
Daily supplementation of 60 multiple sclerosis patients with 200 milligrams of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both synthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More for three months showed beneficial clinical outcomes for the multiple sclerosis patients [Moccia 2019]:
- fewer symptoms of depression
- less disability, fatigue, and pain
The open-label crossover design study also had the following biological benefits [Moccia 2019]:
- decreased the intracellular production of harmful free radicalsFree radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... More
- reduced the extent of oxidative damage in the peripheral blood
- improved the anti-inflammatory environment in the peripheral blood
- attenuated the extent of pro-inflammatory cytokines in the peripheral blood
CoQ10 and MS and Depression and Fatigue
In a randomized, double-blinded, placebo-controlled trial, daily CoQ10 supplementation of multiple sclerosis patients with 500 mg/day for 12 weeks was associated the following health benefits [Sanoobar 2016]:
- a significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. More decrease in fatigue symptoms quantified using the fatigue severity scale
- a significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. More improvement of depression symptoms as shown in Beck Depression Inventory scores
CoQ10 and MS and Inflammation and Oxidative Stress
In the same study, supplementation with 500 milligrams per day for 12 weeks significantly reduced the blood levels of known bio-markers for systemic inflammationInflammation is an immune system response to an injury to cells or tissues. It is the body’s attempt to defend against invaders such as bacteria andviruses and to mend the damage done by invaders. Typically, inflammation manifests itself in the form of fever and swelling, in the swarming of white blood cells and the release of cytokines to fight against... More compared to the placebo group [Sanoobar 2015]: