Coenzyme Q10’s Anti-Inflammatory Effects

Professor Urban Alehagen
A well-designed randomized controlled clinical trial, the KiSel-10 study, has shown that a combined daily supplementation of senior citizens with Coenzyme Q10 and high-selenium yeast can reduce cardiovascular mortality by over 50%. Professor Urban Alehagen thinks that a special interrelationship between the two supplements has resulted in less oxidative stress, less low-grade chronic inflammation, and less fibrosis in the senior citizens taking the active treatment as opposed to the placebo treatment.

Two independent meta-analyses of the available research literature have shown that Coenzyme Q10 supplementation is associated with healthy levels of bio-markers for chronic systemic inflammation [Zhai 2017; Fan 2017].

  • Chronic inflammation – a persistent low-grade inflammation – can have deleterious effects throughout the body. Over time, it can result in tissue damage.
  • Chronic inflammation is something different from acute inflammation, which is the immune system’s short-term response to an injury or an infection.
  • Chronic low-grade inflammation has been linked to increased risk of heart disease, stroke, diabetes, and metabolic disorders [Zhai 2017].
  • The extent of chronic low-grade inflammation can be measured by testing for the blood levels of known bio-markers for inflammation [Zhai 2017].

Coenzyme Q10 Effect on Tumor Necrosis Factor-Alpha

Zhai et al analyzed nine randomized controlled trials enrolling 428 study participants.  The results of their analysis showed that CoQ10 supplementation significantly improved the serum concentration of Coenzyme Q10 by 1.17 micrograms per milliliter on average compared to placebo treatment [Zhai].

read more

Coenzyme Q10 Adjunctive Treatment for Heart Failure

Dr. William Judy
Dr. William Judy has been doing clinical research with CoQ10 treatment of heart failure patients for 40 years. The heart muscle tissue of heart failure patients is known to be deficient in Coenzyme Q10. Three times 100 milligrams of Coenzyme Q10 per day added to conventional heart failure medicine improves the patients’ quality of life and chances of survival as compared to placebo together with conventional treatment.

Heart failure is what happens when the heart is no longer able to pump out blood as strongly as it should.  It occurs when the heart is too weak or too stiff to fill up with blood and pump out blood efficiently. It is characterized by reduced functional capacity and reduced quality of life:

  • Reduced ability to exercise and do work
  • Shortness of breath
  • Swelling in the lower extremities
  • Weakness and fatigue from exertion

Heart failure is one of the most costly medical conditions in terms of complications and hospitalizations.  The costs of medical care for heart failure patients is expected to rise from $30 billion per year in 2018 to nearly $70 million by 2030 [Bhatt & Butler 2018].

read more

Top Ten Coenzyme Q10 and Heart Disease Studies

The best thing about Coenzyme Q10 adjuvant treatment of heart disease is that the CoQ10 treatment is a positive treatment. It does not block or reduce any neurohormonal activities in the body; instead, it enhances mitochondrial function in the process of cellular ATP energy production. And it provided antioxidant defense of the heart muscle cells.  Pictured here: Dr. Svend Aage Mortensen, lead researcher on the Q-Symbio Study.

We have over 30 years of evidence from published clinical trials showing that the ubiquinone form of Coenzyme Q10 supplementation is safe, well-tolerated, and effective as an adjuvant treatment for heart disease patients. The ubiquinone form of Coenzyme Q10 is also stable and affordable.  

It is important to remember that Coenzyme Q10 supplements vary considerably in their absorption and bio-availability.  A recent comparison study has shown that the formulation of the supplement – the composition of the carrier oils and the heating/cooling process – is more important for absorption and bio-availability than the form of the supplement (ubiquinone or ubiquinol) is [Lopez-Lluch 2019].

read more

Coenzyme Q10 Meta-analyses Summarized

Dr. William V. Judy, founder and president of the SIBR Research Institute, has written about the clinical aspects of CoQ10 supplementation in his 2018 book entitled Coenzyme Q10: An Insider’s Guide. The book is highly recommended.  It is available from amazon.com.

