Coenzyme Q10 and NADH in Chronic Fatigue Syndrome

Both Coenzyme Q10 and NADH blood levels have been shown to be sub-optimal in patients diagnosed with chronic fatigue syndrome [Castro-Marrero 2013; Maes 2009].

Dr. William V. Judy
Dr. Judy regards mitochondrial dysfunction, reduced immune function, and increased oxidative stress as biological explanations for the inverse association between CoQ10 and NADH status and the severity of chronic fatigue syndrome.

In chronic fatigue syndrome, patients have the following symptoms:

  • fatigue that persists even after rest and sleep
  • generalized chronic pain
  • lack of motivation for physical and mental exertion
  • disruptions in concentration and memory
  • changes in sleep patterns and duration

Chronic fatigue syndrome is a severe disabling condition without a good prognosis. There is no universally recognized treatment mode.

CoQ10 and NADH Combined Supplementation in Chronic Fatigue Syndrome

Now a randomized controlled trial published in 2021 shows that supplementation of chronic fatigue syndrome patients with 200 mg of Coenzyme Q10 and 20 mg of NADH daily for 12 weeks has statistically significant health benefits:

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