Q. Good morning, Dr. Judy. Thank you for taking some time for q10facts.com. Last time we talked about the safety of Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term. What about the absorption and bioavailability of Coenzyme Q10? That has been a special area of research for you at the SIBR Research Institute, I think.
A. Good morning. Yes, you are correct. I have been involved in several clinical studies of the efficacy of Coenzyme Q10 supplementation, but my big interest for the past 20 years has been in testing the absorption and bioavailability of the various Coenzyme Q10 supplements. Maybe I should start by distinguishing between absorption studies and bioavailability studies.
I understand absorption studies to be studies of the movement of the Coenzyme Q10 molecules from the small intestines through the absorption cells and into the body’s lymph system. Coenzyme Q10 absorption studies measure the concentration or the amount of Coenzyme Q10 in the blood after the study participants have taken a single dose of Coenzyme Q10, typically a 100-milligram dose.
Coenzyme Q10 bioavailability studies, on the other hand, are studies of the accumulation of the absorbed Coenzyme Q10 in the blood during an extended interval of Coenzyme Q10 supplementation, for example, over a 30-day period. Bioavailability studies measure the steady-state blood levels of Coenzyme Q10 that are available to the body cells. Obviously, good bioavailability depends upon good absorption.
I mention this at the outset because in the literature, I sometimes see the two terms used interchangeably, and that is not correct, in my view.
Q. Thank you. What are the factors affecting the absorption of Coenzyme Q10 from a 100-milligram capsule, would you say?
A. Absorption of Coenzyme Q10 is a difficult process in the best of times. The Coenzyme Q10 raw material comes in the form of a crystalline powder. There are millions of Coenzyme Q10 molecules in a single crystal.
The human body cannot absorb crystals. So, the supplement manufacturer needs to find a way to dissociate the Coenzyme Q10 crystals into single molecules and keep them dissolved in vegetable oils in soft-gel capsules.
This is not easily done, but it is necessary. Coenzyme Q10 crystals will not completely dissociate by themselves inside the stomach or the small intestine before they reach the absorption cells in the small intestine for one very good reason. The melting point of Coenzyme Q10 crystals is ten degrees centigrade above the normal body temperature.
Further complicating the absorption of Coenzyme Q10 from supplements is the fact that the Coenzyme Q10 molecules are large molecules, and they are fat-soluble molecules with a polar head and a non-polar tail. So, these fat-soluble Coenzyme Q10 molecules need to get through the watery phase in the small intestine to reach the absorption cells.
The Coenzyme Q10 molecules are converted to micelles by the bile salts in the duodenum. They then diffuse into the watery space adjacent to the absorption cells. To pass through the absorption cells, they have a lipid carrier (monoglyceride) to facilitate their passage through the small intestine to the absorption cells.
Tricky business. You can see why the formulation of the Coenzyme Q10 supplement is decisive for the absorption. And you can see why less expensive supplements probably have not had enough care put into their formulation. Crystal free formulations are not easy to achieve.
Q. Whew. Got it. Not all Coenzyme Q10 supplements will be absorbed equally well. The formulation of the supplement is the important thing. What about the issue of the form of the Coenzyme Q10? The debate about Ubiquinone, the oxidized form of Coenzyme Q10, expressed as Q10 or CoQ10, is absolutely essential for the mitochondrial ATP energy production process. Ubiquinone is the form of Coenzyme Q10 that the body synthesizes, and ubiquinone is the form of Coenzyme Q10 that has been extensively tested for safety, absorption, and efficacy in clinical trials.... Read more about this term and ubiquinol? What can you tell us about that?
A. Okay, let’s start by saying that Coenzyme Q10 molecules are redox molecules. In the body, they convert back and forth between their oxidized form – called ubiquinone – and their reduced form – called ubiquinol. The ubiquinone form is the form that the body itself synthesizes, and the ubiquinone form is the form that is essential for the process of cellular ATP (adenosine triphosphate) molecules are the high-energy molecules with easily broken phosphate bonds that release energy to the energy-requiring processes in the cells. Coenzyme Q10 is essential to the process of ATP production.... Read more about this term energy production.
The ubiquinone form is also the form that has been tested in numerous clinical trials dating back to the 1980s and continuing up to the present day with the publication of the results of the Q-Symbio study and the KiSel-10 study.
