Coenzyme Q10 and Male Infertility

Richard Morrill Fertility July 15, 2021June 18, 2021 0 Comment

There is more and more evidence that Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More plays a physiological role in the maintenance of semen quality [Alahmar 2021]:

Higher CoQ10 concentrations in seminal plasma correlate directly with elevated semen parameters such as sperm motility and sperm count.
Seminal CoQ10 concentrations are sub-optimal in male infertility conditions.

Pregnant woman — Infertility affects an estimated 15% of couples worldwide. Male infertility is a factor in about 50% of cases. The causes of male infertility are poorly understood, but there is evidence that oxidative stress is related to poor seminal fluid quality. Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More is a powerful antioxidantAntioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... More, reducing levels of oxidative stress.

In a 2021 review article, Alahmar et al. [2021] summarize the research into CoQ10’s role in the regulation of male reproductive function:

restores semen parameters in male infertility patients
reduces the blood levels of biomarkers for oxidative stress
improves pregnancy and assisted reproductive technology outcomes
reduces sperm DNA fragmentation

CoQ10 Effects on Sperm Parameters

Alahmar et al. [2021] have reviewed several clinical trials of the CoQ10 supplementation of patients with male infertility. Overall, the outcomes of these studies show the following beneficial effects:

increased concentrations of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More in the semen and in spermatozoa
enhanced sperm parameters: sperm concentration, motility, and morphology
improved oxidative stress bio-markers and increased protection against free radical-induced sperm damage

CoQ10 Effects on Sperm DNA Fragmentation

Current evidence shows that Sperm DNA Fragmentation plays a crucial role in male infertility. Oxidative stress may be the key mechanism causing the sperm DNA fragmentation. An excess of harmful free radicalsFree radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... More may be causing kinks and breaks in sperm DNA.

Coenzyme Q10 and Female Infertility: Two Meta-Analyses

Richard Morrill Fertility May 30, 2021May 29, 2021 0 Comment

Compared with placebo or no-treatment, oral supplementation with Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More can increase clinical pregnancy rates in women undergoing Assisted Reproductive Technology procedures [Florou 2020].

Compared to control study participants, women diagnosed with poor ovarian response undergoing controlled ovarian stimulation have better clinical outcomes in terms of pregnancy achievement and in terms of a lower dosage of gonadotrophin required for ovulation induction when Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More is used as an adjuvant therapy [Zhang 2020].

CoQ10 Supplementation to Improve Fertility in Women

Richard Morrill Fertility September 15, 2020September 16, 2020 0 Comment

Storch bringing baby — Three meta-analyses show beneficial effects of CoQ10 supplementation on semen quality, semen quantity, and semen mobility. Here, a meta-analysis of studies of CoQ10 supplementation of women with infertility shows a significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... More effect on clinical pregnancy rates.

A meta-analysis of five randomized controlled clinical studies (n=449 infertile women) has shown that CoQ10 supplementation increases clinical pregnancy rates compared with placebo treatment or no treatment. The CoQ10 supplementation significantly increases clinical pregnancy rates both overall and in infertility subgroups such as the poor ovarian response subgroup (n=286) and the polycystic ovarian syndrome subgroup (n=163) [Florou 2020].

All study participants were women of reproductive age (mean age 33 years) diagnosed with either poor ovarian response or polycystic ovary syndrome. All were attending an assisted reproductive technology clinic [Florou 2020].

CoQ10 for Women with Poor Ovarian Response

Richard Morrill Fertility August 15, 2020September 16, 2020 0 Comment

The CoQ10 pre-treatment was associated with improved pregnancy and live birth rates.

After one completed assisted reproductive technique treatment cycle, the women treated with Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More had a 32% pregnancy rate and a 29% live birth rate. The women in the control group had a pregnancy rate of 17% and a 16% live birth rate.

Coenzyme Q10 and Male Infertility

Richard Morrill Fertility April 3, 2019February 10, 2020 0 Comment

Data from randomized controlled trialsRandomized controlled trials are studies in which patients or healthy volunteers are assigned at random (purely by chance) to receive one or more clinical interventions. One or more of the interventions is the active treatment being tested. Another of the interventions is the control against which the active treatment is being tested. The control is, typically, the standard practice or... More show that Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplementation is positively associated with improved sperm density and motility and, to a certain extent, with improved pregnancy rates.

Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplementation results in significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... More improvement in various sperm parameters: sperm density, sperm motility, and sperm morphology and, quite possibly, in pregnancy rates [Safarinejad].

Actually, we have known about the benefits of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More for treating men with significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... More abnormalities in sperm morphology and motility for 10 – 15 years now. Let’s have a look at the clinical research results reported in journal articles indexed by Medline.

CoQ10 and Male Infertility Associated with Abnormal Sperm Parameters

Safarinejad, M. R. (2009). Efficacy of Coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. The Journal Of Urology, 182(1), 237–248.

Researchers enrolled 212 infertile men with various sperm abnormalities. Half of the patients were randomly assigned to receive 300 milligrams of Coenzyme Q10 daily, and half took matching placebos for 26 weeks. The researchers then continued to follow the patients’ progress for a 30-week treatment-free phase.

Coenzyme Q10 and pregnancy

Richard Morrill Fertility, Healthy People January 1, 2017January 2, 2017 2 Comments

male-infertility-picture — Pregnancy depends upon the sperm’s reaching the egg. Daily supplementation with Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More capsules is associated with significantly improved sperm density, sperm movement, and normal sperm shape as well as with improved pregnancy rates.

What about infertility problems and Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More, I was asked the other day. Mightn’t the improvement of cellular energy production and the protection against oxidative stress that Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplements give, mightn’t they also help sperm quality and sperm motility? What about Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More help for the quality of female egg cells?

Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More and male infertility
Nature Reviews: Urology
In 2011, Dr. Annette Fenner, chief editor at Nature Reviews: Urology, published a note to the effect that supplementation with Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More improves semen quality parameters and that the improvement in the sperm has been seen to be associated with improved pregnancy rates and live birth rates [Fenner].