Individuals with type 2 diabetes are known to have considerably lower plasma/serum Coenzyme Q10 concentrations than do individuals who do not have diabetes [Zhang].
A 2018 meta-analysis and systematic review of the research literature indicates that Coenzyme Q10 supplementation improves glycemic control and increases HDL-cholesterol in individuals with type 2 diabetes [Zhang].
CoQ10 Supplementation and Glycemic Control
The results of the meta-analysis, drawn from an aggregated 13 clinical trials enrolling 795 patients with type 2 diabetes, show that the CoQ10 supplementation significantly decreased HbA1c (p=0.03) and fasting glucose (p=0.005).
Note: HbA1c is a measurement of glycated hemoglobin (hemoglobin bound to glucose). Doctors use HbA1c measurements to get an idea of what a patient’s average blood sugar levels have been over a period of weeks or months. The higher the HbA1c is, the greater the risk of complications related to diabetes.
Coenzyme Q10 Supplementation and Insulin Resistance
In the meta-analysis, the Coenzyme Q10 supplementation did not affect fasting insulin levels or HOMA-IR insulin resistance levels.
Note: Insulin is a hormone that helps to regulate the levels of sugar (glucose) in the blood. HOMA-IR test results show how sensitive or resistant a patient is to the effects of insulin.
The researchers explain that the lack of an effect on fasting insulin and on insulin resistance is an indication that Coenzyme Q10 supplementation is a treatment option that may be safe to use with patients with type 2 diabetes [Zhang]. Patients with type 2 diabetes can use Coenzyme Q10 supplements for their heart health benefits without worrying that the extra Coenzyme Q10 will increase insulin resistance.
CoQ10 Supplementation and Cholesterol Levels
Coenzyme Q10 supplementation was associated, in this meta-analysis, with a The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant.... Read more about this term increase in HDL-C, the so-called good Cholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... Read more about this term. Higher levels of HDL-C are thought to be a good thing [Zhang].
The aggregated data from the 8 studies (out of 13) that addressed the issue of LDL-C, the so-called bad cholesterol, did not show any statistically The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... Read more about this term reduction of LDL-cholesterol through the use of Coenzyme Q10 supplements [Zhang].
Coenzyme Q10 Supplementation and Diabetes Patients taking Statin Medications
Statin medications reduce cholesterol levels and reduce the risk of heart attack. However, in the same period that statin medications have been prescribed, there has also been a significant increase in the risk of heart failure. Professor Okuyama and his colleagues explain that statin medications inhibit not only the body’s synthesis of cholesterol but also its synthesis of Coenzyme Q10. And, if that were not bad enough, the statin medications inhibit the incorporation of Selenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... Read more about this term into the antioxidant selenoproteins, inhibit the synthesis of vitamin K2, and are associated with reduced levels of the enzymatic antioxidants superoxide dismutase and catalase [Okuyama].
Because cholesterol and Coenzyme Q10 are synthesized in the same biochemical pathway, statin medications block the body’s production of Coenzyme Q10. It is practically impossible to make up for the loss of CoQ10 by eating more or eating more wisely. Coenzyme Q10 supplementation is, accordingly, essential for patients with type 2 diabetes who are taking statin medications [Zhang].
Moreover, statin medications themselves are thought to increase the risk of developing type 2 diabetes [Mantle].
Safety of Coenzyme Q10 Supplementation for Patients with Type 2 Diabetes
None of the 13 study publications analyzed in the meta-analysis reported any adverse effects of taking Coenzyme Q10 supplements.
This result alone is not a guarantee of absolute safety, but Coenzyme Q10 generally has been shown to be well-tolerated with no serious adverse effects. There are no known toxic effects associated with Coenzyme Q10. There are no reports of Coenzyme Q10 overdosing in research literature extending back 50 years [Mantle].
Possible Limitations of the Meta-analysis of Coenzyme Q10 and Diabetes Studies
The researchers doing the meta-analysis pointed to the following possible limitations of the analysis [Zhang]:
- The sample sizes in the studies were small.
- The characteristics of the study participants were heterogeneous.
- The duration of the Coenzyme Q10 treatment was relatively short, ranging from 3 to 6 months.
- The effect of longer-term Coenzyme Q10 supplementation on patients with type 2 diabetes has not been tested and documented.
Conclusion: CoQ10 and Type 2 Diabetes Patients
It cannot be emphasized enough that not all Coenzyme Q10 supplements are equally good.
CoQ10 supplements vary in their formulations and, accordingly, in their absorption and bio-availability [Lopez-Lluch].
A cheaper Coenzyme Q10 supplement may possibly have a decent formulation and give a decent bio-availability, but it is surely wisest to stick to CoQ10 supplements with documented absorption and bio-availability and documented significant health effects in clinical studies [Alehagen; Mortensen].
Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., & Dahlström, U. (2013). Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and Coenzyme Q10 supplementation: a 5-year prospective randomized A double-blind study is a study in which neither the investigators nor the study participants know which participants are receiving the active treatment and which participants are receiving the control treatment until the study has been completed and the seal on the code has been broken.... Read more about this term placebo-controlled trial among elderly Swedish citizens. International Journal of Cardiology, 167(5), 1860-1866.
López-Lluch, G., Del Pozo-Cruz, J., Sánchez-Cuesta, A., Cortés-Rodríguez, A. B., & Navas, P. (2019). Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition, 57, 133–140.
Mantle, D. (2017). Coenzyme Q10 supplementation for diabetes and its complications: a review. The British Journal of Diabetes, 17(4): 145-48.
Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., & Littarru, G. P. (2014). The effect of coenzyme Q10 on morbidity and mortality in The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term: results from Q-SYMBIO: a randomized double-blind trial. JACC. The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term, 2(6), 641-649.
Okuyama, H., Langsjoen, P. H., Hamazaki, T., Ogushi, Y., Hama, R., Kobayashi, T., & Uchino, H. (2015). Statins are a class of medications that effectively block the body’s synthesis of cholesterol. In so doing, statins also block the body’s synthesis of Coenzyme Q10.... Read more about this term stimulate Atherosclerosis is the thickening of the artery walls brought about by the build-up of plaque (plaque is made up of cholesterol and other fatty substances and waste products and calcium and fibrin) and the subsequent slowing of the flow of blood through the clogged arteries. More research is needed into the role of Coenzyme Q10 in the prevention and adjunct... Read more about this term and heart failure: pharmacological mechanisms. Expert Review of Clinical Pharmacology, 8(2), 189-199.
Zhang, S.-Y., Yang, K.-L., Zeng, L.-T., Wu, X.-H., & Huang, H.-Y. (2018). Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes is a metabolic disease characterized by high blood sugar levels. Diabetes is caused by the body’s failure to produce sufficient insulin (type 1 diabetes) or by the body’s failure to respond to the available insulin (type 2 diabetes). The high blood sugar levels that are characteristic of diabetes are associated with increased risk of heart attack, stroke, and coronary... Read more about this term: A Systematic Review and Meta-Analysis. International Journal Of Endocrinology, 2018, 6484839.
The information contained in this review article is not intended as medical advice and should not be construed as such.Please click here for additional information about the heart health benefits of Coenzyme Q10 supplementation.