CoQ10 Supplementation for MS Patients

Wheelchair in the park
MS patients may consider using a wheelchair to conserve strength and reduce fatigue or to prevent falls. Clinical trial evidence shows that high doses of CoQ10 daily can reduce the feeling of fatigue.

Daily supplementation of 60 multiple sclerosis patients with 200 milligrams of Coenzyme Q10 for three months showed beneficial clinical outcomes for the multiple sclerosis patients [Moccia 2019]:

The open-label crossover design study also had the following biological benefits [Moccia 2019]:

  • decreased the intracellular production of harmful free radicals
  • reduced the extent of oxidative damage in the peripheral blood
  • improved the anti-inflammatory environment in the peripheral blood
  • attenuated the extent of pro-inflammatory cytokines in the peripheral blood

CoQ10 and MS and Depression and Fatigue

In a randomized, double-blinded, placebo-controlled trial, daily CoQ10 supplementation of multiple sclerosis patients with 500 mg/day for 12 weeks was associated the following health benefits [Sanoobar 2016]:

  • a significant decrease in fatigue symptoms quantified using the fatigue severity scale
  • a significant improvement of depression symptoms as shown in Beck Depression Inventory scores

CoQ10 and MS and Inflammation and Oxidative Stress

In the same study, supplementation with 500 milligrams per day for 12 weeks significantly reduced the blood levels of known bio-markers for systemic inflammation compared to the placebo group [Sanoobar 2015]:

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Coenzyme Q10 and MS (multiple sclerosis)

What do we know about MS?  It is a disabling disease of the brain and spinal cord.  It is two to three times more common in women than in men. Depending on the nerve damage, people with MS may lose the ability to walk independently.  There is no cure. Fatigue and depression are common symptoms. Now, a study shows that large daily doses of Coenzyme Q10 can reduce the extent of depression and fatigue in MS patients.

Pilot study news:  A new study shows that Coenzyme Q10 supplementation reduces depression and fatigue in multiple sclerosis patients.  This is good news indeed.  Moreover, these are research results that make sense.

We know that Coenzyme Q10 supplementation improves the symptoms of both chronic fatigue syndrome patients [Castro-Marrero 2016] and fibromyalgia patients [Cordero 2013].  At least one study has shown that Coenzyme Q10 supplementation improves the symptoms of depression [Forester 2012].

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