Coenzyme Q10 Supplementation Increases ATP Levels

Fact: Adequate Coenzyme Q10 is essential for our cells’ generation of ATP energy.

Roger Federer
For cells and tissues with high energy needs, tissues such as heart muscle tissue and skeletal muscle tissue, there is a constant demand for CoQ10 molecules.

Adenosine triphosphate (ATP) molecules have been called the energy currency of the cells. ATP molecules have to be produced and stored for later use, similar to storing money in a bank. All of our cells contain ATP, and the ATP provides the energy for almost all cellular processes. ATP is, so to speak, what drives the cellular machinery.

CoQ10 molecules are vitamin-like substances that are an essential component of the oxidative phosphorylation process in the cells’ mitochondria; they are essential to the process that converts the energy from ingested carbohydrates and fatty acids into ATP [Schniertshauer 2016].

read more

The Instability of Ubiquinol, Part 2 – Dog Studies

The results from large dog studies done by SIBR Research show that orally administered ubiquinol is mostly converted to the ubiquinone form of Coenzyme Q10 by the time it reaches the small intestines [Judy 2021 Part 2].

Dr Judy in the lab
Coenzyme Q10 is an essential bio-nutrient, especially important as we get older. It is a redox molecule with an oxidized state called ubiquinone and a reduced state called ubiquinol. Both are bio-active states. Ubiquinone supplements are more stable and much more tested than ubiquinol supplements. Ubiquinol by nature of being an electron donor is relatively quick to be oxidized to ubiquinone.

In the small intestines, it is then absorbed primarily as ubiquinone. Once it enters the lymph, it is increasingly converted back to ubiquinol.

By the time it leaves the lymph to enter the blood circulation, it is approximately 96 % ubiquinol again.

These findings beg the question: why buy a ubiquinol supplement when the ubiquinol will probably be converted to the ubiquinone form of Coenzyme Q10 prior to absorption?

read more

Coenzyme Q10 Supplementation for Elderly Persons

Supplementation with Coenzyme Q10 has primarily made use of the oxidized form called ubiquinone. It is the stable form of Coenzyme Q10, the form with which all the important clinical studies have been done involving elderly persons, heart failure patients, and Gulf War Illness patients [Alehagen 2013; Golomb 2014; Mortensen 2014].

Walk in autumn weather
When we reach the September of our years, our cells synthesize less and less of Coenzyme Q10, the essential bio-nutrient that is needed for ATP energy generation, for antioxidant defense against harmful free radicals, and for anti-inflammatory effects.

In study participants with low baseline selenium status, the combination of Coenzyme Q10 together with the essential trace element selenium appears to reduce the level of oxidative stress and inflammation and to delay or ameliorate the development of some age-related disorders [Aaseth 2021].

read more

Coenzyme Q10 Supplementation for Fibromyalgia Patients

Fibromyalgia is a common chronic pain condition without a known cause and without a reliable, effective medical treatment. It has several signs and symptoms in common with chronic fatigue syndrome: fatigue, pain, weakness, a feeling of discomfort in the body, a sense of unease and/or anxiety and depression.

Woman suffering from fibromyalgia
Treatment of fibromyalgia generally involves physiotherapy, anti-convulsants, and antidepressant therapy. Adequate intake of Coenzyme Q10, magnesium, selenium, vitamin D, and vitamin B12 may be beneficial.

Mitochondrial dysfunction, oxidative stress, and inflammation have been associated with fibromyalgia.

CoQ10 supplementation may restore an underlying deficit in CoQ10 status, which has been associated with fibromyalgia, and may improve the fibromyalgia patient’s outlook by:

read more

The Instability of Ubiquinol Supplements – Lab Studies

At SIBR Research, we have long been concerned about misleading claims for ubiquinol supplements on the Web. It seems that there is a lack of understanding of the processes influencing the absorption and subsequent metabolism of ubiquinol. Moreover, this misunderstanding seems to have been exacerbated by some manufacturers’ incorrect claims regarding the bioavailability of their ubiquinol supplements [Mantle & Dybring 2020].

Dr William V Judy
SIBR Research studies show that the ubiquinol in supplements is very likely to be converted to ubiquinone in the small intestines, to be absorbed as ubiquinone, and then to be converted back to ubiquinol in the lymph.

Basic Information about Ubiquinone and Ubiquinol

  • Ubiquinol is the reduced form of Coenzyme Q10; it is the antioxidant form of Coenzyme Q10.
  • Ubiquinone is the oxidized form of Coenzyme Q10. It is essential for the process of ATP energy generation.

Note: Both forms of Coenzyme Q10 are bio-active forms.

