Coenzyme Q10 for Traumatic Injury Patients in the Intensive Care Unit

The administration of supplemental Coenzyme Q10 in addition to conventional medical treatment has beneficial effects on patients with traumatic injury and has no observed adverse effects.

Intubation
Prolonged mechanical ventilation of patients in intensive care units can have adverse effects. In this study, administration of 400 milligrams of Coenzyme Q10 daily significantly reduced the length of stay in the intensive care unit and the duration of the mechanical ventilation.

This is the conclusion from a clinical trial that enrolled patients who had been admitted to the intensive care unit [Hasanloei 2021].

The problem: trauma

-Traumatic injury is not uncommon: nearly one-third of the patients admitted to a typical intensive care unit in pre-Covid 19 days were admitted with traumatic injuries of one type or another.

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Coenzyme Q10 and NADH in Chronic Fatigue Syndrome

Both Coenzyme Q10 and NADH blood levels have been shown to be sub-optimal in patients diagnosed with chronic fatigue syndrome [Castro-Marrero 2013; Maes 2009].

Dr. William V. Judy
Dr. Judy regards mitochondrial dysfunction, reduced immune function, and increased oxidative stress as biological explanations for the inverse association between CoQ10 and NADH status and the severity of chronic fatigue syndrome.

In chronic fatigue syndrome, patients have the following symptoms:

  • fatigue that persists even after rest and sleep
  • generalized chronic pain
  • lack of motivation for physical and mental exertion
  • disruptions in concentration and memory
  • changes in sleep patterns and duration

chronic fatigue syndrome is a severe disabling condition without a good prognosis. There is no universally recognized treatment mode.

CoQ10 and NADH Combined Supplementation in Chronic Fatigue Syndrome

Now a randomized controlled trial published in 2021 shows that supplementation of chronic fatigue syndrome patients with 200 mg of Coenzyme Q10 and 20 mg of NADH daily for 12 weeks has statistically significant health benefits:

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Coenzyme Q10 for Pets and Farm Animals and Race Horses

Back in November of 2020, q10facts.com ran a story about the experimental use of CoQ10 supplementation in dogs, Cavalier King Charles Spaniels with mitral valve disease, to be precise. The study results showed that 2 times 100 mg daily had significantly raised the animals’ blood CoQ10 concentrations [Christiansen 2020].

Dr. William Judy
Guest author Dr. William Judy, President of SIBR Research and Coenzyme Q10 researcher for over 40 years. Here, lecturing at an International Coenzyme Q10 Association conference in Bologna, Italy.

Coenzyme Q10 and Danny the Sheep

Just recently, I received an email about the CoQ10 experiences of a sheep farmer in the North of England who writes as follows:

Danny is a three-year-old sheep. Danny developed severe swelling on both sides of his abdomen, he had difficulty standing, and he lost interest in his feed. He was seen by the local vet, who diagnosed heart failure and said Danny was going to die within the next week or so. There is no veterinary treatment for sheep with heart failure.

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Covid-19 and Coenzyme Q10 and Selenium

In the UK, biochemist Iain R. Hargreaves and medical doctor David Mantle have written that the initial immune system response to the Covid-19 virus and the subsequent resolution of the resulting inflammation may well be dependent upon nutritional status, including micronutrient status. Accordingly, they have investigated the relationship between the status of two micronutrients, Coenzyme Q10 and selenium, and the effect on oxidative stress and inflammation [Hargreaves & Mantle 2021].

Covid-19 test
In a 2021 review article, Hargreaves and Mantle write that adequate intakes of both Coenzyme Q10 and selenium are necessary for optimal immune system defense against Covid-19 infections.

They conclude that optimal status of both Coenzyme Q10 and selenium may be one aspect of an effective program to prevent and treat Covid-19 infections [Hargreaves & Mantle 2021]. The important thing in dealing with Covid-19 infections is to achieve and maintain a balance in the immune response against the virus without causing a cytokine storm as the cytokine storm is the cause of lung injury and respiratory distress in severe cases.

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Coenzyme Q10 Protects Against Oxidative Stress and Inflammation

Herewith summaries of 2020-2021 meta-analyses of randomized controlled trials of Coenzyme Q10 supplementation for protection against oxidative stress and chronic inflammation. Note: A meta-analysis is a specific procedure for the pooling and evaluating of data from many individual studies for the purpose of getting more precise results.

