How does Coenzyme Q10 supplementation keep the heart young and healthy? The primary explanation is that Coenzyme Q10 is absolutely vital to the cellular process of producing energy, and the heart muscle needs energy constantly. An energy-starved heart is a failing heart.
A second and also important explanation is that oxidative damage causes the heart muscle cells to age and deteriorate. Coenzyme Q10 has Antioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term and anti-inflammatory effects that can help to prevent the development of Atherosclerosis is the thickening of the artery walls brought about by the build-up of plaque (plaque is made up of cholesterol and other fatty substances and waste products and calcium and fibrin) and the subsequent slowing of the flow of blood through the clogged arteries. More research is needed into the role of Coenzyme Q10 in the prevention and adjunct... Read more about this term.
Thirdly, Coenzyme Q10 has a moderate but The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... Read more about this term blood pressure lowering effect [Digiesi].
Oxidative damage: structural damage to cell components such as proteins, lipids, and DNA that is caused by chain reactions set off by harmful Free radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... Read more about this term. The chain reactions can be terminated by antioxidants such as Coenzyme Q10.
Atherosclerosis: thickening of the artery walls brought about by the build-up of plaque (plaque is made up of Cholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... Read more about this term and other fatty substances and waste products and calcium and fibrin).
When do we need Coenzyme Q10?
We, all of us, need a daily Coenzyme Q10 supplement once we get into our 30’s and 40’s and beyond because as we (adults) get older, our bodies produce less Coenzyme Q10. We especially need Coenzyme Q10 for any of the following conditions:
- if we take a statin medication because statin medications inhibit our bodies’ own production of Coenzyme Q10
- if we want to prevent the development or worsening of heart disease, low energy syndrome disorders, or high blood pressure
- if we are scheduled for any sort of heart surgery
The The endothelium is the layer of cells that line the surface of the inside of the arteries and veins, the heart, and lymph vessels.The endothelium releases molecules, e.g. nitric oxide, angiotensin II, etc., that help to expand (dilate) or contract (constrict) the blood vessels and thus raise or lower blood pressure. The cells of the endothelium release substances (called factors)... Read more about this term and Coenzyme Q10 supplementation
First off, what is the endothelium?
The endothelium is the bio-medical term for the layer of cells that line the surface of the inside of the arteries and veins, the heart, and lymph vessels.
Secondly, what does the endothelium do?
The endothelium releases molecules, e.g. nitric oxide, angiotensin II, etc., that help to expand (dilate) or contract (constrict) the blood vessels and thus raise or lower blood pressure. The cells of the endothelium release substances (called factors) that help to maintain heart and blood vessel wall tone and that help to inhibit platelet aggregation and Inflammation is an immune system response to an injury to cells or tissues. It is the body’s attempt to defend against invaders such as bacteria andviruses and to mend the damage done by invaders. Typically, inflammation manifests itself in the form of fever and swelling, in the swarming of white blood cells and the release of cytokines to fight against... Read more about this term [Littarru].
Two studies of Coenzyme Q10 supplementation have shown improved endothelial function in the brachial artery, the major artery in the upper arm. In the one study, the patients were type-2 diabetes patients [Watts]; in the second study, the patients were type-2 diabetes patients who were also being treated with statin medications [Hamilton].
The researchers suggested that the Coenzyme Q10 improvement of endothelial function might involve two mechanisms:
- reduced extent of oxidative damage
- increased endothelial release of nitric oxide because of an improvement in vascular oxidative stress [Watts]
Thirdly, what happens in cases of Endothelial dysfunction may be thought of as the failure of the cells lining the inside of arteries and veins to regulate properly blood vessel relaxation and contraction, blood clotting, immune function, and platelet adhesion. Endothelial dysfunction prevents the blood vessels from dilating sufficiently and can lead to increased risk of atherosclerosis, heart attack, and stroke. Coenzyme Q10 supplementation is associated... Read more about this term?
Endothelial dysfunction involves imbalances in the endothelial cells’ releasing of factors that dilate or constrict the blood vessels. The stable equilibrium (homeostasis) of the blood vessels is lost.
Endothelial dysfunction is a predictor of heart disease
Endothelial dysfunction is an early sign of disorders of the blood vessels that are commonly seen in pre-diabetic individuals; furthermore, endothelial dysfunction is an independent predictor of heart disease [Littarru].
Causes of endothelial dysfunction
Many causes play into the development of endothelial dysfunction in pre-diabetic and type-2 diabetic patients. The following conditions are prominent causes of endothelial dysfunction:
- insulin resistance
- abnormal amounts of lipids in the blood
- high blood pressure
- high blood sugar levels
All of these conditions can induce the oxidative stress that leads to the development of endothelial dysfunction [Littarru].
