A well-formulated ubiquinone Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term supplement was absorbed significantly better than a well-formulated ubiquinol supplement. This is one of the take-home messages from a recent carefully designed Spanish university study [Lopez-Lluch 2018].
Remember: Ubiquinol supplements are notoriously difficult to work with. As an antioxidant posed to give up its two extra electrons, ubiquinol is by its very nature unstable. Often, the ubiquinol is oxidized (gives up its electrons) while still in the soft-gel capsule.
If the contents of the ubiquinol capsule look yellow or orange, then the ubiquinol in the capsule has changed to the ubiquinone form. The ubiquinol should be milky white inside the capsule.
Dr. Judy’s lab and dog studies of ubiquinol
The following progression of oral ubiquinol from supplements has been shown in Dr. William Judy’s lab studies and large dog studies:
- The ubiquinol is almost completely converted to the ubiquinone form of Coenzyme Q10 when it is exposed to the gastric juices in the stomach and the duodenum.
- The Coenzyme Q10 from the ubiquinol supplement is absorbed in the jejunum while still in the ubiquinone form.
- The ubiquinone Coenzyme Q10 is then converted back to the ubiquinol form as the CoQ10 passes into the lymph and makes its way to the blood circulation.
Note: The dogs used in the studies were not anesthetized, were not harmed, and were not sacrificed.
Begs the question: why ubiquinol?
Dr. Judy’s lab studies and dog studies raise the question: why buy a ubiquinol product? A well-formulated ubiquinone CoQ10 preparation will raise the concentration of the antioxidant form of CoQ10, the ubiquinol form, in the blood significantly.
Ubiquinone CoQ10 supplementation and increases in ubiquinol concentrations
Dr. Roland Stocker and his colleagues were the first to show, already in the early 1990’s, that the administration of ubiquinone CoQ10 raises the levels of ubiquinol (the reduced form of CoQ10) in the plasma and in the Lipoproteins are particles comprised of protein and lipids, with a core of triglycerides and cholesterol esters and an outer layer of phospholipids. Lipoproteins transport lipids through the bloodstream. LDL-lipoproteins carry cholesterol from the liver to the body tissues. HDL- lipoproteins carry cholesterol back to the liver from the body tissues. LDL-lipoproteins also bind and transport Coenzyme Q10 molecules, predominately in... Read more about this term [Mohr 1992].
People who want the antioxidant protection of the ubiquinol form of CoQ10 can rest assured that taking a well-formulated ubiquinone CoQ10 supplement will give them that protection.
Different forms and different formulations of CoQ10
Fact: CoQ10 supplements differ as to form:
- ubiquinone form: the stable, much tested form
- ubiquinol form: the unstable, much less tested form
Fact: CoQ10 supplements differ as to composition and formulation.
The recently completed Spanish university study compared not only different forms of CoQ10 supplements – ubiquinone and ubiquinol – but also variously formulated ubiquinone CoQ10 supplements.
The ubiquinone CoQ10 supplements that were tested for absorption differed in the composition of the oils used to dissolve the CoQ10 raw material and in the extent to which the oils containing the CoQ10 were pre-heated prior to being filled into capsules.
The best ubiquinone CoQ10 formulation
The best ubiquinone CoQ10 formulation, the one that was absorbed nearly twice as well as the ubiquinol formulation, also out-performed five other ubiquinone CoQ10 supplements [Lopez-Lluch 2018].
The best formulated ubiquinone CoQ10 supplement gave an absorption that was about three times better than the absorption of any of the other ubiquinone CoQ10 supplements tested [Lopez-Lluch 2018].
Formulation of CoQ10 preparations even more important than form?
It should be noted that the ubiquinol supplement also out-performed the five ubiquinone CoQ10 supplements.
Given this outcome, it is fair to conclude that the composition and the formulation of the CoQ10 supplement is even more important for absorption than the form of the CoQ10.
Health effects of CoQ10 supplementation most important
Okay, we test the absorption of Coenzyme Q10 because consumers want to know that the substance is not just eliminated.
