Oxygen is a strange element in our lives. We cannot live without it. We use it to burn nutrients to generate ATP (adenosine triphosphate) molecules are the high-energy molecules with easily broken phosphate bonds that release energy to the energy-requiring processes in the cells. Coenzyme Q10 is essential to the process of ATP production.... Read more about this term energy in the cells. So far, so good.
But, in the process of producing energy from nutrients – the process is called Cellular respiration is the technical term for the metabolic reactions and processes in the cells that convert the biochemical energy from nutrients into adenosine triphosphate (ATP) energy and then release waste products.... Read more about this term – some small portion of the oxygen produces a by-product: Free radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... Read more about this term. These radicals are atoms or molecules with one or more unpaired electrons in the outer orbit. There are many types of radicals; the radicals derived from oxygen – known as The free radicals of most concern in the bio-medical field are the free radicals derived from oxygen, they are called reactive oxygen species. Specifically, there are the superoxide anions, the peroxides including hydrogen peroxide, and the hydroxyl radicals. Free radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals play both... Read more about this term – are some of the most toxic radicals.
In moderate quantities, these free radicals have some useful inter-cellular and intra-cellular signaling functions. Moreover, the immune system’s phagocytic cells use radicals to kill pathogens. However, in large quantities, the highly reactive radicals that escape the See Cellular respiration of the The mitochondria are the bean-shaped organelles in the cells. They are the key organelles with responsibility for the production of ATP energy molecules.... Read more about this term can be toxic to the cells. They can damage DNA, RNA, proteins and fatty acids in the blood and tissue.
In fact, the definition of oxidative stress is an imbalance between the quantities of potentially harmful free radicals and the quantities of antioxidants available to neutralize the free radicals before they can set off damaging chain reactions. The process of Oxidation is the chemical reaction of a substance with oxygen. Peroxidation is the extreme form of oxidation that results from free radicals’ stealing electrons from lipids, either in the cell membranes or in the lipoproteins. The final product of lipid peroxidation is highly reactive malondialdehyde, a bio-marker for oxidative stress and damage.... Read more about this term is one of the most common examples of toxic activity by oxygen-derived radicals; the radicals target the fatty acids in the phospholipid cellular membranes, i.e. the plasma membranes of the cells and the mitochondrial membranes. The Antioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term enzymes are important for the prevention of lipid Oxidation is the chemical reaction of a substance with oxygen. Peroxidation is the extreme form of oxidation that results from free radicals’ stealing electrons from lipids, either in the cell membranes or in the lipoproteins. The final product of lipid peroxidation is highly reactive malondialdehyde, a bio-marker for oxidative stress and damage.... Read more about this term.
Coenzyme Q10 has an antioxidant role
In its reduced form, Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term, both the Coenzyme Q10 that the body synthesizes and the Coenzyme Q10 that we ingest from supplements, is an important fat-soluble antioxidant.
Let me explain that: Coenzyme Q10 molecules are redox molecules. The oxidized form of Coenzyme Q10 is called Ubiquinone, the oxidized form of Coenzyme Q10, expressed as Q10 or CoQ10, is absolutely essential for the mitochondrial ATP energy production process. Ubiquinone is the form of Coenzyme Q10 that the body synthesizes, and ubiquinone is the form of Coenzyme Q10 that has been extensively tested for safety, absorption, and efficacy in clinical trials.... Read more about this term. It is the form that can accept (gain) electrons from other molecules. The reduced form of Coenzyme Q10 is called ubiquinol. It is the form that can donate (lose) electrons to free radical molecules that are thus neutralized by gaining the one or two electrons.
The redox pair – ubiquinone and ubiquinol – convert back and forward multiple times in the body. But I want to save Coenzyme Q10’s antioxidant role for another day. Today, I want to discuss Coenzyme Q10’s role in strengthening the activity of enzymatic antioxidants.