CoQ10 and Protection Against Oxidative Stress

Hajiluian et al. investigated the antioxidant effect of CoQ10 supplementation in an analysis of 17 randomized controlled trials enrolling 972 participants. The aggregated data showed that CoQ10 supplementation is associated significantly with increased serum total antioxidant capacity, with increased superoxide dismutase levels, and with decreased malondialdehyde levels compared to the placebo group. The researchers concluded that CoQ10 supplementation improves antioxidant protection against oxidative damage caused by reactive oxygen species.

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Coenzyme Q10 and Immune Function

Coenzyme Q10 supplementation is especially well-regarded for the prevention and adjunctive treatment of heart failure [Mortensen 2014; Mortensen 2019].

Insider's Guide to Coenzyme Q10
The best guide to clinical studies of Coenzyme Q10 supplementation is Dr. William Judy’s Insider’s Guide to Coenzyme Q10, available from amazon.com. ISBN: 978-87-7776-186-7.

Administration of Coenzyme Q10 is also recommended for the treatment of statin-associated muscle symptoms [Raizner & Quiñones 2021].

Randomized controlled clinical studies have also shown that CoQ10 supplementation can help to prevent or treat such disorders as diabetes [Mantle 2017], non-alcoholic fatty liver disease [Mantle 2020], chronic kidney disease [Hargreaves 2019], and migraine [Sazali 2021].

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Coenzyme Q10 and Male Infertility

There is more and more evidence that Coenzyme Q10 plays a physiological role in the maintenance of semen quality [Alahmar 2021]:

  • Higher CoQ10 concentrations in seminal plasma correlate directly with elevated semen parameters such as sperm motility and sperm count.
  • Seminal CoQ10 concentrations are sub-optimal in male infertility conditions.
Pregnant woman
Infertility affects an estimated 15% of couples worldwide. Male infertility is a factor in about 50% of cases. The causes of male infertility are poorly understood, but there is evidence that oxidative stress is related to poor seminal fluid quality. Coenzyme Q10 is a powerful antioxidant, reducing levels of oxidative stress.

In a 2021 review article, Alahmar et al. [2021] summarize the research into CoQ10’s role in the regulation of male reproductive function:

  • restores semen parameters in male infertility patients
  • reduces the blood levels of biomarkers for oxidative stress
  • improves pregnancy and assisted reproductive technology outcomes
  • reduces sperm DNA fragmentation

CoQ10 Effects on Sperm Parameters

Alahmar et al. [2021] have reviewed several clinical trials of the CoQ10 supplementation of patients with male infertility. Overall, the outcomes of these studies show the following beneficial effects:

  • increased concentrations of Coenzyme Q10 in the semen and in spermatozoa
  • enhanced sperm parameters: sperm concentration, motility, and morphology
  • improved oxidative stress bio-markers and increased protection against free radical-induced sperm damage

CoQ10 Effects on Sperm DNA Fragmentation

Current evidence shows that Sperm DNA Fragmentation plays a crucial role in male infertility. Oxidative stress may be the key mechanism causing the sperm DNA fragmentation. An excess of harmful free radicals may be causing kinks and breaks in sperm DNA.

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Dr. Judy: Coenzyme Q10 Supplements Against Heart Failure

Here, below, is what I have learned about Coenzyme Q10 over the years. CoQ10 is a naturally occurring redox compound that is essential for life in all humans. Dr. Karl Folkers called it “an essential bio-nutrient.”

