Coenzyme Q10 Supplementation for Fibromyalgia Patients

Fibromyalgia is a common chronic pain condition without a known cause and without a reliable, effective medical treatment. It has several signs and symptoms in common with chronic fatigue syndrome: fatigue, pain, weakness, a feeling of discomfort in the body, a sense of unease and/or anxiety and depression.

Woman suffering from fibromyalgia
Treatment of fibromyalgia generally involves physiotherapy, anti-convulsants, and antidepressant therapy. Adequate intake of Coenzyme Q10, magnesium, selenium, vitamin D, and vitamin B12 may be beneficial.

Mitochondrial dysfunction, oxidative stress, and inflammation have been associated with fibromyalgia.

CoQ10 supplementation may restore an underlying deficit in CoQ10 status, which has been associated with fibromyalgia, and may improve the fibromyalgia patient’s outlook by:

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The Instability of Ubiquinol Supplements – Lab Studies

At SIBR Research, we have long been concerned about misleading claims for ubiquinol supplements on the Web. It seems that there is a lack of understanding of the processes influencing the absorption and subsequent metabolism of ubiquinol. Moreover, this misunderstanding seems to have been exacerbated by some manufacturers’ incorrect claims regarding the bioavailability of their ubiquinol supplements [Mantle & Dybring 2020].

Dr William V Judy
SIBR Research studies show that the ubiquinol in supplements is very likely to be converted to ubiquinone in the small intestines, to be absorbed as ubiquinone, and then to be converted back to ubiquinol in the lymph.

Basic Information about Ubiquinone and Ubiquinol

  • Ubiquinol is the reduced form of Coenzyme Q10; it is the antioxidant form of Coenzyme Q10.
  • Ubiquinone is the oxidized form of Coenzyme Q10. It is essential for the process of ATP energy generation.

Note: Both forms of Coenzyme Q10 are bio-active forms.

Ubiquinone More Stable than Ubiquinol in Supplements

Ubiquinol molecules are electron donors. Thus, they are inherently unstable. They are constantly looking to give up two electrons. It is this property that first made us wonder whether the ubiquinol in supplements actually gets absorbed as ubiquinol or gets converted to ubiquinone before being absorbed.

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Low Coenzyme Q10 in Hereditary Hemochromatosis

In a 2021 study, patients with hereditary hemochromatosis were observed to have significantly lower plasma concentrations of Coenzyme Q10 [Martinefski 2021].

Jan Aaseth
Professor Jan Aaseth has published medical journal articles about the treatment options for iron overload: phlebotomy and chelation. Phlebotomy is the initial treatment of choice in hemochromatosis.

Hereditary hemochromatosis is a genetic disorder that causes the body to build up too much iron in various organs including the heart and liver. The iron overload is toxic and can damage tissues and organs and lead to liver disease [CDC 2020].

The CDC reports that one-third of one percent of non-Hispanic Caucasians in the US has hereditary hemochromatosis. The rates are somewhat lower in other races and ethnic groups. It is more common for men to develop complications, often at an earlier age. Approximately one in ten men with hereditary hemochromatosis will develop severe liver disease.

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Coenzyme Q10 for Traumatic Injury Patients in the Intensive Care Unit

The administration of supplemental Coenzyme Q10 in addition to conventional medical treatment has beneficial effects on patients with traumatic injury and has no observed adverse effects.

Intubation
Prolonged mechanical ventilation of patients in intensive care units can have adverse effects. In this study, administration of 400 milligrams of Coenzyme Q10 daily significantly reduced the length of stay in the intensive care unit and the duration of the mechanical ventilation.

This is the conclusion from a clinical trial that enrolled patients who had been admitted to the intensive care unit [Hasanloei 2021].

The problem: trauma

-Traumatic injury is not uncommon: nearly one-third of the patients admitted to a typical intensive care unit in pre-Covid 19 days were admitted with traumatic injuries of one type or another.

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Coenzyme Q10 and NADH in Chronic Fatigue Syndrome

Both Coenzyme Q10 and NADH blood levels have been shown to be sub-optimal in patients diagnosed with chronic fatigue syndrome [Castro-Marrero 2013; Maes 2009].

Dr. William V. Judy
Dr. Judy regards mitochondrial dysfunction, reduced immune function, and increased oxidative stress as biological explanations for the inverse association between CoQ10 and NADH status and the severity of chronic fatigue syndrome.

In chronic fatigue syndrome, patients have the following symptoms:

  • fatigue that persists even after rest and sleep
  • generalized chronic pain
  • lack of motivation for physical and mental exertion
  • disruptions in concentration and memory
  • changes in sleep patterns and duration

Chronic fatigue syndrome is a severe disabling condition without a good prognosis. There is no universally recognized treatment mode.

CoQ10 and NADH Combined Supplementation in Chronic Fatigue Syndrome

Now a randomized controlled trial published in 2021 shows that supplementation of chronic fatigue syndrome patients with 200 mg of Coenzyme Q10 and 20 mg of NADH daily for 12 weeks has statistically significant health benefits:

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Coenzyme Q10 for Pets and Farm Animals and Race Horses

Back in November of 2020, q10facts.com ran a story about the experimental use of CoQ10 supplementation in dogs, Cavalier King Charles Spaniels with mitral valve disease, to be precise. The study results showed that 2 times 100 mg daily had significantly raised the animals’ blood CoQ10 concentrations [Christiansen 2020].

