What we have been missing until now is a good study comparing the absorption of the more stable ubiquinone Coenzyme Q10 supplements with the absorption of the newer and less stable ubiquinol Coenzyme Q10 supplements head-to-head. Now, the Coenzyme Q10 researchers at the University of Sevilla in Spain have carried out a direct comparison study in which the same study participants have been tested, with appropriate wash-out periods, on both ubiquinone and ubiquinol supplements.
The result: One well-formulated ubiquinone Coenzyme Q10 preparation – the same preparation used in the Q-Symbio study, the KiSel-10 study, and the Gulf War Illness study – has tested out significantly better than the ubiquinol preparation. This particular ubiquinone Coenzyme Q10 supplement had nearly twice the absorption response as did the ubiquinol supplement in the study.
In line with other technologies, the production technology for Coenzyme Q10 nutritional supplements has advanced over the years. For the past 35 years, Dr. William Judy of the SIBR Research Institute has followed the development of the Coenzyme Q10 nutritional supplements produced in the USA and around the world.
Dr. Judy has seen considerable improvement in the formulations of the Coenzyme Q10 nutritional supplements and in their effectiveness as an adjuvant treatment of chronic heart failure and other clinical conditions. He has seen increasing awareness of the need for Coenzyme Q10 supplements in patients taking statin medications. He has seen increasing awareness of the health benefits for healthy middle-aged and elderly people.
In this three-part series of articles, we have been discussing the absorption and bio-availability of the vital bio-nutrient Coenzyme Q10. As we come into middle age and then into our senior years, we produce less and less Coenzyme Q10 ourselves. Plus, certain medications — statin medications in particular — inhibit our bodies’ production of Coenzyme Q10 even more. And, we know that adequate intakes of Coenzyme Q10 are necessary for good heart health and a decent quality of life.
Once we have swallowed a Coenzyme Q10 capsule, what happens next? Specifically, what happens as the Coenzyme Q10 flows from the stomach to the blood? As it turns out, we know a fair amount about the transfer of the Coenzyme Q10.
The basics of Coenzyme Q10 absorption
Dr. William Judy’s study of Coenzyme Q10 absorption in large animals (large dogs that are conscious during the testing) and in humans have resulted in the following understanding:
Coenzyme Q10 is absorbed in the form of ubiquinone
Coenzyme Q10, regardless of whether it is taken in the form of ubiquinone supplements or in the form of ubiquinol supplements, will be absorbed in the small intestine in the form of ubiquinone.
Coenzyme Q10 is a vitamin-like substance that is an essential bio-nutrient. It is vital for the cellular process of ATP energy production. It is an important antioxidant protecting the cells against harmful free radicals. It is thought to improve epithelial cell function in the blood vessels and to protect against the development of atherosclerosis and high blood pressure. In this essay, we review some of the basic facts of Coenzyme Q10 absorption and bio-availability.
Importance of Coenzyme Q10 absorption Coenzyme Q10 bio-synthesis declines with age
Our bodies produce Coenzyme Q10 in much the same way that they produce cholesterol. However, once we reach our 20’s, our bio-synthesis of Coenzyme Q10 begins to decline with increasing age [Kalén]. One estimate is that the plasma Coenzyme Q10 concentration of an average 65-year-old will be only about half the plasma concentration of an average 25-year-old: approximately 0.65 micrograms per milliliter versus 1.35 micrograms per milliliter.
Okay, from solid research results, we know several things about the essential bio-nutrient Coenzyme Q10.
our bodies produce Coenzyme Q10, which is an essential substance for our cells’ energy production and for the antioxidant protection of our cells
once we reach our 20’s, our body’s own production of Coenzyme Q10 decreases with increasing age
statin medications inhibit our bodies’ production of Coenzyme Q10
we are very unlikely to get all the Coenzyme Q10 that we need from our food
the risk of heart disease and other diseases increases with the lesser availability of Coenzyme Q10
we need a daily Coenzyme Q10 supplement.
Coenzyme Q10 levels in tissue cell and in plasma Basic fact: Plasma Coenzyme Q10 levels will always exceed tissue cell Coenzyme Q10 levels except, possibly, in some very well-conditioned athletes, e.g. soccer players and cross-country skiers and cyclists. In some superior athletes, the tissue cell Coenzyme Q10 levels and the plasma Coenzyme Q10 levels may come close to being equal.
How does Coenzyme Q10 get from the blood to the cells?
Coenzyme Q10 molecules move from the blood into the tissue cells by the process of diffusion. If plasma Coenzyme Q10 concentrations were lower than the tissue cell Coenzyme Q10 concentrations, then the diffusion of Coenzyme Q10 from the blood into the tissue cells could not take place. There would need to be some sort of active transport of Coenzyme Q10 into the tissue cells, and we know of no active transport of Coenzyme Q10 into the tissue cells [Judy 2016].
Dr. William V. Judy earned his doctorate degree in physiology and bio-physics in 1971. He has worked as an aerospace scientist in NASA’s manned spacecraft center and has taught in the Indiana University School of Medicine as a Professor of Physiology. Dr. Judy has worked in basic and clinical research for 56 years now; the major focus of his research has been on the absorption, efficacy, and safety of Coenzyme Q10. He was an early colleague of Dr. Karl Folkers, with whom he carried out joint research studies for 21 years. Absorption of Coenzyme Q10 from supplements
Dr. Judy makes the following points about the absorption of Coenzyme Q10:
In this article, I look back over the past 80 q10facts.com articles and pick out my favorites. Together, these articles give a good picture of what I have tried to present on this website: documented results from scientific studies of the absorption, safety, and efficacy of Coenzyme Q10 supplements in the form of ubiquinone. At the present time, there simply is not the same quality or quantity of research results related to the use of Coenzyme Q10 supplements in the ubiquinol form.
Coenzyme Q10’s therapeutic value This article summarized the clinical research evidence for the use of Coenzyme Q10 as an adjunctive therapy for the following patients:
NQO1 gene? … NQO-1 enzymes? … I don’t remember reading or hearing about the NQO-1 gene in all of the years that I have been taking Coenzyme Q10 supplements. But, for Dr. William Judy, the NQO-1 gene seems to be one of the three or four Q10 questions that he has been most preoccupied with for several years.
NQO-1 gene important in the biochemistry of Coenzyme Q10
NQO-1 is used as shorthand for both the gene and the oxidoreductase enzymes that the gene codes for. The NADPH-Quinone Oxidoreductase-1 gene – to give it its full name – is the gene that codes in humans for the production of enzymes that reduce quinones to hydroquinones.
What is becoming more and more apparent about the absorption of Coenzyme Q10 nutritional supplements? I have been putting together the information that I have been reading and hearing. Here is what seems to be the case:
Raw material Coenzyme Q10: not the big difference maker
The Coenzyme Q10 raw material from the biggest producers of the dry powder crystalline substance seems to be comparable to a high degree. There seems to be equivalency of quality in the Coenzyme Q10 raw material. What counts is how the maker of Coenzyme Q10 supplements processes that raw material.