Coenzyme Q10 improves endothelial function
The use of antioxidant supplements can help to prevent the development of endothelial dysfunction. Antioxidants such as Coenzyme Q10 can and do improve endothelial function in pre-diabetic and diabetes patients. However, complete reversal of endothelial dysfunction is not likely, given the complex nature of the condition.
Combination supplements containing Coenzyme Q10
A promising antioxidant approach to the prevention and/or amelioration of endothelial dysfunction involves the use of Coenzyme Q10 supplements together with fish oil supplements and l-arginine supplements [Littarru].
In the KiSel-10 study, a daily combination of Coenzyme Q10 capsules and high selenium yeast tablets administered to healthy elderly study participants over a four-year period significantly reduced the risk of death because of heart disease [Alehagen].
Adjuvant treatment with Coenzyme Q10 supplements is especially important in patients diagnosed with chronic heart failure, Ischemic heart disease is heart disease caused by reduced blood flow to the heart. Ischemic heart disease is, in most cases, coronary artery disease. Blockage of the coronary arteries reduces the flow of blood and oxygen to the heart.... Read more about this term, atherosclerosis, high blood pressure, and diabetes.
Caution to patients taking statin medications
All patients taking a statin medication should discuss Coenzyme Q10 supplementation with a cardiologist because the bio-medical literature clearly shows that statin medications inhibit the body’s production of Coenzyme Q10. Okuyama and Langsjoen have suggested pharmacological mechanisms by which statin medications may aggravate The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term and atherosclerosis [Okuyama].
Coenzyme Q10 supplementation improves the functioning of the heart muscle cells and the arteries and veins by improving mitochondrial function and by acting as a lipid-soluble antioxidant. The beneficial health effects of Coenzyme Q10 may be of heightened importance to pre-diabetic and diabetes patients who are at risk of endothelial dysfunction as well as of importance to anyone at risk of impaired blood vessel function.
Exercise therapy together with Coenzyme Q10 supplementation has been shown to amplify the positive effects of the Coenzyme Q10 supplementation on the ability of the heart to contract and pump blood [Belardinelli].
The high levels of plasma Coenzyme Q10 achieved by supplementation are not associated with any side effects [Belardinelli].
Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., & Dahlström, U. (2013). Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized A double-blind study is a study in which neither the investigators nor the study participants know which participants are receiving the active treatment and which participants are receiving the control treatment until the study has been completed and the seal on the code has been broken.... Read more about this term placebo-controlled trial among elderly Swedish citizens. International Journal of Cardiology, 167(5), 1860-1866.
Belardinelli, R., Muçaj, A., Lacalaprice, F., Solenghi, M., Seddaiu, G., Principi, F., & Littarru, G. P. (2006). Coenzyme Q10 and exercise training in The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term. European Heart Journal, 27(22), 2675-2681.
Digiesi, V., Cantini, F., Oradei, A., Bisi, G., Guarino, G. C., Brocchi, A., & Littarru, G. P. (1994). Coenzyme Q10 in essential Hypertension is abnormally high blood pressure, usually defined as adult systolic blood pressure above 140 mm Hg or adult diastolic blood pressure above 90 mm Hg. Systolic blood pressure is blood pressure measured during the contracting (pumping) of the left ventricle of the heart. Diastolic blood pressure is blood pressure measured during the relaxation of the left ventricle. A meta-analysis... Read more about this term. Molecular Aspects of Medicine, 15 Suppls257-s263.
Hamilton, S. J., Chew, G. T., & Watts, G. F. (2009). Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care, 32(5), 810-812.
Littarru, G. P., Tiano, L., Belardinelli, R., & Watts, G. F. (2011). Coenzyme Q10, endothelial function, and cardiovascular disease. Biofactors (Oxford, England), 37(5), 366-373.
Okuyama, H., Langsjoen, P. H., Hamazaki, T., Ogushi, Y., Hama, R., Kobayashi, T., & Uchino, H. (2015). Statins are a class of medications that effectively block the body’s synthesis of cholesterol. In so doing, statins also block the body’s synthesis of Coenzyme Q10.... Read more about this term stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Review of Clinical Pharmacology, 8(2), 189-199.
Watts, G. F., Playford, D. A., Croft, K. D., Ward, N. C., Mori, T. A., & Burke, V. (2002). Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type II Diabetes is a metabolic disease characterized by high blood sugar levels. Diabetes is caused by the body’s failure to produce sufficient insulin (type 1 diabetes) or by the body’s failure to respond to the available insulin (type 2 diabetes). The high blood sugar levels that are characteristic of diabetes are associated with increased risk of heart attack, stroke, and coronary... Read more about this term. Diabetologia, 45(3), 420-426.Please click here for more information about Coenzyme Q10 and good heart health.