Ubiquinol is the form of Coenzyme Q10 that acts as a fat-soluble Antioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term protecting cells and proteins and DNA against the harmful effects of Free radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... Read more about this term and super-oxides. Ubiquinol has been available as a supplement for only about ten years, and it has not been extensively tested in clinical trials in the way that ubiquinone has.
Q. What are the reasons for taking ubiquinol supplements instead of ubiquinone Coenzyme Q10 supplements?
A. I don’t know of any good reasons. Studies that I have done and that I have seen done show that ubiquinol supplements do not give a better absorption than the best ubiquinone Coenzyme Q10 supplements do.
Furthermore, I have seen evidence that the ubiquinol in supplements can become oxidized – give up electrons – and convert to ubiquinone already in the soft-gel capsule in which case why pay for ubiquinol?
And I have seen evidence that the ubiquinol in supplements is converted, in the stomach and in the small intestine, to the ubiquinone form before it reaches the absorption cells. So, again, I wonder, what is the point of spending good money on relatively untested and undocumented ubiquinol supplements?
Q. But aren’t there claims on the Web for better absorption of ubiquinol?
A. Yes, but those claims look strange to me. The claims are based on the mis-matching of results from separate studies that were done at least 10 years apart. The claims are not based on head-to-head comparisons.
Everything is different in the studies that are compared. The study participants are different. The researchers are different. The dosages are different. The study methodologies are different. I don’t think that the claims for ubiquinol that are out there are based on good science.
Meanwhile, we have some well-designed clinical trials showing significant heart health benefits from taking ubiquinone Coenzyme Q10 supplements. I have already mentioned the Q-Symbio study and the KiSel-10 study. I know you have written about the results of these studies on q10facts.com.
Q. Another issue is the claim that anyone over 40 years of age should supplement with ubiquinol.
A. Yes, I’m aware of this claim, but it is not supported by clinical studies. For example, it has been reported that only 4 % of the Caucasian population have reduced plasma ubiquinol by the age of 40. In the Indian, Chinese, and Mexican populations that have been studied, about 20 to 24 % have a reduction of plasma ubiquinol by 40. This reduction has been shown to be due to a mutation of the NQO-1 gene that controls the synthesis of the oxi-reductase enzyme that converts ubiquinone to ubiquinol. These data do not support the claim that everyone should supplement with ubiquinol by the age of 40.
Q. Thank you for talking with us about Coenzyme Q10 absorption, Dr. Judy. To get good health benefits, we need good absorption of the Coenzyme Q10. You probably know, the motivation for starting q10facts.com came when I got excited by the results of Dr. Alehagen’s KiSel-10 study and Dr. Mortensen’s Q-Symbio study. I wanted to share that information with as many people as I could.
A. I understand that. Coenzyme Q10 is such an essential supplement. Again, it is surprising that it is so relatively little known in the United States.
Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., & Dahlström, U. (2013). Cardiovascular mortality and N-terminal-proBNP reduced after combined Selenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... Read more about this term and coenzyme Q10 supplementation: a 5-year prospective randomized A double-blind study is a study in which neither the investigators nor the study participants know which participants are receiving the active treatment and which participants are receiving the control treatment until the study has been completed and the seal on the code has been broken.... Read more about this term placebo-controlled trial among elderly Swedish citizens. International Journal of Cardiology, 167(5), 1860-1866.
Judy, W. V., Stogsdill, W. W., & Folkers, K. (1993). Myocardial preservation by therapy with Coenzyme Q10 during heart surgery. The Clinical Investigator, 71(8 Suppl), S155-S161.
Judy, W. V., Stogsdill, W. W., Judy, D. S., & Judy, J. S. (2007). Coenzyme Q10: Facts or Fabrications? Natural Products Insider. Retrieved from http://www.zmc-usa.com/docs/CoQ10_Facts_or_Fabrications.pdf.
Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., & Littarru, G. P. (2014). The effect of coenzyme Q10 on morbidity and mortality in The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term: results from Q-SYMBIO: a randomized double-blind trial. JACC. The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term, 2(6), 641-649.
Disclaimer: The information presented in this interview is not intended as medical advice and should not be construed as such.Please click here for additional information about the heart health benefits of Coenzyme Q10 supplements.