Coenzyme Q10 Ameliorates Statin-Associated Muscle Symptoms

Richard Statins September 17, 2019September 17, 2019 0 Comment

In his 2018 book entitled Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical...: An Insider’s Guide, Dr. William V. Judy describes the complicated relationship between Coenzyme Q10 and statin medications. Please see pages 80-85. The book is available from amazon.com.

A 2018 meta-analysis and systematic review has shown that Coenzyme Q10 supplementation significantly ameliorates statin-induced muscle symptoms [Qu]:

reduces muscle pain
reduces muscle weakness
reduces muscle cramping
reduces muscle fatigue

The positive results of the meta-analysis suggest that Coenzyme Q10 supplementation may be a complementary approach to the management of statin-induced myopathy [Qu].

Why Do You Need Coenzyme Q10 Supplements with Statin Medication?

Statin medications are drugs widely prescribed in order to lower patients’ levels of total cholesterolCholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... More and the so-called “bad” ldl-cholesterol. StatinsStatins are a class of medications that effectively block the body’s synthesis of cholesterol. In so doing, statins also block the body’s synthesis of Coenzyme Q10.... are used to protect against heart attack and stroke; however, they do have adverse effects.

Coenzyme Q10 Crystals and Coenzyme Q10 Absorption

Richard Absorption September 9, 2019September 10, 2019 0 Comment

The Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... raw material is a yellow or orange crystalline powder produced by a yeast fermentation extraction process. The CoQ10 crystals are fat-soluble. They are practically insoluble in water, and any attempt to make them water-soluble will rob them of their CoQ10 characteristics. Coenzyme Q10 is soluble in lipids, but keeping the Coenzyme Q10 molecules from re-crystallizing inside the supplement capsules is difficult. And humans cannot absorb CoQ10 crystals, only single CoQ10 molecules.

Absorption of the Coenzyme Q10 in commercial nutritional supplements varies considerably. The dissolution of the CoQ10 crystals and the absorption of the Coenzyme Q10 molecules depend upon the composition of the oil matrix and the formulation of the CoQ10 nutritional supplement. The manufacturer of a CoQ10 supplement must deal with raw material that is very difficult to work with.

Coenzyme Q10 Soluble in Lipids at Higher Temperatures

Coenzyme Q10 is practically insoluble in water but is soluble in lipids; however, no individual lipids have been found in which 100 milligrams of Coenzyme Q10 can be dissolved so that the dissolved Coenzyme Q10 molecules inside the nutritional supplement capsules will not re-crystallize at normal storage temperatures: typically, between 60 and 75 degrees Fahrenheit.

Coenzyme Q10 Absorption, Efficacy, and Safety

Richard Absorption September 2, 2019September 2, 2019 0 Comment

A significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... More reduction in the rate of CoQ10 biosynthesis has been associated with the aging process and aging-related diseases [Hernandez-Camacho 2018]. It is not possible to make up for this loss of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... by eating more selectively. Supplementation with a well-formulated CoQ10 preparation is necessary. (Graph compliments of SIBR Research Institute)

The active substance in the best Coenzyme Q10 nutritional supplements is a natural substance extracted from a yeast fermentation process; it is not a synthetic substance.

The CoQ10 molecules in the best nutritional supplements are the same molecules as the CoQ10 molecules synthesized inside the mitochondriaThe mitochondria are the bean-shaped organelles in the cells. They are the key organelles with responsibility for the production of ATP energy molecules.... More in human cells.

Absorption and Bio-availability of Coenzyme Q10

Similar to vitamin EVitamin E is a fat-soluble vitamin that plays an important role as an antioxidant in the body. Vitamin E neutralizes harmful free radicals. Coenzyme Q10 regenerates Vitamin E after the vitamin E has neutralized free radicals...., Coenzyme Q10 in food and in nutritional supplements has a low absorption and bio-availability. In the case of Coenzyme Q10, the difficult absorption is attributed to the relatively large size and the lipid soluble nature of the CoQ10 molecules.