Coenzyme Q10 is a bio-nutrient essential to the process of ATP energy generation in the cells.  It is also an important fat-soluble antioxidant.  It helps to maintain proper endothelial function  regulating vascular contraction and relaxation and regulating the enzymes that control blood clotting, immune function, and platelet adhesion.  It has anti-inflammatory properties [Littarru 2010].  Our primary source of Coenzyme Q10 is our bodies’ bio-synthesis of the substance.  Our food contributes considerably less Coenzyme Q10.

read more

Coenzyme Q10 and Fibrosis and Ageing

Dr. Urban Alehagen, professor emeritus, Linköping University in Sweden, is the lead researcher on the KiSel-10 study of the effects of combined Coenzyme Q10 and selenium supplementation on the heart health of senior citizens. Senior citizens who took CoQ10 and high-selenium yeast supplements for four years had significantly better heart function and significantly reduced heart mortality compared to senior citizens who took matching placebos. One possible explanation is that there was significantly less fibrogenic activity in the treatment group than in the placebo group and that the reduced levels of fibrosis are related to the improved heart function and reduced cardiovascular mortality in the treatment group.

Daily supplementation with the ubiquinone form of Coenzyme Q10 and selenium-enriched yeast has significant health benefits for senior citizens:

  • The combination of the two supplements reduces the levels of bio-markers for fibrosis in senior citizens [Alehagen 2018].
  • The combination of the two supplements improves cardiovascular function and reduces the risk of cardiovascular mortality [Alehagen 2013].
  • The combination of the two supplements provides a means of correcting a dietary shortage to which senior citizens may be subject [Hargreaves & Mantle].

Fibrosis and the Ageing Process

Fibrosis is the bio-medical term for the formation of fibrous connective tissue, much of which is collagen.

  • Fibrosis is a normal process for wound healing and tissue repair.
  • In senior citizens, there is a greater risk of uncontrolled continuation of the formation of fibrous connective tissue, resulting in tissue scarring and loss of function in organs such as the heart, lungs, liver, and kidneys [Hargreaves & Mantle].
  • Progressive fibrosis and loss of function in vital organs is a known symptom of ageing [Hargreaves & Mantle].
  • Organ fibrosis has been estimated to be a factor in up to 50% of all-cause human deaths [Hargreaves & Mantle].
  • Effective treatments for fibrosis in senior citizens are not available at present [Hargreaves & Mantle].

Coenzyme Q10 and Senior Citizens

Coenzyme Q10 has important biological roles in humans:

  • Coenzyme Q10 is an essential co-factor in the cellular process of ATP energy generation [Belardinelli].
  • Coenzyme Q10 is an important fat-soluble antioxidant, neutralizing the harmful effects of free radicals in lipid environments and reducing the extent of oxidative stress [Belardinelli].
  • Coenzyme Q10 has a beneficial effect on the endothelial cells that regulate the contraction and relaxation of the blood vessels and regulate such processes as blood clotting, immune function, and platelet adhesion [Belardinelli].
  • Coenzyme Q10 reduces the blood levels of bio-markers for inflammation, indicating that Coenzyme Q10 may have anti-inflammatory properties [Hargreaves & Mantle].

Decreasing CoQ10 Bio-Synthesis with Increasing Age

The major source of Coenzyme Q10 in humans is the endogenous bio-synthesis of the substance.

  • Once we humans reach our 20s, most of us begin to synthesize less Coenzyme Q10 as we get older [Hargreaves & Mantle].
  • It is impossible to make up the ageing-related loss of bio-synthesized Coenzyme Q10 by eating more food or by eating more wisely [Hargreaves & Mantle].
  • Daily supplementation is necessary [Hargreaves & Mantle].
  • Not all CoQ10 supplements are equally well formulated.  The formulation of the CoQ10 supplement plays a vital role in CoQ10 absorption and bio-availability [Lopez-Lluch].

Cardiovascular Fibrosis and Senior Citizens

Post-mortem analysis has revealed that, in the normal ageing process, the collagen content providing structural support for heart muscle’s contractile cells increases approximately 50% from the third decade to the seventh decade of life [Hargreaves & Mantle].

read more

Coenzyme Q10 and Longevity

Metaphorically speaking, CoQ10 supplementation is our umbrella protecting against the risk of chronic degenerative diseases. Studies indicate that 100-300 milligrams of daily Coenzyme Q10 supplementation can reduce the risk of cardiovascular disease, type-2 diabetes, kidney disease, and liver disease.

We all want to live longer, with good health and good energy in our senior years.  One factor that enhances our chances of living longer and better is our ability to avoid chronic degenerative diseases such as cardiovascular disease, diabetes, kidney disease, and liver disease.  Coenzyme Q10 supplements can help.

