of Coenzyme Q10 supplements is.  Let me try to answer that question.  I don’t think that I have a problem with ubiquinol itself.  I have great respect for ubiquinol’s utility as a lipid-soluble antioxidant.  The problem that I have tried to address on q10facts.com is the misleading nature of the marketing claims and the stretching of scientific facts in many of the marketing claims for the ubiquinol products.

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The antioxidant function of Coenzyme Q10

woman-leaning-against-the-tree
To live as long in life as we can and stay as young as we can, we need the protection of antioxidants. Coenzyme Q10 is, practically, a human immune system in itself. It quenches harmful free radicals and keeps them from damaging our cells and our DNA.

One theory to explain the process of aging is that there is an accumulation of oxidative damage through the years.  Oxidative damage is the damage to cells and DNA and lipids that occurs as a result of an excess of reactive oxygen species (also called free radicals) beyond the body’s ability to neutralize the harmful free radicals.  The free radical theory of aging presupposes higher free radical production and lower antioxidant protection in older adults.  In accordance with this theory, the use of supplements with antioxidant effects such as Coenzyme Q10, selenium, vitamin C, vitamin E, and various carotenoids and flavonoids is desirable.

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Coenzyme Q10 and older adults and fitness

woman golfing
More physical activity is positively associated with higher plasma levels of Coenzyme Q10 in older adults. CoQ10 is vital for the process of cellular energy production and for antioxidant protection of the cells and plasma lipoproteins.

A 2014 study has shown that greater fitness among older adults is associated with the following health benefits:

  • higher levels of plasma Coenzyme Q10
  • lower levels of lipid peroxidation (degradation of lipids)
  • lower levels of cholesterol

The study participants – 19 men and 24 women – had an average age of 71 years.  The data from the study show that physical activity in the senior years can increase plasma concentrations of Coenzyme Q10 and can reduce the presence in plasma of a well-established bio-marker for oxidative stress [Del Pozo-Cruz 2014].

Coenzyme Q10 and oxidative stress
In the daily course of our using food and oxygen to make energy, we produce dangerous by-products called free radicals.  Exposure to radiation and environmental toxins also produces harmful free radicals in our bodies.

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Coenzyme Q10 and the NQO-1 gene

Cyclist
Coenzyme Q10 is a fat-soluble redox molecule that we produce in nearly all cells in the body. Once we reach our 20’s, our body’s synthesis of Coenzyme Q10 begins to decline with increasing age. But our need for Coenzyme Q10 continues, both in the process of producing ATP energy molecules and in the cells’ defense against harmful free radicals. Consequently, we need a good daily supplement.

NQO1 gene? … NQO-1 enzymes? … I don’t remember reading or hearing about the NQO-1 gene in all of the years that I have been taking Coenzyme Q10 supplements. But, for Dr. William Judy, the NQO-1 gene seems to be one of the three or four Q10 questions that he has been most preoccupied with for several years.

NQO-1 gene important in the biochemistry of Coenzyme Q10
NQO-1 is used as shorthand for both the gene and the oxidoreductase enzymes that the gene codes for.  The NADPH-Quinone Oxidoreductase-1 gene –  to give it its full name –  is the gene that codes in humans for the production of enzymes that reduce quinones to hydroquinones.

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