There are two issues concerning the use of statin medications that relate to Coenzyme Q10.
The more serious issue is that several animal and human studies have shown that the administration of statin medications leads to a reduction in the plasma and muscle tissue levels of Coenzyme Q10. There is no doubt that depletion of Coenzyme Q10 is an unintended consequence of taking statin medications. Some human trials have shown the extent of the reduction to be 40 % or greater. Furthermore, ageing seems to play a role in the diminution of Coenzyme Q10 levels caused by the administration of statin medications [Deichmann]. Decreased plasma and heart muscle tissue levels of Coenzyme Q10 are associated with the increasing severity of heart failure [Folkers, Mortensen].