Q10facts - Page 2 of 23 - CoQ10 Research Articles

Daily CoQ10 Supplementation for Senior Citizens

Richard Morrill Uncategorized December 15, 2020December 1, 2020 0 Comment

Dr. William Judy, founder and president of SIBR Research, says that individuals vary in the extent to which their cells synthesize less CoQ10 with increasing age in the adult years. Generally, though, he is concerned if an individual has a blood CoQ10 concentration below 0.60 micrograms per milliliter.

As we get older – and more susceptible to aging-related diseases – the mitochondriaThe mitochondria are the bean-shaped organelles in the cells. They are the key organelles with responsibility for the production of ATP energy molecules.... Read more about this term and the endoplasmic reticula in our cells synthesize significantly less Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term. This seems to be especially true of CoQ10 bio-synthesis in the heart muscle cells, kidney cells, leg muscle cells, and abdominal wall muscle cells [Díaz-Casado 2019].

In some human tissues, the highest levels of CoQ10 are found in 20-year-olds. After the 20’s comes the ageing-related decline in CoQ10 levels in various human tissues [Kalén 1989].

Low Coenzyme Q10 Status and Increased Heart Disease Risk

Richard Morrill Cardiovascular Health November 30, 2020December 1, 2020 0 Comment

Japanese cardiologists have reported a significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... Read more about this term connection between low Coenzyme Q10 status and the risk of death from heart disease and other causes [Shimizu 2020].

The researchers collected and examined blood samples from 242 men and women admitted to Juntendo University Hospital’s coronary care unit in Tokyo.
They followed the heart disease patients for a three-year period.
58 of the 242 patients (24%) died during the follow-up period from heart disease, cancer, infection, and other causes.
The patients who died had an average blood CoQ10 concentration of 0.48 micrograms per milliliter. The patients who survived had a higher average blood CoQ10 concentration of 0.58 micrograms per milliliter.
Overall, the researchers found that patients with a “higher” blood CoQ10 concentration of 0.46 or greater micrograms per milliliter had a 52% lesser likelihood of dying from all causes than did the patients with blood CoQ10 concentrations below 0.46 micrograms per milliliter.
Nota bene: The patients with the low CoQ10 blood levels were the patients with the higher dosages of statin medications.

Why Low CoQ10 Levels are Associated with Heart Disease Mortality

Book Insider's Guide to Coenzyme Q10 — In his book Insider’s Guide to Coenzyme Q10, Dr. Judy discusses the effects of increasing age, malnutrition, and statin medications on blood Coenzyme Q10 levels and the consequent effect on heart function. Available from amazon.com. ISBN: 978-87-7776-186-7.

This research shows that heart disease patients with lower blood CoQ10 levels are at greater risk of dying sooner than heart disease patients with higher blood CoQ10 levels [Shimizu 2020].

Statin medications are known to inhibit the body’s endogenous production of Coenzyme Q10; logically, every heart patient taking a statin medication will need adjunctive Coenzyme Q10 treatment. Okuyama et al [2015] have explained the mechanisms by which statin medication may increase the risk of developing atherosclerosisAtherosclerosis is the thickening of the artery walls brought about by the build-up of plaque (plaque is made up of cholesterol and other fatty substances and waste products and calcium and fibrin) and the subsequent slowing of the flow of blood through the clogged arteries. More research is needed into the role of Coenzyme Q10 in the prevention and adjunct... Read more about this term and heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term.
Lower blood CoQ10 levels are also associated with greater age [Shimizu 2017]. Malnutrition among senior citizens may be contributing to low CoQ10 status; this is another argument for supplementation.
Adequate levels of Coenzyme Q10 are associated with reduced levels of blood bio-markers for inflammationInflammation is an immune system response to an injury to cells or tissues. It is the body’s attempt to defend against invaders such as bacteria andviruses and to mend the damage done by invaders. Typically, inflammation manifests itself in the form of fever and swelling, in the swarming of white blood cells and the release of cytokines to fight against... Read more about this term, in particular interleukin 6, C-reactive protein, and tumor necrosis factor alpha [Fan 2017].