Coenzyme Q10 and Systemic Inflammation

Richard Inflammation August 4, 2019August 5, 2019 0 Comment

Professor Urban Alehagen, Linköping University, has reported that daily supplementation with Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... and high seleniumSelenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... yeast significantly reduces the blood concentrations of known bio-markers for systemic inflammationInflammation is an immune system response to an injury to cells or tissues. It is the body’s attempt to defend against invaders such as bacteria andviruses and to mend the damage done by invaders. Typically, inflammation manifests itself in the form of fever and swelling, in the swarming of white blood cells and the release of cytokines to fight against.... This anti-inflammatory effect may be one of the mechanisms by which Coenzyme Q10 supplementation protects the cardiovascular system.

Coenzyme Q10 supplementation with 100 – 300 milligrams daily promotes good heart health [Alehagen, Mortensen]. Supplementation is important because most of the body’s supply of Coenzyme Q10 comes from endogenous bio-synthesis, not from the diet, and, as we get older, our bodies produce less Coenzyme Q10 [Kalén].

The primary functions of Coenzyme Q10 are bio-energetic and antioxidantAntioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,.... Coenzyme Q10 is an essential co-factor in the cellular production of ATPATP (adenosine triphosphate) molecules are the high-energy molecules with easily broken phosphate bonds that release energy to the energy-requiring processes in the cells. Coenzyme Q10 is essential to the process of ATP production.... More energy. It is also an important fat-soluble antioxidant protecting the cells against oxidative damage caused by harmful free radicalsFree radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... More [Littarru].

Coenzyme Q10 and Longevity

Richard Cardiovascular Health, Diabetes, Kidney disease, Liver disease July 5, 2019July 5, 2019 0 Comment

Metaphorically speaking, CoQ10 supplementation is our umbrella protecting against the risk of chronic degenerative diseases. Studies indicate that 100-300 milligrams of daily Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... supplementation can reduce the risk of cardiovascular disease, type-2 diabetes, kidney disease, and liver disease.

We all want to live longer, with good health and good energy in our senior years. One factor that enhances our chances of living longer and better is our ability to avoid chronic degenerative diseases such as cardiovascular disease, diabetes, kidney disease, and liver disease. Coenzyme Q10 supplements can help.

The rationale for using CoQ10 supplements to enhance our chances for a long and healthy life is based on the role of Coenzyme Q10 in the production of cellular energy. In addition, Coenzyme Q10 has known antioxidantAntioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... and anti-inflammatory effects [Mantle & Hargreaves].

Therapeutic Value of Coenzyme Q10 Treatment for Chronic Heart Failure Patients

Richard Cardiovascular Health June 25, 2019July 1, 2019 0 Comment

Dr. Anne Louise Mortensen, lead author of the European sub-group analysis of the Q-Symbio StudyQ-Symbio is the abbreviated name for the two-year multi-center, randomized, double-blind, placebo-controlled study of Coenzyme Q10 supplements as an adjunct treatment of chronic heart failure patients. The name reflects the focus of the study on the SYMptoms, BIomarker status (BNP), and long-term Outcomes (hospitalizations and mortality) of the supplementation. The data from the Q-Symbio study show that long-term supplementation with... of CoQ10 adjunctive treatment of chronic heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... More patients, pictured together with Dr. and Mrs. William Judy. Dr. Mortensen suggests that one reason for the enhanced effectiveness of the CoQ10 treatment in the European sub-group might be better compliance on the part of the patients. CoQ10 supplements can work only if they are taken as they should be: daily, with meals containing some fat, and in divided doses.

The therapeutic efficacy of Coenzyme Q10 adjunctive treatment of chronic heart failure patients – 3 times 100 milligrams daily for two years – was demonstrated in the original Q-Symbio Study (n = 420) published in the JACC specialty journal Heart FailureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... [Mortensen 2014].