But, we know that the reason consumers take CoQ10 supplements is for the health benefits:
- Improved symptoms and survival for The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term patients [Mortensen 2014]
- Better heart health for elderly citizens [Alehagen 2013, 2018]
- Increased physical function for Gulf War Illness patients [Golomb 2013]
- Protection against adverse effects of statin medications [Okuyama 2015]
- Lower blood pressure [Rosenfeldt 2007]
- Reduced Migraine headaches are defined as unprovoked headaches that typically last from one to three days and are severe enough to limit or halt routine daily activity. Typically, too, migraine headaches are accompanied by nausea and sensitivity to light and sound. Studies have shown that CoQ10 supplementation can help to prevent and treat migraine headache. CoQ10 supplements have had statistically significant... Read more about this term frequency and intensity [Sandor 2005]
Same ubiquinone CoQ10 product used
The best-absorbed ubiquinone Coenzyme Q10 supplement in the Spanish university study is the same ubiquinone formulation that showed The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... Read more about this term health effects in randomized controlled studies:
- Q-Symbio chronic heart failure study [Mortensen 2014]
- KiSel-10 senior citizens study [Alehagen 2013, 2018]
- Gulf War Illness study [Golomb 2014]
Alehagen, U., Aaseth, J., Alexander, J., & Johansson, P. (2018). Still reduced cardiovascular mortality 12 years after supplementation with Selenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... Read more about this term and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized A double-blind study is a study in which neither the investigators nor the study participants know which participants are receiving the active treatment and which participants are receiving the control treatment until the study has been completed and the seal on the code has been broken.... Read more about this term placebo-controlled trial in elderly. Plos One, 13(4), e0193120. doi:10.1371/journal.pone.0193120
Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., & Dahlström, U. (2013). Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. International Journal of Cardiology, 167(5), 1860-1866.
Golomb, B. CoQ10 and gulf war illness. Neural Computation 2014 Nov; Vol. 26 (11), pp. 2594-651
López-Lluch, G., Del Pozo-Cruz, J., Sánchez-Cuesta, A., Cortés-Rodríguez, A. B., & Navas, P. (2019). Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition, 57, 133–140.
Mohr, D., Bowry, V. W., & Stocker, R. (1992). Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of Oxidation is the chemical reaction of a substance with oxygen. Peroxidation is the extreme form of oxidation that results from free radicals’ stealing electrons from lipids, either in the cell membranes or in the lipoproteins. The final product of lipid peroxidation is highly reactive malondialdehyde, a bio-marker for oxidative stress and damage.... Read more about this term. Biochimica et Biophysica Acta, 1126(3), 247-254.
Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., & Littarru, G. P. (2014). The effect of coenzyme Q10 on morbidity and mortality in The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term: results from Q-SYMBIO: a randomized double-blind trial. JACC. Heart Failure, 2(6), 641-649.
Okuyama, H., Langsjoen, P. H., Hamazaki, T., Ogushi, Y., Hama, R., Kobayashi, T., & Uchino, H. (2015). Statins are a class of medications that effectively block the body’s synthesis of cholesterol. In so doing, statins also block the body’s synthesis of Coenzyme Q10.... Read more about this term stimulate Atherosclerosis is the thickening of the artery walls brought about by the build-up of plaque (plaque is made up of cholesterol and other fatty substances and waste products and calcium and fibrin) and the subsequent slowing of the flow of blood through the clogged arteries. More research is needed into the role of Coenzyme Q10 in the prevention and adjunct... Read more about this term and heart failure: pharmacological mechanisms. Expert Review of Clinical Pharmacology, 8(2), 189-199.
Rosenfeldt, FL et al. Coenzyme Q10 in the treatment of Hypertension is abnormally high blood pressure, usually defined as adult systolic blood pressure above 140 mm Hg or adult diastolic blood pressure above 90 mm Hg. Systolic blood pressure is blood pressure measured during the contracting (pumping) of the left ventricle of the heart. Diastolic blood pressure is blood pressure measured during the relaxation of the left ventricle. A meta-analysis... Read more about this term: a meta-analysis of the clinical trials. Journal of Human Hypertension, 2007, 21: 297-306.
Sándor, P. S., Di Clemente, L., Coppola, G., Saenger, U., Fumal, A., Magis, D., & Schoenen, J. (2005). Efficacy of Coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology, 64(4), 713-715.
Disclaimer: The information contained in this review article is not intended as medical advice and should not be construed in that way.Please click here for more information about the heart health benefits of Coenzyme Q10 supplementation.