Coenzyme Q10 Protects Against Oxidative Stress and Inflammation

Herewith summaries of 2020-2021 meta-analyses of randomized controlled trials of Coenzyme Q10 supplementation for protection against oxidative stress and chronic inflammation. Note: A meta-analysis is a specific procedure for the pooling and evaluating of data from many individual studies for the purpose of getting more precise results.

CoQ10 and Protection Against Oxidative Stress

Hajiluian et al. investigated the antioxidant effect of CoQ10 supplementation in an analysis of 17 randomized controlled trials enrolling 972 participants. The aggregated data showed that CoQ10 supplementation is associated significantly with increased serum total antioxidant capacity, with increased superoxide dismutase levels, and with decreased malondialdehyde levels compared to the placebo group. The researchers concluded that CoQ10 supplementation improves antioxidant protection against oxidative damage caused by reactive oxygen species.

Akbari et al. investigated the antioxidant effects of CoQ10 supplementation in an analysis of 17randomized clinical trials enrolling 963 participants. They found that CoQ10 supplementation was associated significantly with a decrease in malondialdehyde levels and with increases in total antioxidant capacity and superoxide dismutase activity.

Sangsefidi et al. investigated the antioxidant effect of CoQ10 supplementation in an analysis of 21 randomized controlled trials enrolling 1,170 participants (614 participants in the intervention groups and 556 in the placebo groups). They found that the CoQ10 supplementation significantly increased the levels of total antioxidant capacity, glutathione peroxidase, superoxide dismutase, and catalase and significantly reduced the levels of malondialdehyde.

Definitions

  • Total antioxidant capacity: various spectrophotometric methods are used to evaluate the antioxidant response against the free radicals.
  • Superoxide dismutase: an antioxidant enzyme that catalyzes the breakdown of harmful oxygen molecules in cells.
  • Glutathione peroxidase: the name of a family of selenium containing selenoproteins that protect against oxidative damage.
  • Catalase: an antioxidant enzyme that catalyzes the reduction of the radical hydrogen peroxide.
  • Malondialdehyde: a highly reactive by-product of lipid peroxidation and a bio-marker for oxidative stress.

CoenzymeQ10 and Protection Against Systemic Inflammation

Dludla et al. [2020, May] investigated the effect of CoQ10 supplementation on systemic inflammation in six randomized controlled trials enrolling 318 participants. The analysis of the pooled data showed that CoQ10 supplementation significantly lowered bio-markers of inflammation in individuals with metabolic syndrome as compared to individuals with metabolic syndrome on placebo.

  • metabolic syndrome: the medical term for a combination of diabetes, high blood pressure, and obesity, which increases the risk of coronary heart disease, stroke, and other disorders involving the blood vessels.

Coenzyme Q10 and Protection in Diabetic and Metabolic Syndrome Patients

Dludla et al. [2020, March] also investigated the effect of CoQ10 supplementation in patients diagnosed with diabetes or metabolic syndrome in 12 randomized controlled studies enrolling 650 patients. They found that the CoQ10 supplementation significantly reduced cardiovascular disease-risk-related indexes such as total cholesterol and low-density lipoprotein levels in diabetic patients as compared to diabetic patients on placebo.

Talking Points About Coenzyme Q10 Supplements

  1. Not all CoQ10 supplements are equally well made and equally well absorbed and effective. It is important to choose a well-documented CoQ10 supplement. Otherwise, the money spent on the supplement may be wasted. The cheaper the supplement is, the more likely this is true.
  2. A well-formulated ubiquinone Coenzyme Q10 supplement will significantly increase the blood concentration of the ubiquinol form of Coenzyme Q10. It is not necessary to take a ubiquinol supplement in order to get enough ubiquinol.
  3. Coenzyme Q10 supplementation has significantly improved symptoms and survival in chronic heart failure patients (Q-Symbio Study) and significantly reduced cardiovascular mortality and improved heart function in community living senior citizens (KiSel-10 Study). Reduction of oxidative stress and systemic inflammation may be biological mechanisms that contributed to the positive clinical outcomes in these studies.

Sources

Akbari A, Mobini GR, Agah S, Morvaridzadeh M, Omidi A, Potter E, Fazelian S, Ardehali SH, Daneshzad E, Dehghani S. Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials. Eur J Clin Pharmacol. 2020 Nov;76(11):1483-1499.

Dludla PV, Orlando P, Silvestri S, Marcheggiani F, Cirilli I, Nyambuya TM, Mxinwa V, Mokgalaboni K, Nkambule BB, Johnson R, MazibukoMbeje SE, Muller CJF, Louw J, Tiano L. Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates inflammation and lipid peroxidation in Conditions of metabolic syndrome: A Meta-Analysis of randomized controlled trials. Int J Mol Sci. 2020 May 4;21(9):3247.

Dludla PV, Nyambuya TM, Orlando P, Silvestri S, Mxinwa V, Mokgalaboni K, Nkambule BB, Louw J, Muller CJF, Tiano L. The impact of Coenzyme Q10 on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta-analysis of randomized controlled trials. Endocrinol Diabetes Metab. 2020 Mar 14;3(2):e00118.

Hajiluian G, Heshmati J, Jafari Karegar S, Sepidarkish M, Shokri A, Shidfar F. Diabetes, Age, and Duration of Supplementation Subgroup Analysis for the Effect of Coenzyme Q10 on Oxidative Stress: A Systematic Review and Meta-Analysis. Complement Med Res. 2021 Apr 16:1-14.

Sangsefidi ZS, Yaghoubi F, Hajiahmadi S, Hosseinzadeh M. The effect of Coenzyme Q10 supplementation on oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Food Sci Nutr. 2020 Mar 19;8(4):1766-1776.

The information presented in this review article is not intended as medical advice and should not be used as such.

15 August 2021

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