Ubiquinone More Stable than Ubiquinol in Supplements

Ubiquinol molecules are electron donors. Thus, they are inherently unstable. They are constantly looking to give up two electrons. It is this property that first made us wonder whether the ubiquinol in supplements actually gets absorbed as ubiquinol or gets converted to ubiquinone before being absorbed.

read more

Coenzyme Q10 for Traumatic Injury Patients in the Intensive Care Unit

The administration of supplemental Coenzyme Q10 in addition to conventional medical treatment has beneficial effects on traumatic injury patients in the intensive care unit and has no observed adverse effects.

Intubation
Prolonged mechanical ventilation of patients in intensive care units can have adverse effects. In this study, administration of 400 milligrams of Coenzyme Q10 daily significantly reduced the length of stay in the intensive care unit and the duration of the mechanical ventilation.

This is the conclusion from a clinical trial that enrolled patients who had been admitted to the intensive care unit [Hasanloei 2021].

The problem: trauma

-Traumatic injury is not uncommon: nearly one-third of the patients admitted to a typical intensive care unit in pre-Covid 19 days were admitted with traumatic injuries of one type or another.

read more

Coenzyme Q10 and NADH in Chronic Fatigue Syndrome

Both Coenzyme Q10 and NADH blood levels have been shown to be sub-optimal in patients diagnosed with chronic fatigue syndrome [Castro-Marrero 2013; Maes 2009].

Dr. William V. Judy
Dr. Judy regards mitochondrial dysfunction, reduced immune function, and increased oxidative stress as biological explanations for the inverse association between CoQ10 and NADH status and the severity of chronic fatigue syndrome.

In chronic fatigue syndrome, patients have the following symptoms:

  • fatigue that persists even after rest and sleep
  • generalized chronic pain
  • lack of motivation for physical and mental exertion
  • disruptions in concentration and memory
  • changes in sleep patterns and duration

Chronic fatigue syndrome is a severe disabling condition without a good prognosis. There is no universally recognized treatment mode.

CoQ10 and NADH Combined Supplementation in Chronic Fatigue Syndrome

Now a randomized controlled trial published in 2021 shows that supplementation of chronic fatigue syndrome patients with 200 mg of Coenzyme Q10 and 20 mg of NADH daily for 12 weeks has statistically significant health benefits:

read more

Coenzyme Q10 for Pets and Farm Animals and Race Horses

Back in November of 2020, q10facts.com ran a story about the experimental use of CoQ10 supplementation in dogs, Cavalier King Charles Spaniels with mitral valve disease, to be precise. The study results showed that 2 times 100 mg daily had significantly raised the animals’ blood CoQ10 concentrations [Christiansen 2020]. Here we write about Coenzyme Q10 for pets and farm animals and race horses.

Dr. William Judy
Guest author Dr. William Judy, President of SIBR Research and Coenzyme Q10 researcher for over 40 years. Here, lecturing at an International Coenzyme Q10 Association conference in Bologna, Italy.

Coenzyme Q10 and Danny the Sheep

Just recently, I received an email about the CoQ10 experiences of a sheep farmer in the North of England who writes as follows:

read more

Covid-19 and Coenzyme Q10 and Selenium

In the UK, biochemist Iain R. Hargreaves and medical doctor David Mantle have written that the initial immune system response to the Covid-19 virus and the subsequent resolution of the resulting inflammation may well be dependent upon nutritional status, including micronutrient status. Accordingly, they have investigated the relationship between the status of two micronutrients, Coenzyme Q10 and selenium, and the effect on oxidative stress and inflammation [Hargreaves & Mantle 2021].

Covid-19 test
In a 2021 review article, Hargreaves and Mantle write that adequate intakes of both Coenzyme Q10 and selenium are necessary for optimal immune system defense against Covid-19 infections.

They conclude that optimal status of both Coenzyme Q10 and selenium may be one aspect of an effective program to prevent and treat Covid-19 infections [Hargreaves & Mantle 2021]. The important thing in dealing with Covid-19 infections is to achieve and maintain a balance in the immune response against the virus without causing a cytokine storm as the cytokine storm is the cause of lung injury and respiratory distress in severe cases.

read more

Coenzyme Q10 Protects Against Oxidative Stress and Inflammation

Herewith summaries of 2020-2021 meta-analyses of randomized controlled trials of Coenzyme Q10 supplementation for protection against oxidative stress and chronic inflammation. Note: A meta-analysis is a specific procedure for the pooling and evaluating of data from many individual studies for the purpose of getting more precise results.

CoQ10 and Protection Against Oxidative Stress

Hajiluian et al. investigated the antioxidant effect of CoQ10 supplementation in an analysis of 17 randomized controlled trials enrolling 972 participants. The aggregated data showed that CoQ10 supplementation is associated significantly with increased serum total antioxidant capacity, with increased superoxide dismutase levels, and with decreased malondialdehyde levels compared to the placebo group. The researchers concluded that CoQ10 supplementation improves antioxidant protection against oxidative damage caused by reactive oxygen species.

read more