Now, an analysis of just the European portion of the Q-Symbio Study participants (n = 231) has shown that the benefits of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... supplementation were enhanced in the more rigorously guidelines-treated European patients [Mortensen 2019].

Coenzyme Q10 and the Heart Muscle

Richard Cardiovascular Health June 17, 2019June 18, 2019 0 Comment

Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... supplementation is associated with improved left ventricular ejection fractionEjection fraction, sometimes called left ventricular ejection fraction, measures the percentage of blood that the heart pumps out of the left ventricle with each heart contraction. According to the Mayo Clinic guidelines, an ejection fraction above 55% is regarded as normal. An ejection fraction under 50% is regarded as reduced. An ejection fraction below 40% is indicative of heart failure... More in more than a dozen randomized controlled studies.

What does Coenzyme Q10 do for the heart? Quite a lot, it turns out.

Coenzyme Q10 supplementation has been shown in clinical trials to have the following effects with benefit for the heart:

improves left ventricular ejection fraction
improves endothelial function
improves NYHAThe New York Heart Association Functional Classification distinguishes four categories of heart failure according to how much the patients are limited in their physical activity. Category I: No limitation of physical activity. No undue fatigue, palpitation, or shortness of breath. Category II: Slight limitation of physical activity. Comfortable at rest. Fatigue, palpitation, or shortness of breath at ordinary physical activity.... More class
improves contractility
inhibits platelet aggregation
compensates for statin medication

Let’s look more closely at these effects of CoQ10 supplementation.

CoQ10 Supplementation Improves Left Ventricular Ejection Fraction

Ejection fraction is the percentage of the blood that the heart muscle is able to pump out with each heart beat [Cleveland Clinic].

In the healthy heart, the ejection fraction should be in the range from 55% to 70%.
An ejection fraction of 35% to 40% is indicative of mild heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition....
An ejection fraction below 35% indicates moderate to severe heart failure.

A 2013 meta-analysis of 11 heart failure clinical trials showed that CoQ10 supplementation resulted in a pooled mean net increase in the patients’ ejection fraction [Fotino].

Coenzyme Q10 and Metabolic Syndrome

Richard Antioxidant function, Diabetes June 3, 2019June 4, 2019 0 Comment

Metabolic syndromeMetabolic syndrome is the medical term for a cluster of conditions such as excess body fat around the waist, high blood sugar, high blood pressure, high cholesterol or triglyceride levels. Metabolic syndrome is associated with increased risk of diabetes, heart disease, and stroke. Individuals with metabolic syndrome are at higher risk of heart disease, diabetes, and stroke and have, therefore,..., also known as syndrome X, is the name for a cluster of conditions – high blood pressure, high blood sugar, insulin resistance, increased risk of blood clots, abnormal cholesterolCholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... More – that are dangerous themselves and can lead to heart disease and type 2 diabetes. Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... supplementation can improve the associated mitochondrial dysfunctionMitochondrial dysfunction is the loss of efficiency in the process of ATP energy production. As such, mitochondrial dysfunction is a factor in the ageing process and in virtually all chronic diseases including cancer, cardiovascular diseases, chronic fatigue syndrome and fibromyalgia, diabetes and metabolic syndrome, and neurodegenerative diseases. Coenzyme Q10 is an essential component in the mitochondrial production of ATP energy.... More and reduce oxidative stress.

Coenzyme Q10, the essential bio-nutrient, has properties that are germane to the treatment of several of the risk factors associated with the umbrella term “metabolic syndrome” [Casagrande].