Coenzyme Q10’s role in antioxidant defense
Two questions come to mind when we talk about Coenzyme Q10 and free radicals and antioxidants.
- What are some of the most important antioxidant enzymes that protect our DNA and our cells?
- How does Coenzyme Q10 supplementation affect the activity of these important antioxidant enzymes?
Crucial antioxidant enzymes
Superoxide radicals are a by-product of the cells’ metabolism of oxygen. Left unchecked, the superoxides can be very harmful to cells and DNA. The superoxide dismutase enzymes – found in the cytoplasm, in the mitochondria, and outside the cells – are crucial antioxidants that catalyze the disarming of the superoxide radicals. Superoxide dismutase enzymes catalyze the decomposition of superoxide radicals to hydrogen peroxide and oxygen.
Catalase enzymes are very important enzymes for the protection of the cells from oxidative damage. Catalase enzymes catalyze the breaking down of hydrogen peroxide molecules to water and oxygen. In this way, the catalase enzymes complete the detoxification of the superoxide radicals that was started by the superoxide dismutase enzymes.
Glutathione peroxidase enzymes belong to a group of enzymes that contain Selenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... Read more about this term as an important component. Like catalase, the glutathione peroxidase enzymes also catalyze the breaking down of hydrogen peroxide. Furthermore, the glutathione peroxide enzymes reduce organic peroxide radicals to alcohols, thus eliminating toxic free radicals.
Quick summary of oxygen-derived radicals and antioxidants
- Superoxide dismutase breaks down superoxide radicals to hydrogen peroxide and water.
- Catalase and glutathione peroxidase break down hydrogen peroxide to water and oxygen.
- These processes are important because the hydrogen peroxide can be converted to highly damaging hydroxyl radicals that can and will damage DNA, lipids, and proteins.
Effect of Coenzyme Q10 supplementation on antioxidant enzymes
Dr. Liu and a team of researchers  have shown that daily supplementation of liver cancer patients after surgery with 300 milligrams of Coenzyme Q10 is significantly negatively associated with markers of oxidative stress and significantly positively associated with the antioxidant enzyme activity of superoxide dismutase, catalase, and glutathione peroxidase.
Dr. Nadjarzadeh and colleagues  have shown that 200 milligrams of Coenzyme Q10 daily is associated with improved superoxide dismutase and catalase enzyme activity and with improved semen parameters in infertile men patients.
Dr. Sanoobar and colleagues  have shown that daily supplementation with 500 milligrams of Coenzyme Q10 is associated with significantly increased superoxide dismutase activity and with decreased oxidative stress in patients with relapsing-remitting multiple sclerosis.
Dr. Lee and colleagues  have shown that the activity levels of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase were significantly higher and the levels of inflammatory marker were significantly lower following daily Coenzyme Q10 supplementation of coronary artery disease patients on statin medications. The supplementation level was 300 milligrams daily.
Dr. Lee and a team of researchers  have shown that daily supplementation with 150 milligrams of Coenzyme Q10 is associated with significant increases in the activity of the antioxidant enzymes superoxide dismutase and catalase and with decreased oxidative stress in coronary artery disease patients.
Dr. Tiano and colleagues in a research group led by Professor Gain Paolo Littarru  have shown that daily supplementation with 100 milligrams of Coenzyme Q10 improves superoxide dismutase activity and improves endothelium-dependent blood vessel dilation in patients with coronary artery disease.
Dr. Kalpravidh and colleagues  have shown that daily supplementation of thalassemia patients with 100 milligrams of Coenzyme Q10 as an adjunct therapy significantly increased the activity of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, decreased levels of oxidative stress, and improved the patients’ quality of life.
The three groups of antioxidant enzymes – superoxide dismutase, catalase, and glutathione peroxidase – are important for protecting the cells against oxidative damage. Cumulative oxidative damage may be linked to the development of degenerative diseases and to ageing.
