Coenzyme Q10 for People Over 65 Years of Age

Sufficient intakes of Coenzyme Q10 are increasingly important as we age. Our bodies synthesize less and less Coenzyme Q10 as we progress from middle age to our senior years. One estimate is that the CoQ10 status of an 80-year-old man’s heart muscle cells will be about half of what is normal in a 20-year-old man [Alehagen 2015].

Guillermo Lopez-Lluch
Prof. Guillermo Lopez-Lluch says that older people who have more symptoms of fragility also have lower concentrations of Coenzyme Q10 their blood plasma. The study data show that this relationship is more common in women than in men.

Sub-optimal levels of Coenzyme Q10 are associated with ageing, energy insufficiency, cardiovascular disease, stroke, and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease [Why Humans 2022].

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Combined Coenzyme Q10 and Selenium Supplementation

There is a special biological interrelationship between Coenzyme Q10 and selenium. From a cardiologist’s perspective, there is a theoretical advantage in using both substances to prevent heart disease if the patients’ intakes are sub-optimal [Alehagen & Aaseth 2015a].

Heart chambers
Four years of daily supplementation of senior citizens with a combination of Coenzyme Q10 and selenium resulted in reduced risk of death from heart disease and in improved heart function.

This advantage has been demonstrated in the outcomes of the KiSel-10 Study, a randomized controlled trial that enrolled elderly community dwelling Swedish citizens, average age 78 years, with known low serum selenium status (mean: 67.1 mcg/L) [Alehagen 2013; Alehagen 2016a; Alehagen 2016b].

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Coenzyme Q10 and the Elderly

As we get older, staying active and maintaining our physical capacity is important if we are to avoid becoming frail and vulnerable to falls.

Elderly couple
In this article, we present information about the relationship of plasma Coenzyme Q10 status to the physical capacity and the frailty of elderly individuals.

Combining daily Coenzyme Q10 supplementation with daily physical activity is good therapy for avoiding sarcopenia, which is the clinical name for the loss of muscle mass caused by ageing.

Professor Guillermo Lopez-Lluch and his colleagues in Sevilla, Spain, have reported the following results from a cross-sectional study of 64 volunteers, 47 women and 17 men. Thirty-two of the volunteers in the study were between 65 and 75 years old, and 32 volunteers were 76 years or older [de la Bella-Garzón 2022].

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Coenzyme Q10 Supplementation for Elderly Persons

Supplementation with Coenzyme Q10 has primarily made use of the oxidized form called ubiquinone. It is the stable form of Coenzyme Q10, the form with which all the important clinical studies have been done involving elderly persons, heart failure patients, and Gulf War Illness patients [Alehagen 2013; Golomb 2014; Mortensen 2014].

Walk in autumn weather
When we reach the September of our years, our cells synthesize less and less of Coenzyme Q10, the essential bio-nutrient that is needed for ATP energy generation, for antioxidant defense against harmful free radicals, and for anti-inflammatory effects.

In study participants with low baseline selenium status, the combination of Coenzyme Q10 together with the essential trace element selenium appears to reduce the level of oxidative stress and inflammation and to delay or ameliorate the development of some age-related disorders [Aaseth 2021].

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