Dr. William Judy
Guest author Dr. William Judy, President of SIBR Research and Coenzyme Q10 researcher for over 40 years. Here, lecturing at an International Coenzyme Q10 Association conference in Bologna, Italy.

Coenzyme Q10 and Danny the Sheep

Just recently, I received an email about the CoQ10 experiences of a sheep farmer in the North of England who writes as follows:

Danny is a three-year-old sheep. Danny developed severe swelling on both sides of his abdomen, he had difficulty standing, and he lost interest in his feed. He was seen by the local vet, who diagnosed heart failure and said Danny was going to die within the next week or so. There is no veterinary treatment for sheep with heart failure.

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Covid-19 and Coenzyme Q10 and Selenium

In the UK, biochemist Iain R. Hargreaves and medical doctor David Mantle have written that the initial immune system response to the Covid-19 virus and the subsequent resolution of the resulting inflammation may well be dependent upon nutritional status, including micronutrient status. Accordingly, they have investigated the relationship between the status of two micronutrients, Coenzyme Q10 and selenium, and the effect on oxidative stress and inflammation [Hargreaves & Mantle 2021].

Covid-19 test
In a 2021 review article, Hargreaves and Mantle write that adequate intakes of both Coenzyme Q10 and selenium are necessary for optimal immune system defense against Covid-19 infections.

They conclude that optimal status of both Coenzyme Q10 and selenium may be one aspect of an effective program to prevent and treat Covid-19 infections [Hargreaves & Mantle 2021]. The important thing in dealing with Covid-19 infections is to achieve and maintain a balance in the immune response against the virus without causing a cytokine storm as the cytokine storm is the cause of lung injury and respiratory distress in severe cases.

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Coenzyme Q10 Protects Against Oxidative Stress and Inflammation

Herewith summaries of 2020-2021 meta-analyses of randomized controlled trials of Coenzyme Q10 supplementation for protection against oxidative stress and chronic inflammation. Note: A meta-analysis is a specific procedure for the pooling and evaluating of data from many individual studies for the purpose of getting more precise results.

CoQ10 and Protection Against Oxidative Stress

Hajiluian et al. investigated the antioxidant effect of CoQ10 supplementation in an analysis of 17 randomized controlled trials enrolling 972 participants. The aggregated data showed that CoQ10 supplementation is associated significantly with increased serum total antioxidant capacity, with increased superoxide dismutase levels, and with decreased malondialdehyde levels compared to the placebo group. The researchers concluded that CoQ10 supplementation improves antioxidant protection against oxidative damage caused by reactive oxygen species.

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Coenzyme Q10 and Immune Function

Coenzyme Q10 supplementation is especially well-regarded for the prevention and adjunctive treatment of heart failure [Mortensen 2014; Mortensen 2019].

Insider's Guide to Coenzyme Q10
The best guide to clinical studies of Coenzyme Q10 supplementation is Dr. William Judy’s Insider’s Guide to Coenzyme Q10, available from amazon.com. ISBN: 978-87-7776-186-7.

Administration of Coenzyme Q10 is also recommended for the treatment of statin-associated muscle symptoms [Raizner & Quiñones 2021].

Randomized controlled clinical studies have also shown that CoQ10 supplementation can help to prevent or treat such disorders as diabetes [Mantle 2017], non-alcoholic fatty liver disease [Mantle 2020], chronic kidney disease [Hargreaves 2019], and migraine [Sazali 2021].

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Coenzyme Q10 and Male Infertility

There is more and more evidence that Coenzyme Q10 plays a physiological role in the maintenance of semen quality [Alahmar 2021]:

  • Higher CoQ10 concentrations in seminal plasma correlate directly with elevated semen parameters such as sperm motility and sperm count.
  • Seminal CoQ10 concentrations are sub-optimal in male infertility conditions.
Pregnant woman
Infertility affects an estimated 15% of couples worldwide. Male infertility is a factor in about 50% of cases. The causes of male infertility are poorly understood, but there is evidence that oxidative stress is related to poor seminal fluid quality. Coenzyme Q10 is a powerful antioxidant, reducing levels of oxidative stress.

In a 2021 review article, Alahmar et al. [2021] summarize the research into CoQ10’s role in the regulation of male reproductive function:

  • restores semen parameters in male infertility patients
  • reduces the blood levels of biomarkers for oxidative stress
  • improves pregnancy and assisted reproductive technology outcomes
  • reduces sperm DNA fragmentation

CoQ10 Effects on Sperm Parameters

Alahmar et al. [2021] have reviewed several clinical trials of the CoQ10 supplementation of patients with male infertility. Overall, the outcomes of these studies show the following beneficial effects:

  • increased concentrations of Coenzyme Q10 in the semen and in spermatozoa
  • enhanced sperm parameters: sperm concentration, motility, and morphology
  • improved oxidative stress bio-markers and increased protection against free radical-induced sperm damage

CoQ10 Effects on Sperm DNA Fragmentation

Current evidence shows that Sperm DNA Fragmentation plays a crucial role in male infertility. Oxidative stress may be the key mechanism causing the sperm DNA fragmentation. An excess of harmful free radicals may be causing kinks and breaks in sperm DNA.

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