CoQ10 Supplementation for MS Patients

Richard Morrill Multiple sclerosis December 25, 2020February 9, 2022 0 Comment

Wheelchair in the park — MS patients may consider using a wheelchair to conserve strength and reduce fatigue or to prevent falls. Clinical trialClinical trials are research studies in which various treatments, interventions, or tests are investigated for their safety and efficacy when used to detect, prevent, or treat diseases and medical conditions in patients and healthy volunteers. The gold standard for clinical trials are randomized, double-blind, placebo-controlled studies. More evidence shows that high doses of CoQ10 daily can reduce the feeling of fatigue.

Daily supplementation of 60 multiple sclerosis patients with 200 milligrams of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both synthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More for three months showed beneficial clinical outcomes for the multiple sclerosis patients [Moccia 2019]:

fewer symptoms of depression
less disability, fatigue, and pain

The open-label crossover design study also had the following biological benefits [Moccia 2019]:

decreased the intracellular production of harmful free radicalsFree radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... More
reduced the extent of oxidative damage in the peripheral blood
improved the anti-inflammatory environment in the peripheral blood
attenuated the extent of pro-inflammatory cytokines in the peripheral blood

CoQ10 and MS and Depression and Fatigue

In a randomized, double-blinded, placebo-controlled trial, daily CoQ10 supplementation of multiple sclerosis patients with 500 mg/day for 12 weeks was associated the following health benefits [Sanoobar 2016]:

a significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. More decrease in fatigue symptoms quantified using the fatigue severity scale
a significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. More improvement of depression symptoms as shown in Beck Depression Inventory scores

CoQ10 and MS and Inflammation and Oxidative Stress

In the same study, supplementation with 500 milligrams per day for 12 weeks significantly reduced the blood levels of known bio-markers for systemic inflammationInflammation is an immune system response to an injury to cells or tissues. It is the body’s attempt to defend against invaders such as bacteria andviruses and to mend the damage done by invaders. Typically, inflammation manifests itself in the form of fever and swelling, in the swarming of white blood cells and the release of cytokines to fight against... More compared to the placebo group [Sanoobar 2015]:

Coenzyme Q10 and MS (multiple sclerosis)

Richard Morrill Immune system, Multiple sclerosis October 6, 2017May 4, 2022 0 Comment

What do we know about MS? It is a disabling disease of the brain and spinal cord. It is two to three times more common in women than in men. Depending on the nerve damage, people with MS may lose the ability to walk independently. There is no cure. Fatigue and depression are common symptoms. Now, a study shows that large daily doses of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both synthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More can reduce the extent of depression and fatigue in MS patients.

Pilot study news: A new study shows that Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both synthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplementation reduces depression and fatigue in multiple sclerosis patients. This is good news indeed. Moreover, these are research results that make sense.

We know that Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both synthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplementation improves the symptoms of both chronic fatigue syndromeChronic fatigue syndrome (CFS) is a complicated disorder with an unknown cause. CFS is characterized by persistent fatigue that does not improve with rest and that cannot be explained by any identifiable medical condition. CFS is also known as myalgic encephalomyelitis (ME) and systemic exertion intolerance disease (SEID). It is sometimes abbreviated ME/CFS. CFS patients typically have low levels of... More patients [Castro-Marrero 2016] and fibromyalgiaFibromyalgia is characterized by widespread muscle and bone pain. The pain is accompanied by fatigue, sleep, memory problems, and mood issues. Fibromyalgia seems to amplify the brain's processing of painful signals and sensations. Whereas the emphasis in chronic fatigue syndrome is on the persistent fatigue, the emphasis in fibromyalgia is on the widespread pain. Some studies have shown that CoQ10... More patients [Cordero 2013]. At least one study has shown that Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both synthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplementation improves the symptoms of depression [Forester 2012].