Heart Failure and Coenzyme Q10 as Adjuvant Therapy

Heart failure – it sounds scary. It is scary, but the medical term heart failure does not mean that your heart stops beating. No, instead, it means that your heart can’t pump enough blood and oxygen to your body.

Dr. William Judy
In the 30-year study of the management of congestive heart failure patients, Dr. Judy found that CoQ10 therapy in addition to conventional medication is more effective than conventional medication alone; however, the patients’ response to the CoQ10 adjunctive treatment is fairly slow, with peak improvements coming within 8 – 12 months. The conventional medication plus CoQ10 therapy is safe; it improves long-term survival compared to conventional medication alone.

Heart failure may develop because the heart muscle has weakened or has become thicker and stiffer. Your heart muscle can compensate for a period, but, eventually, you will need treatment.

The thing to remember is that the heart tissue is muscle tissue. As such, it needs a constant supply of ATP energy, and Coenzyme Q10 is essential to the process of ATP energy generation [Crane 2001]. Furthermore, the heart muscle tissue needs protection against the oxidative damage caused by harmful free radicals, and Coenzyme Q10 in its reduced form is an important antioxidant [Crane 2001].

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Combined Coenzyme Q10 and Selenium Supplementation

There is a special biological interrelationship between Coenzyme Q10 and selenium. From a cardiologist’s perspective, there is a theoretical advantage in using both substances to prevent heart disease if the patients’ intakes are sub-optimal [Alehagen & Aaseth 2015a].

Heart chambers
Four years of daily supplementation of senior citizens with a combination of Coenzyme Q10 and selenium resulted in reduced risk of death from heart disease and in improved heart function.

This advantage has been demonstrated in the outcomes of the KiSel-10 Study, a randomized controlled trial that enrolled elderly community dwelling Swedish citizens, average age 78 years, with known low serum selenium status (mean: 67.1 mcg/L) [Alehagen 2013; Alehagen 2016a; Alehagen 2016b].

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Coenzyme Q10 Protects Against Oxidative Stress and Inflammation

Herewith summaries of 2020-2021 meta-analyses of randomized controlled trials of Coenzyme Q10 supplementation for protection against oxidative stress and chronic inflammation. Note: A meta-analysis is a specific procedure for the pooling and evaluating of data from many individual studies for the purpose of getting more precise results.

CoQ10 and Protection Against Oxidative Stress

Hajiluian et al. investigated the antioxidant effect of CoQ10 supplementation in an analysis of 17 randomized controlled trials enrolling 972 participants. The aggregated data showed that CoQ10 supplementation is associated significantly with increased serum total antioxidant capacity, with increased superoxide dismutase levels, and with decreased malondialdehyde levels compared to the placebo group. The researchers concluded that CoQ10 supplementation improves antioxidant protection against oxidative damage caused by reactive oxygen species.

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Coenzyme Q10 and Immune Function

Coenzyme Q10 supplementation, already especially well-regarded for the prevention and adjunctive treatment of heart failure, has biological importance for immune system function [Mortensen 2014; Mortensen 2019].

Insider's Guide to Coenzyme Q10
The best guide to clinical studies of Coenzyme Q10 supplementation is Dr. William Judy’s Insider’s Guide to Coenzyme Q10, available from amazon.com. ISBN: 978-87-7776-186-7.

Administration of Coenzyme Q10 is also recommended for the treatment of statin-associated muscle symptoms [Raizner & Quiñones 2021].

Randomized controlled clinical studies have also shown that CoQ10 supplementation can help to prevent or treat such disorders as diabetes [Mantle 2017], non-alcoholic fatty liver disease [Mantle 2020], chronic kidney disease [Hargreaves 2019], and migraine [Sazali 2021].

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