Fatigue. In many disorders, patients experience fatigue, even extreme fatigue, e.g., heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately.  In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... More patients, chronic fatigue syndromeChronic fatigue syndrome (CFS) is a complicated disorder with an unknown cause.  CFS is characterized by persistent fatigue that does not improve with rest and that cannot be explained by any identifiable medical condition. CFS is also known as myalgic encephalomyelitis (ME) and systemic exertion intolerance disease (SEID).  It is sometimes abbreviated ME/CFS. CFS patients typically have low levels of... More and fibromyalgiaFibromyalgia is characterized by widespread muscle and bone pain.  The pain is accompanied by fatigue, sleep, memory problems, and mood issues. Fibromyalgia seems to amplify the brain's processing of painful signals and sensations. Whereas the emphasis in chronic fatigue syndrome is on the persistent fatigue, the emphasis in fibromyalgia is on the widespread pain. Some studies have shown that CoQ10... More patients, multiple sclerosis patients, post-treatment Lyme disease syndrome patients, etc.

The chronic fatigue may well be associated with cellular energy depletion and impaired mitochondrial function [Mantle 2022].

• Research studies have implicated mitochondrial dysfunctionMitochondrial dysfunction is the loss of efficiency in the process of ATP energy production.  As such, mitochondrial dysfunction is a factor in the ageing process and in virtually all chronic diseases including cancer, cardiovascular diseases, chronic fatigue syndrome and fibromyalgia, diabetes and metabolic syndrome, and neurodegenerative diseases. Coenzyme Q10 is an essential component in the mitochondrial production of ATP energy. More in the development of chronic fatigue syndromeChronic fatigue syndrome (CFS) is a complicated disorder with an unknown cause.  CFS is characterized by persistent fatigue that does not improve with rest and that cannot be explained by any identifiable medical condition. CFS is also known as myalgic encephalomyelitis (ME) and systemic exertion intolerance disease (SEID).  It is sometimes abbreviated ME/CFS. CFS patients typically have low levels of... More and fibromyalgiaFibromyalgia is characterized by widespread muscle and bone pain.  The pain is accompanied by fatigue, sleep, memory problems, and mood issues. Fibromyalgia seems to amplify the brain's processing of painful signals and sensations. Whereas the emphasis in chronic fatigue syndrome is on the persistent fatigue, the emphasis in fibromyalgia is on the widespread pain. Some studies have shown that CoQ10... More and in the resulting fatigue [Mantle 2022].
• The outcomes of randomized controlled clinical trials have shown that CoQ10 supplementation significantly improves symptoms in chronic fatigue syndromeChronic fatigue syndrome (CFS) is a complicated disorder with an unknown cause.  CFS is characterized by persistent fatigue that does not improve with rest and that cannot be explained by any identifiable medical condition. CFS is also known as myalgic encephalomyelitis (ME) and systemic exertion intolerance disease (SEID).  It is sometimes abbreviated ME/CFS. CFS patients typically have low levels of... More and fibromyalgiaFibromyalgia is characterized by widespread muscle and bone pain.  The pain is accompanied by fatigue, sleep, memory problems, and mood issues. Fibromyalgia seems to amplify the brain's processing of painful signals and sensations. Whereas the emphasis in chronic fatigue syndrome is on the persistent fatigue, the emphasis in fibromyalgia is on the widespread pain. Some studies have shown that CoQ10... More patients [Mantle 2022].
• A 2019 systematic review of CoQ10 supplementation studies has shown significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant.   More benefits of CoQ10 supplementation on fatigue following exercise, statin intake, the development of multiple sclerosis, and the development of end-stage heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately.  In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... More [Mehrabani 2019].
• Supplemental CoQ10 has been shown to significantly improve plasma and skeletal muscle CoQ10 levels, exercise tolerance, and exercise recovery time in chronic fatigue patients. The response is not rapid. It takes months of supplementation to allow mitochondriaThe mitochondria are the bean-shaped organelles in the cells. They are the key organelles with responsibility for the production of ATP energy molecules. More regeneration and the improvement in exercise tolerance. If the supplementation of CoQ10 is stopped, then the chronic fatigue will slowly return [Judy 2018a, 2018b].

Coenzyme Q10, Inflammation, and Fatigue

Mantle et al [2022] make the point that that inflammationInflammation is an immune system response to an injury to cells or tissues. It is the body’s attempt to defend against invaders such as bacteria andviruses and to mend the damage done by invaders. Typically, inflammation manifests itself in the form of fever and swelling, in the swarming of white blood cells and the release of cytokines to fight against... More, which involves the release of pro-inflammatory cytokines, is not a wholly negative process in the body. InflammationInflammation is an immune system response to an injury to cells or tissues. It is the body’s attempt to defend against invaders such as bacteria andviruses and to mend the damage done by invaders. Typically, inflammation manifests itself in the form of fever and swelling, in the swarming of white blood cells and the release of cytokines to fight against... More is the body’s normal response to infection or injury; it is essential for tissue healing.