  • Coenzyme Q10 in its ubiquinone form, its oxidized state, plays an essential role in the production of ATP energy. It is needed in optimal quantities for cellular bio-energetics in heart muscle and skeletal muscle tissue.
  • In its ubiquinol form, its reduced state, Coenzyme Q10 functions as a lipophilic antioxidant, scavenging harmful free radicals and providing protection against oxidative damage.
  • CoQ10 supplementation has been shown to improve endothelial function [Belardinelli 2008]. The endothelial cells line the inside of the heart and the blood vessels. They are the cells that release substances that regulate the contraction and relaxation of the blood vessels, and they release enzymes that regulate blood clotting and platelet adhesion. They are very important for good heart health.
  • In clinical trials, CoQ10 supplementation has been associated with anti-inflammatory effects. A meta-analysis of 17 clinical trials has shown that CoQ10 status is associated significantly with reduced levels of the inflammatory mediators C-reactive protein, interleukin-6, and tumor necrosis factor-α [Fan 2017].
Dr. William Judy lecturing
In addition to doing clinical research into the efficacy of Coenzyme Q10 supplementation for some 40 years, early on in my career, I developed and refined a method of bio-electrical impedance measurement. I was able to use this non-invasive method to evaluate heart function in Black Lung Disease patients, in participants in the NASA Apollo program, and in open heart surgery patients in recovery. My message: use Coenzyme Q10 to ward off heart problems.

Blood and Tissue Deficiencies of Coenzyme Q10

  • Blood and tissue CoQ10 deficiency can occur because of ageing and because of the effect of medications such as statins.
  • Blood and tissue CoQ10 deficiency have been associated with statin-associated muscle symptoms (muscle aches and pains, severe cramps, muscle weakness) and with some of the symptoms of patients with heart failure and chronic fatigue syndrome (tiredness, fatigue, lack of energy).
  • Evidence from a 2016 meta-analysis supports the use of supplemental Coenzyme Q10 in patients with statin-associated muscle symptoms [Qu 2016].
  • The randomized controlled trial, the Q-Symbio Study, provides evidence for an adjunctive role for Coenzyme Q10 in the treatment of patients with chronic heart failure [Mortensen 2014].
  • A 2013 meta-analysis has shown that supplementation with Coenzyme Q10 resulted in significantly improved ejection fraction and improved NYHA functional class [Fotino 2013].

CoQ10 Supplementation of Patients with Statin-Associated Muscle Symptoms

Writing in February, 2021, in a special issue of one of the leading cardiology journals: Journal of the American College of Cardiology, Texas cardiologists Albert E. Raizner and Miguel A. Quiñones, conclude that it seems “reasonable and justifiable” for cardiologists to use Coenzyme Q10 supplements with patients diagnosed with statin-associated muscle symptoms [Raizner & Quiñones 2021].

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Coenzyme Q10 Supplementation in Ageing and Disease

In the Mechanisms of Ageing and Development journal, Professor Jan Aaseth, Professor Urban Alehagen, and I have published a review of the research literature relating to Coenzyme Q10 and aging. Here, I want to summarize the main points briefly.

Professor Jan Alexander
Dr. Jan Alexander is MD, PhD, ERT, and Professor at the Norwegian Institute of Public Health in Oslo. He is the co-author, together with Professor Urban Alehagen and Professor Jan Aaseth, of many articles about Coenzyme Q10 and selenium. (ERT stands for Eurotox Registered Toxicologist.)

What is Coenzyme Q10 and Why is it Important?

Coenzyme Q10 is a substance with vitamin-like effects on our health; however, our cells can synthesize Coenzyme Q10, so, by definition, it is not a vitamin. Among its important health-promoting effects are the following:

  • an essential component in the process of ATP energy generation
  • an important fat-soluble antioxidant in cellular membranes and lipoproteins
  • an anti-inflammatory agent

What Causes Sub-Optimal Coenzyme Q10 Levels?

Once we have passed our 20s, our cells’ ability to synthesize Coenzyme Q10 declines and decreases steadily with increasing age [Kalén 1989]. It is reasonable to think that most individuals in middle age and in their senior years might benefit from a CoQ10 supplement.

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Coenzyme Q10 and Female Infertility: Two Meta-Analyses

Compared with placebo or no-treatment, oral supplementation with Coenzyme Q10 can increase clinical pregnancy rates in women undergoing Assisted Reproductive Technology procedures [Florou 2020].

Pregnant woman
A good definition of female infertility is the failure to achieve pregnancy after 12 months of regular unprotected sexual intercourse. This failure to achieve pregnancy after 12 months of trying affects one out of six couples worldwide.

Compared to control study participants, women diagnosed with poor ovarian response undergoing controlled ovarian stimulation have better clinical outcomes in terms of pregnancy achievement and in terms of a lower dosage of gonadotrophin required for ovulation induction when Coenzyme Q10 is used as an adjuvant therapy [Zhang 2020].

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