Coenzyme Q10 Ameliorates Statin-Associated Muscle Symptoms

Richard Morrill Statins September 17, 2019February 28, 2020 0 Comment

In his 2018 book entitled Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More: An Insider’s Guide, Dr. William V. Judy describes the complicated relationship between Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More and statin medications. Please see pages 80-85. The book is available from amazon.com.

A 2018 meta-analysis and systematic review has shown that Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplementation significantly ameliorates statin-induced muscle symptoms [Qu]:

reduces muscle pain
reduces muscle weakness
reduces muscle cramping
reduces muscle fatigue

The positive results of the meta-analysis suggest that Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplementation may be a complementary approach to the management of statin-induced myopathy [Qu].

Why Do You Need Coenzyme Q10 Supplements with Statin Medication?

Statin medications are drugs widely prescribed in order to lower patients’ levels of total cholesterolCholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... More and the so-called “bad” ldl-cholesterol. StatinsStatins are a class of medications that effectively block the body’s synthesis of cholesterol. In so doing, statins also block the body’s synthesis of Coenzyme Q10.... More are used to protect against heart attack and stroke; however, they do have adverse effects.

Coenzyme Q10 and statin medications

Richard Morrill Cardiovascular Health, Statins May 8, 2018May 8, 2018 0 Comment

A set of pharmacological mechanisms suggests that the use of statin medications may be stimulating the development of atherosclerosisAtherosclerosis is the thickening of the artery walls brought about by the build-up of plaque (plaque is made up of cholesterol and other fatty substances and waste products and calcium and fibrin) and the subsequent slowing of the flow of blood through the clogged arteries. More research is needed into the role of Coenzyme Q10 in the prevention and adjunct... More and chronic heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... More. Japanese and American researchers have documented the mechanisms by which statin medications may be causing coronary artery calcification. They propose that the guidelines regulating the use of statin medications be critically re-evaluated [Okuyama 2015].

Statin medications reduce total and bad cholesterolCholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... More levels but may not reduce the extent of atherosclerosisAtherosclerosis is the thickening of the artery walls brought about by the build-up of plaque (plaque is made up of cholesterol and other fatty substances and waste products and calcium and fibrin) and the subsequent slowing of the flow of blood through the clogged arteries. More research is needed into the role of Coenzyme Q10 in the prevention and adjunct... More or the risk of chronic heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... More. Attribution: By BruceBlaus [CC BY-SA 4.0 (https://creativecommons.org/licenses/by-sa/4.0)], from Wikimedia Commons.

If the researchers are correct, then, yes, statin medications do reduce total cholesterolCholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... More and bad cholesterolCholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... More levels. However, statin medications may not reduce the incidence of coronary heart disease. Furthermore, statin medications may be at least partially responsible for the increased incidence of chronic heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... More that has been observed in the period since statin medications were introduced in 1987.

Coenzyme Q10, older athletes, and statins

Richard Morrill Antiaging, Antioxidant function, Exercise and Training, Healthy People, Statins April 26, 2017April 26, 2017 0 Comment

woman-exercising — The more intensely and strenuously we exercise, the more quickly we reach the anaerobic threshold. A 2012 study has shown that 200 milligrams of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More daily can significantly delay the time to the anaerobic threshold. The Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplementation was also associated with significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... More improvement in muscle strength in the study.

Older active adults who are taking a statin medication? Shouldn’t they go right to the top of the list of people who need a good Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplement?

That is the question that Dr. Richard Deichmann and his colleagues in the Department of Internal Medicine at the Ochsner Clinical School in New Orleans asked themselves. They tested whether daily supplementation with 200 milligrams of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More daily for six weeks would improve measures of cellular energy production, muscle function, and well-being in older active adults taking statin medications.

Coenzyme Q10 and selenium: partners against heart disease

Richard Morrill Antioxidant function, Cardiovascular Health, Healthy People, Statins, Ubiquinol, Uncategorized December 16, 2015January 4, 2017 2 Comments

Surgeons and hospitalized patient — Swedish seniors, both men and women, who took Q10 and seleniumSelenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... More supplements for a 4-year period spent 13% fewer days in the hospital and had significantly better quality of life than did Swedish seniors who took placebos.

