In this article, I look back over the past 80 q10facts.com articles and pick out my favorites. Together, these articles give a good picture of what I have tried to present on this website: documented results from scientific studies of the absorption, safety, and efficacy of Coenzyme Q10 supplements in the form of Ubiquinone, the oxidized form of Coenzyme Q10, expressed as Q10 or CoQ10, is absolutely essential for the mitochondrial ATP energy production process. Ubiquinone is the form of Coenzyme Q10 that the body synthesizes, and ubiquinone is the form of Coenzyme Q10 that has been extensively tested for safety, absorption, and efficacy in clinical trials.... Read more about this term. At the present time, there simply is not the same quality or quantity of research results related to the use of Coenzyme Q10 supplements in the ubiquinol form.
Coenzyme Q10’s therapeutic value
This article summarized the clinical research evidence for the use of Coenzyme Q10 as an adjunctive therapy for the following patients:
- The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term patients
- Ischemic heart disease is heart disease caused by reduced blood flow to the heart. Ischemic heart disease is, in most cases, coronary artery disease. Blockage of the coronary arteries reduces the flow of blood and oxygen to the heart.... Read more about this term patients
- patients taking statin medications
- patients with high blood pressure
- patients scheduled for heart surgery
- patients with low energy syndrome
Coenzyme Q10: It’s the formulation that’s important!
For the most part, the quality of the Coenzyme Q10 raw material is not the issue. The issue is that the Coenzyme Q10 raw material is difficult to process into a supplement that is going to be absorbed and thus be bio-available. Without absorption and bio-availability to the cells, there to be no beneficial health effect from taking the Coenzyme Q10 supplement. Everything depends on the way in which the producer of the Coenzyme Q10 capsules pre-heats and dissolves the crystalline raw material in vegetable oils and seals the dissolved Coenzyme Q10 molecules inside the gelatin capsules. The key is keeping the Coenzyme Q10 molecules from re-crystallizing. The human body cannot absorb crystals the size of the Coenzyme Q10 crystals. It can absorb Coenzyme Q10 only as single molecules.
Coenzyme Q10 and people taking statin medications
Two things in particular affect the levels of Coenzyme Q10 in the blood and in the tissues: increasing age beyond the age of 20 and the taking of statin medications. The body’s synthesis of Coenzyme Q10 begins to taper off with increasing age in the adult years. As it happens, Coenzyme Q10 and cholesterol are produced in the same biological pathway. The statin medications that block the body’s production of Cholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... Read more about this term also block the body’s production of Coenzyme Q10. Even with reduced cholesterol levels, the body needs adequate levels of Coenzyme Q10 for cellular energy production and for Antioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term defense. There is clinical research evidence for the effectiveness of Coenzyme Q10 supplementation in addressing declines in the body’s own production of the substance.
Notably, Dr. Alehagen et al have shown in the KiSel-10 study that home-living elderly citizens benefit from taking a daily supplement combination of Coenzyme Q10 and selenium. Dr. Pourmoghaddas et al have shown that a combination of atorvastatin and Coenzyme Q10, taken as an adjunctive treatment to conventional treatment for The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term, increases heart function compared with the use of atorvastatin alone and conventional heart failure treatment.
Coenzyme Q10 in its two forms: ubiquinone and ubiquinol
The as yet unresolved controversy in the field of nutritional supplements is which form of Coenzyme Q10 to take. The solid documented research results showing beneficial health effects – the Morisco study, the Q-Symbio study, the KiSel-10 study, and the Gulf War Veterans study – have all come from studies using the ubiquinone form of Coenzyme Q10. The ubiquinol form has been extensively marketed, often with undocumented or poorly documented claims, and, in some cases, the ubiquinol supplements have contained substances that boost testosterone, leading to confusion as to whether the palpable effect of the supplement comes from the ubiquinol or the other substance.
But we have not seen persuasive randomized controlled studies showing the health effects from ubiquinol supplements that we have seen from ubiquinone supplements. Furthermore, research results indicate that the Coenzyme Q10 in ubiquinol supplements is converted in the stomach and the small intestine to ubiquinone prior to absorption, begging the question of why one should take a ubiquinol supplement in the first place. After all, the absorbed ubiquinone will be converted to the ubiquinol form in the lymph and will be in the ubiquinol form in the blood circulation. When the Coenzyme Q10 passes from the blood to the cells and tissues, it must be converted to ubiquinone for use in the process of cellular energy production. This conversion from ubiquinol back to ubiquinone takes places either through the action of special reductase enzymes or through ubiquinol’s neutralizing of Free radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... Read more about this term.
Coenzyme Q10 and Selenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... Read more about this term best together
Coenzyme Q10 is an essential bio-nutrient, necessary for cellular energy production and for antioxidant defense against harmful free radicals. One theory of heart failure posits that the heart muscle, lacking adequate quantities of Coenzyme Q10, is starved for energy. Daily supplementation of chronic heart failure patients with Coenzyme Q10 for two years led to significant improvement of symptoms and survival in the Q-Symbio study.
