Coenzyme Q10 and Immune Function

Coenzyme Q10 supplementation, already especially well-regarded for the prevention and adjunctive treatment of heart failure, has biological importance for immune system function [Mortensen 2014; Mortensen 2019].

Insider's Guide to Coenzyme Q10
The best guide to clinical studies of Coenzyme Q10 supplementation is Dr. William Judy’s Insider’s Guide to Coenzyme Q10, available from ISBN: 978-87-7776-186-7.

Administration of Coenzyme Q10 is also recommended for the treatment of statin-associated muscle symptoms [Raizner & Quiñones 2021].

Randomized controlled clinical studies have also shown that CoQ10 supplementation can help to prevent or treat such disorders as diabetes [Mantle 2017], non-alcoholic fatty liver disease [Mantle 2020], chronic kidney disease [Hargreaves 2019], and migraine [Sazali 2021].

Read more

Coenzyme Q10 and MS (multiple sclerosis)

What do we know about MS?  It is a disabling disease of the brain and spinal cord.  It is two to three times more common in women than in men. Depending on the nerve damage, people with MS may lose the ability to walk independently.  There is no cure. Fatigue and depression are common symptoms. Now, a study shows that large daily doses of Coenzyme Q10 can reduce the extent of depression and fatigue in MS patients.

Pilot study news:  A new study shows that Coenzyme Q10 supplementation reduces depression and fatigue in multiple sclerosis patients.  This is good news indeed.  Moreover, these are research results that make sense.

We know that Coenzyme Q10 supplementation improves the symptoms of both chronic fatigue syndrome patients [Castro-Marrero 2016] and fibromyalgia patients [Cordero 2013].  At least one study has shown that Coenzyme Q10 supplementation improves the symptoms of depression [Forester 2012].

Read more

Coenzyme Q10 and chronic low-grade inflammation

Long-term adjunctive treatment of chronic heart failure patients with Coenzyme Q10 supplements is safe and has improved the patients’ symptoms and has reduced the patients’ risk of major adverse cardiovascular events.  Now, researchers have begun to investigate whether adjunctive treatment with Coenzyme Q10 reduces chronic low-grade inflammation.

Chronic, low-grade, systemic inflammation is common in many diseases: cardiovascular disease, metabolic syndrome, non-alcoholic fatty liver disease, obesity, type-2 diabetes [Zhai 2017].  Anti-inflammatory drugs give modest improvement at best and are associated with long-term adverse effects [Esser 2015].  Some researchers have begun to investigate whether Coenzyme Q10 as an adjunctive treatment has anti-inflammatory health benefits.

The results of the KiSel-10 study have shown that daily supplementation with 200 milligrams of Coenzyme Q10 and 200 micrograms of SelenoPrecise® selenium significantly reduced the levels of sP-selectin and hs-CRP, both markers for inflammation, as compared to placebo supplementation.

Read more

Coenzyme Q10 and energy for the immune system

The immune system protects us against bacterial and viral infections. Coenzyme Q10 is an important bio-nutrient for the optimal functioning of the immune system. It helps to provide energy for the bio-synthesis of immune system cells and energy for the activities of immune system cells.

Energy starvation in the immune system?  Immune system cells starved for energy?  There is a very plausible theory that chronic heart failure is a disease caused by the energy starvation of the heart muscle cells.  Lacking adequate Coenzyme Q10 – an indispensable component of the human cell respiration and oxidative phosphorylation process – the heart muscle cells produce less ATP than is needed to supply the cells with energy. (A concomitant theory holds that Coenzyme Q10, in its reduced form, also protects the heart muscle cells against oxidative damage.)

Read more