There is a tantalizingly interesting relationship between the essential bio-nutrient Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More and the trace element seleniumSelenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... More and heart disease. One of the first clinical researchers to tease out the effects of supplementation with Q10 and seleniumSelenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... More in heart attack patients was Dr. Bodo Kuklinski.

Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More and seleniumSelenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... More for heart attack patients
Dr. Kuklinski tested 61 patients who had been admitted to the hospital in Rostock, Germany, with an acute myocardial infarctionMyocardial infarction is the medical term for heart attack. Coenzyme Q10 supplementation is associated with improved recovery and less risk of re-hospitalization following a heart attack.... More and with symptoms of less than six hours’ duration. He assigned 32 of the patients to the adjuvant treatment group and 29 of the patients to the control group.

Ubiquinone? Ubiquinol? What does Dr. Judy say?

Richard Morrill Cardiovascular Health, Statins September 10, 2015August 13, 2018 0 Comment

Dr. William V. Judy, himself a 16-year survivor of a heart attack, takes 200 mg a day of a ubiquinoneUbiquinone, the oxidized form of Coenzyme Q10, expressed as Q10 or CoQ10, is absolutely essential for the mitochondrial ATP energy production process. Ubiquinone is the form of Coenzyme Q10 that the body synthesizes, and ubiquinone is the form of Coenzyme Q10 that has been extensively tested for safety, absorption, and efficacy in clinical trials.... More Q10 supplement. The normal life span for Class IV Chronic Heart FailureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... More patients is 7 years when taking conventional therapy only.

Difference between Q10 searches in Medline and Google
When I look at Medline for reports of randomized controlled trialsRandomized controlled trials are studies in which patients or healthy volunteers are assigned at random (purely by chance) to receive one or more clinical interventions. One or more of the interventions is the active treatment being tested. Another of the interventions is the control against which the active treatment is being tested. The control is, typically, the standard practice or... More (RCTs) showing the effects of Q10 supplementation, I find mostly studies using the ubiquinoneUbiquinone, the oxidized form of Coenzyme Q10, expressed as Q10 or CoQ10, is absolutely essential for the mitochondrial ATP energy production process. Ubiquinone is the form of Coenzyme Q10 that the body synthesizes, and ubiquinone is the form of Coenzyme Q10 that has been extensively tested for safety, absorption, and efficacy in clinical trials.... More form. It is the well-documented form.

When I use Google to look for new information about Q10 supplements, I find more claims than I find reports of research results. In Google, the ratio of ubiquinol claims to ubiquinoneUbiquinone, the oxidized form of Coenzyme Q10, expressed as Q10 or CoQ10, is absolutely essential for the mitochondrial ATP energy production process. Ubiquinone is the form of Coenzyme Q10 that the body synthesizes, and ubiquinone is the form of Coenzyme Q10 that has been extensively tested for safety, absorption, and efficacy in clinical trials.... More claims is much higher than the ratio of ubiquinol-to-ubiquinone research results is in Medline. That is strange.

Fewer hospital visits with Q10

Richard Morrill Antiaging, Bioavailability and Safety, Cardiovascular Health, Musculoskeletal system, Statins September 9, 2015September 23, 2015 1 Comment

Hospital beds in paint — Being re-admitted to the hospital is hard on the patient and the family and the hospital system. Judicious use of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More supplements can reduce the number of re-hospitalizations.

The energy-starved heart. More than anyone, the Danish cardiologist Dr. Svend Aage Mortensen was the person who wanted to do clinical research into the phenomenon of the failing heart that was starved for energy. He thought that there was an issue in heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... More patients with heart cell mitochondriaThe mitochondria are the bean-shaped organelles in the cells. They are the key organelles with responsibility for the production of ATP energy molecules.... More colonizing and atrophying adjacent to the cell membranesThe cell membranes, sometimes called plasma membranes, are the physical barrier that protects the contents of the cells from everything that is outside the cells. The cell membranes also regulate what can move in and out of the cells. Coenzyme Q10 is present in all cell membranes in the body except in the red blood cells. It helps to prevent... More.