Selenium is an essential component of important proteins including the antioxidant enzyme glutathione peroxidases and selenoprotein P. Dr. Urban Alehagen, the lead researcher for the The KiSel-10 study was a four-year randomized, double-blind, placebo-controlled study of 443 Swedish citizens aged 70 to 88 who received either a combined daily supplementation of high-selenium yeast and Coenzyme Q10 or matching placebos. The elderly Swedish citizens who received the active treatment of selenium and Coenzyme Q10 had significantly reduced risk of death from heart disease, significantly better heart... Read more about this term, points out that increased oxidative stress is present in heart failure patients and in ischemic heart disease patients. For these patients, Dr. Alehagen suggests that deficiencies of the two antioxidant substances, selenium and Coenzyme Q10, seems to be The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... Read more about this term. Supplementation of home-living elderly study participants with a combination of Coenzyme Q10 and selenium resulted in a reduction of death from heart disease, in better heart function, and in lower levels of a bio-marker for heart disease.
Professor Alehagen posits a special inter-relationship between Coenzyme Q10 and selenium that makes using both substances as an intervention potentially beneficial. In the KiSel-10 study, treatment with both substances led to a reduction in cardiovascular deaths, to better cardiac function, and to lower concentrations of a bio-marker of heart failure.
Coenzyme Q10: Six treatment options
Dr. Svend Aage Mortensen, lead researcher for the Q-Symbio study of Coenzyme Q10 supplementation of heart failure patients, listed and discussed six different treatment modalities for which Coenzyme Q10 can be important:
- Preventative treatment in statin therapy
- Adjunctive treatment of ischemic heart disease and angina pectoris
- Pretreatment for coronary artery bypass surgery or valve surgery
- Adjunctive treatment in arterial Hypertension is abnormally high blood pressure, usually defined as adult systolic blood pressure above 140 mm Hg or adult diastolic blood pressure above 90 mm Hg. Systolic blood pressure is blood pressure measured during the contracting (pumping) of the left ventricle of the heart. Diastolic blood pressure is blood pressure measured during the relaxation of the left ventricle. A meta-analysis... Read more about this term
- Preventative treatment in anthracycline therapy
- Adjunctive treatment in chronic heart failure
Coenzyme Q10 research results published in bio-medical journals
The research results summarized on the website q10facts.com are results from Randomized controlled trials are studies in which patients or healthy volunteers are assigned at random (purely by chance) to receive one or more clinical interventions. One or more of the interventions is the active treatment being tested. Another of the interventions is the control against which the active treatment is being tested. The control is, typically, the standard practice or... Read more about this term that have been published in scholarly, peer-reviewed bio-medical journals. The website has never been used to present undocumented marketing claims.
Coenzyme Q10: a beautiful substance
Coenzyme Q10 is an essential substance for human health and survival. It is synthesized in the body, but the body’s ability to produce it declines with increasing age in the adult years. It is a redox substance that converts back and forth between its oxidized form, ubiquinone, the form needed for cellular energy production, and its reduced form, ubiquinol, the form needed for antioxidant purposes.
Fortunately, there are well-formulated supplements available that are safe, effective, and affordable. And, bear in mind, it is the formulation of the Coenzyme Q10 capsules that is decisive in the effectiveness of the supplement.
Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., & Dahlström, U. (2013). Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized A double-blind study is a study in which neither the investigators nor the study participants know which participants are receiving the active treatment and which participants are receiving the control treatment until the study has been completed and the seal on the code has been broken.... Read more about this term placebo-controlled trial among elderly Swedish citizens. International Journal of Cardiology, 167(5), 1860-1866.
Alehagen, U., & Aaseth, J. (2015). Selenium and coenzyme Q10 interrelationship in cardiovascular diseases–A clinician’s point of view. Journal of Trace Elements in Medicine And Biology, 31157-162.
Folkers, K., Vadhanavikit, S., & Mortensen, S. A. (1985). Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proceedings of The National Academy of Sciences of The United States of America, 82(3), 901-904.
Golomb, B. (2014, Nov.). Coenzyme Q10 and Gulf War Illness. Neural Computation, 26 (11), 2594-651.
Kalen A, Appelkvist EL, Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids. 1989;24(7):579–584.
Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., & … Littarru, G. P. (2014). The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC. Heart Failure, 2(6), 641-649.
Singh, R. B.,Niaz, M. A., Sindberg, C. D., Moesgaard, S. & Littarru, G. P. (2005). Effect of oral coenzyme Q10 dosages on serum Q10 and MDA levels among healthy men. Paper presented at the International Coenzyme Q10AssociationMeeting Abstracts, Los Angeles.
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