The results of the randomized controlled studies summarized above show that Coenzyme Q10 supplementation is significantly associated with improved antioxidant enzyme activity and with decreased oxidative stress markers.
In addition to the enzymatic antioxidants, there are other non-enzymatic antioxidants that are important and that have a relationship with Coenzyme Q10:
- Vitamin C
- Vitamin E is a fat-soluble vitamin that plays an important role as an antioxidant in the body. Vitamin E neutralizes harmful free radicals. Coenzyme Q10 regenerates Vitamin E after the vitamin E has neutralized free radicals.... Read more about this term
- Glutathione (not to be confused with glutathione peroxidase)
Moreover, there are various flavonoids and carotenoids that can act as antioxidants. I will want to write about Coenzyme Q10 and non-enzymatic antioxidants in a separate article.
Selenium in the glutathione peroxidase and the thioredoxin reductase enzymes also deserves more attention that I have given it in this article. Think, for example, of the beneficial health effects of supplementation with a combination of selenium and Coenzyme Q10 in the KiSel-10 study [Alehagen].
Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., & Dahlström, U. (2013). Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized A double-blind study is a study in which neither the investigators nor the study participants know which participants are receiving the active treatment and which participants are receiving the control treatment until the study has been completed and the seal on the code has been broken.... Read more about this term placebo-controlled trial among elderly Swedish citizens. International Journal of Cardiology, 167(5), 1860-1866.
Kalpravidh, R. W., Wichit, A., Siritanaratkul, N., & Fucharoen, S. (2005). Effect of coenzyme Q10 as an antioxidant in beta-thalassemia/Hb E patients. Biofactors (Oxford, England), 25(1-4), 225-234.
Lee, B., Tseng, Y., Yen, C., & Lin, P. (2013). Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during Statins are a class of medications that effectively block the body’s synthesis of cholesterol. In so doing, statins also block the body’s synthesis of Coenzyme Q10.... Read more about this term therapy: a randomized, placebo-controlled trial. Nutrition Journal, 12(1), 142. doi:10.1186/1475-2891-12-142
Lee, B., Huang, Y., Chen, S., & Lin, P. (2012). Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition (Burbank, Los Angeles County, Calif.), 28(3), 250-255. doi:10.1016/j.nut.2011.06.004
Liu, H., Huang, Y., Cheng, S., Huang, Y., & Lin, P. (2016). Effects of coenzyme Q10 supplementation on antioxidant capacity and Inflammation is an immune system response to an injury to cells or tissues. It is the body’s attempt to defend against invaders such as bacteria andviruses and to mend the damage done by invaders. Typically, inflammation manifests itself in the form of fever and swelling, in the swarming of white blood cells and the release of cytokines to fight against... Read more about this term in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. Nutrition Journal, 15(1), 85.
Nadjarzadeh, A., Shidfar, F., Amirjannati, N., Vafa, M. R., Motevalian, S. A., Gohari, M. R., & … Sadeghi, M. R. (2014). Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised Clinical trials are research studies in which various treatments, interventions, or tests are investigated for their safety and efficacy when used to detect, prevent, or treat diseases and medical conditions in patients and healthy volunteers. The gold standard for clinical trials are randomized, double-blind, placebo-controlled studies.... Read more about this term. Andrologia, 46(2), 177-183. doi:10.1111/and.12062
Sanoobar, M., Eghtesadi, S., Azimi, A., Khalili, M., Jazayeri, S., & Reza Gohari, M. (2013). Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. The International Journal of Neuroscience, 123(11), 776-782. doi:10.3109/00207454.2013.801844
Tiano, L., Belardinelli, R., Carnevali, P., Principi, F., Seddaiu, G., & Littarru, G. P. (2007). Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. European Heart Journal, 28(18), 2249-2255.
The information presented in this review article is not intended as medical advice and should not be construed as such.Please click here for additional information about the heart health benefits of Coenzyme Q10 supplementation.