Less Q10 with age and with statin medications
Dr. Mortensen thought that the issue was closely related to an inadequate supply of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More. As people got older, their bodies produce less Q10. They also absorb less Q10 if they begin to eat smaller meals and less meat and fish. Moreover, he knew that patients taking statin medications were having their own bio-synthesis of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More blocked by the statin medications.

Following Q10 from the stomach to the cells

Richard Morrill Antiaging, Bioavailability and Safety, Statins July 7, 2015 0 Comment

Q10 C59 H90 O4 — The Q10 molecules are large fat-soluble molecules. They have somewhat hydrophilic heads and strongly hydrophobic tails. As such, they need to form into micelles to move into the watery phase near the absorption cells in the small intestine.

Earlier, I asked Dr. William Judy about drug delivery systems using nanoparticles.
Could the use of nanoparticles be a good way to increase the absorption of Q10 molecules?

Dr. Judy looked at the published research literature and decided that, given the present state of research and development, nanoparticles are still not as effective as the body’s own micelles for the delivery of Q10 to the absorption cells in the small intestine.

Q10 difficult to absorb
To recapitulate: Coenzyme Q10 is difficult to formulate in a way that ensures that it will be absorbed in the small intestine. There are several reasons for this difficulty:

Weak arguments for the ubiquinol form of Q10

Richard Morrill Bioavailability and Safety, Healthy People, Statins July 5, 2015 0 Comment

Red flag — The use of logical fallacies in advertisements for Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More products should raise a red flag in your mind. Fallacies are false and misleading arguments based on faulty evidence or on faulty reasoning or both.

Often, people who have only weak evidence or weak reason and logic to support their arguments resort to the use of logical fallacies. Far too often, for example, we see fallacies used in commercial advertisements and in political campaigns. Some of the most recognizable fallacies used (unfairly) in arguments and in discussions are the appeal to emotion, the appeal to tradition, the ad hominem attack, the straw man, the red herring, the slippery slope, and so on. We have to be on guard against the use of these fallacies.

Meta-analyses of Q10 in heart failure

Richard Morrill Bioavailability and Safety, Cardiovascular Health, Statins May 8, 2015 0 Comment

Illustration for metaanalysis — Three solid meta-analyses provided the background data and information that led to the design and funding of the Q-Symbio studyQ-Symbio is the abbreviated name for the two-year multi-center, randomized, double-blind, placebo-controlled study of Coenzyme Q10 supplements as an adjunct treatment of chronic heart failure patients. The name reflects the focus of the study on the SYMptoms, BIomarker status (BNP), and long-term Outcomes (hospitalizations and mortality) of the supplementation. The data from the Q-Symbio study show that long-term supplementation with... More of the effects of Q10 supplementation on chronic heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... More.

Why do a meta-analysis of Q10 studies? And, what is a meta-analysis anyway?
A meta-analysis is a statistical method for the combining of the results from two or more independent studies of the effects of the same treatment variable on the same or similar outcomes. In our case, the supplementation with Q10 is the independent variable, the treatment variable, and the various aspects of heart disease are the dependent variables. The meta-analysis method is used in the hope of gaining greater knowledge of the efficacy of bio-medical treatments through the combining and comparing and contrasting of the data from the studies selected for analysis.

Diabetes and statins and Q10

Richard Morrill Bioavailability and Safety, Cardiovascular Health, Statins March 23, 2015 0 Comment

Nurse taking blood for blood sugar test — Yes, statin medications lower cholesterolCholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... More levels, and yes, the incidence of heart attacks has fallen somewhat, but, at the same time, statin medications inhibit the body’s production of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More, and the incidence of heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... More is increasing.

Lipitor (atorvastatin), the cholesterolCholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... More reducing statin medication sold by the Pfizer Corporation, is the number one best-selling prescription drug of all time. In fact, two of the top five best-selling prescription drugs of all time are statin medications (Crestor being the other one). Rounding out the top five are a blood thinning medication, an asthma medication, and an arthritis medication.

cholesterolCholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... More and Q10 — the same biological pathway
For some time now, we have known that Lipitor and the other statin medications inhibit not only the body’s production of cholesterolCholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... More but also the body’s synthesis of Coenzyme Q10, a substance that is very important for cellular energy production and for antioxidantAntioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... More protection (2). This inhibition of the body’s generation of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More is not a good thing for our heart health.