These properties include the following:

a bio-energeticsBio-energetics is both the process and the study of the flow and transformation of energy in living beings. Coenzyme Q10 has both a bio-energetics function and an antioxidant function in the body.... More role in the cellular production of ATPATP (adenosine triphosphate) molecules are the high-energy molecules with easily broken phosphate bonds that release energy to the energy-requiring processes in the cells. Coenzyme Q10 is essential to the process of ATP production.... More energy [Casagrande]
a role as a fat-soluble antioxidantAntioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... protecting against oxidative damage by harmful free radicalsFree radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... More to cells and lipids [Casagrande]
an anti-inflammatory effect [Zhai]
a role in the protection and improvement of endothelial function [Gao]

What Factors Reduce Plasma Coenzyme Q10 Levels?

Typically, we expect to find plasma Coenzyme Q10 concentrations ranging from 0.6 to 1.0 micrograms per milliliter in unsupplemented healthy individuals. With daily supplementation, it is possible to raise the plasma Coenzyme Q10 levels above the 2.5 micrograms per milliliter level needed for a therapeutic effect in heart disease and above the 3.5 micrograms per milliliter level needed for a therapeutic effect in neurodegenerative disease [Langsjoen].

WholeFoods Magazine Interview about Coenzyme Q10

Richard Absorption May 21, 2019May 23, 2019 0 Comment

Dr. Richard Passwater’s interviews with Dr. William Judy (pictured here) in the WholeFoods Magazine are fascinating reading about the absorption and clinical effects of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical....

In the February and March 2019 issues of WholeFoods Magazine, Dr. Richard Passwater has published part 1 and part 2 of his interview with Dr. William Judy. These interviews are must reading [Passwater 2019].

The Main Coenzyme Q10 Points in the Dr. Passwater – Dr. Judy Interviews

Dr. Passwater’s interviews with Dr. Judy focus on current issues in CoQ10 research. These issues are of interest to all of us who want to maintain good heart health.

Coenzyme Q10 Molecules are Redox Molecules With Oxidized and Reduced Forms

Coenzyme Q10 molecules are redox molecules with an oxidized form of Coenzyme Q10 called ubiquinoneUbiquinone, the oxidized form of Coenzyme Q10, expressed as Q10 or CoQ10, is absolutely essential for the mitochondrial ATP energy production process. Ubiquinone is the form of Coenzyme Q10 that the body synthesizes, and ubiquinone is the form of Coenzyme Q10 that has been extensively tested for safety, absorption, and efficacy in clinical trials...., an intermediate partially reduced form called ubisemiquinonesee redox molecule., and a reduced form called ubiquinol. The ubiquinone and ubiquinol forms are both used in Coenzyme Q10 supplements. Both forms are active and important forms.

Coenzyme Q10: An Insider’s Guide by Dr. William V. Judy

Richard Bioavailability and Safety, Cardiovascular Health April 29, 2019April 30, 2019 0 Comment

Dr. William V. Judy, the founder and president of the SIBR Research Institute, was one of the first researchers to raise questions about misleading marketing claims for Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... products. Now he has written a book to share his knowledge of the relevant clinical research into the absorption, bio-availability, efficacy, and safety of CoQ10 supplements.

Coenzyme Q10 is, literally, the substance that powers life. It is an essential bio-nutrient required for the cellular process of ATPATP (adenosine triphosphate) molecules are the high-energy molecules with easily broken phosphate bonds that release energy to the energy-requiring processes in the cells. Coenzyme Q10 is essential to the process of ATP production.... More energy production. It is also an important fat-soluble antioxidantAntioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,.... Oral CoQ10 supplementation is positively associated with the reduction of blood bio-markers for oxidative stress and inflammationInflammation is an immune system response to an injury to cells or tissues. It is the body’s attempt to defend against invaders such as bacteria andviruses and to mend the damage done by invaders. Typically, inflammation manifests itself in the form of fever and swelling, in the swarming of white blood cells and the release of cytokines to fight against....

Now available from amazon.com is Dr. William Judy’s new book entitled Coenzyme Q10: An Insider’s Guide.

A simple search for the words Judy and Q10 will find the book on Amazon.

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