The rationale for using CoQ10 supplements to enhance our chances for a long and healthy life is based on the role of Coenzyme Q10 in the production of cellular energy.  In addition, Coenzyme Q10 has known antioxidant and anti-inflammatory effects [Mantle & Hargreaves].

read more

Therapeutic Value of Coenzyme Q10 Treatment for Chronic Heart Failure Patients

Dr. Anne Louise Mortensen, lead author of the European sub-group analysis of the Q-Symbio Study of CoQ10 adjunctive treatment of chronic heart failure patients, pictured together with Dr. and Mrs. William Judy. Dr. Mortensen suggests that one reason for the enhanced effectiveness of the CoQ10 treatment in the European sub-group might be better compliance on the part of the patients. CoQ10 supplements can work only if they are taken as they should be: daily, with meals containing some fat, and in divided doses.

The therapeutic efficacy of Coenzyme Q10 adjunctive treatment of chronic heart failure patients – 3 times 100 milligrams daily for two years – was demonstrated in the original Q-Symbio Study (n = 420) published in the JACC specialty journal Heart Failure [Mortensen 2014].

Now, an analysis of just the European portion of the Q-Symbio Study participants (n = 231) has shown that the benefits of Coenzyme Q10 supplementation were enhanced in the more rigorously guidelines-treated European patients [Mortensen 2019].

read more

Coenzyme Q10 and the Heart Muscle

Coenzyme Q10 supplementation is associated with improved left ventricular ejection fraction in more than a dozen randomized controlled studies.

What does Coenzyme Q10 do for the heart?  Quite a lot, it turns out.

Coenzyme Q10 supplementation has been shown in clinical trials to have the following effects with benefit for the heart:

  • improves left ventricular ejection fraction
  • improves endothelial function
  • improves NYHA class
  • improves contractility
  • inhibits platelet aggregation
  • compensates for statin medication

Let’s look more closely at these effects of CoQ10 supplementation.

CoQ10 Supplementation Improves Left Ventricular Ejection Fraction

Ejection fraction is the percentage of the blood that the heart muscle is able to pump out with each heart beat [Cleveland Clinic].

  • In the healthy heart, the ejection fraction should be in the range from 55% to 70%.
  • An ejection fraction of 35% to 40% is indicative of mild heart failure.
  • An ejection fraction below 35% indicates moderate to severe heart failure.

A 2013 meta-analysis of 11 heart failure clinical trials showed that CoQ10 supplementation resulted in a pooled mean net increase in the patients’ ejection fraction [Fotino].

read more

Coenzyme Q10: An Insider’s Guide by Dr. William V. Judy

Dr. William V. Judy, the founder and president of the SIBR Research Institute, was one of the first researchers to raise questions about misleading marketing claims for Coenzyme Q10 products. Now he has written a book to share his knowledge of the relevant clinical research into the absorption, bio-availability, efficacy, and safety of CoQ10 supplements.

Coenzyme Q10 is, literally, the substance that powers life.  It is an essential bio-nutrient required for the cellular process of ATP energy production.  It is also an important fat-soluble antioxidant.  Oral CoQ10 supplementation is positively associated with the reduction of blood bio-markers for oxidative stress and inflammation.

Now available from amazon.com is Dr. William Judy’s new book entitled Coenzyme Q10: An Insider’s Guide. 

A simple search for the words Judy and Q10 will find the book on Amazon.

read more

Coenzyme Q10 supplementation and coronary artery disease

Elevated total cholesterol levels and/or elevated low-density lipoprotein (LDL) cholesterol levels are associated with increased risk of coronary artery disease, which is the most common form of heart disease. Now, a meta-analysis shows that CoQ10 supplementation significantly improves total cholesterol and HDL-cholesterol in coronary artery disease patients.

Coenzyme Q10 adjuvant treatment of heart failure patients significantly improves the symptoms and survival of chronic heart failure patients [Mortensen; Morisco; Munkholm].

How does it look with Coenzyme Q10 supplementation and coronary artery disease?

Coronary artery disease is caused by hardening and narrowing of the coronary arteries that bring blood to the heart muscle? Coronary artery disease is also known as ischemic heart disease, which is heart disease characterized by reduced flow of blood containing oxygen to the heart muscle.

read more