Evidence from CoQ10 Supplementation and Heart Disease Studies

Professor Urban Alehagen’s KiSel-10 Study has shown that daily supplementation of senior citizens with Coenzyme Q10 and selenium-enriched yeast for four years cuts the risk of heart disease in half [Alehagen 2013].
Professor Svend Aage Mortensen’s Q-Symbio Study has shown that adjunctive treatment of chronic heart failure patients with Coenzyme Q10 for two years significantly reduces the risk of death from heart disease and of death from all causes [Mortensen 2014; Mortensen 2019].

Bottom Line: CoQ10 Status and Cardiovascular Disease risk

Adequate levels of Coenzyme Q10 are essential to the cells’ production of ATPATP (adenosine triphosphate) molecules are the high-energy molecules with easily broken phosphate bonds that release energy to the energy-requiring processes in the cells. Coenzyme Q10 is essential to the process of ATP production.... Read more about this term energy; moreover, Coenzyme Q10 is an important lipid-soluble antioxidantAntioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term that scavenges harmful free radicalsFree radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... Read more about this term [Shimizu 2017].

CoQ10 for Dogs and Cats

Richard Morrill Cardiovascular Health November 14, 2020November 6, 2020 0 Comment

Myxomatous mitral valve disease is the most common heart disease in dogs. It often leads to congestive heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term. The Cavalier King Charles Spaniel is especially at risk of developing mitral valve disease at an early age. From the onset of congestive heart failureThe Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term in dogs with mitral valve disease, the median survival time is less than a year even with medical therapy [Christiansen 2020]. Applied early enough, Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term supplements may increase the life expectancy and quality of life for dogs at risk of heart disease.

Increasingly, people are feeding their dogs CoQ10 supplements. The CoQ10 supplementation is used provide dogs and cats the following health benefits [Gollakner 2020; Puotinen CJ 2019]:

improved cellular energy production
enhanced antioxidantAntioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term protection against lipid peroxidationOxidation is the chemical reaction of a substance with oxygen. Peroxidation is the extreme form of oxidation that results from free radicals’ stealing electrons from lipids, either in the cell membranes or in the lipoproteins. The final product of lipid peroxidation is highly reactive malondialdehyde, a bio-marker for oxidative stress and damage.... Read more about this term
anti-inflammatory effects
reduced endothelial dysfunctionEndothelial dysfunction may be thought of as the failure of the cells lining the inside of arteries and veins to regulate properly blood vessel relaxation and contraction, blood clotting, immune function, and platelet adhesion. Endothelial dysfunction prevents the blood vessels from dilating sufficiently and can lead to increased risk of atherosclerosis, heart attack, and stroke. Coenzyme Q10 supplementation is associated... Read more about this term

Typically, the CoQ10 supplement is given by mouth as a capsule or as a liquid. It is possible, of course, to squeeze the CoQ10 filling out of a capsule onto the dog food.

Pharmacokinetics Study of Repeated Oral CoQ10 Dosing of Spaniels

Now, a research team in Denmark has investigated the pharmacokinetics of oral dosing of Cavalier King Charles Spaniels over a three-week period [Christiansen 2020].

CoQ10 and Oxidative Stress: A 2020 Meta-analysis

Richard Morrill Antioxidant function October 30, 2020September 16, 2020 0 Comment

Dr. Judy An Insider's Guide to Coenzyme Q10 — Dr. William V. Judy, founder and president of SIBR Research, explains the differences between the ubiquinoneUbiquinone, the oxidized form of Coenzyme Q10, expressed as Q10 or CoQ10, is absolutely essential for the mitochondrial ATP energy production process. Ubiquinone is the form of Coenzyme Q10 that the body synthesizes, and ubiquinone is the form of Coenzyme Q10 that has been extensively tested for safety, absorption, and efficacy in clinical trials.... Read more about this term form of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term and the ubiquinol form. The book is available from amazon.com. ISBN 978-87-7776-186-7.

First off, a few definitions:

Coenzyme Q10 is an essential bio-nutrient with vitamin-like properties. It is not considered a vitamin because our cells do synthesize Coenzyme Q10. However, once we reach adulthood, our bio-synthesis of Coenzyme Q10 begins to decline with increasing age [Kalén 1989]. Furthermore, statin medications are known to inhibit the bio-synthesis of Coenzyme Q10 [Okuyama 2015]. Supplementation is a must.

Oxidative stress is the result of an imbalance between the body’s production of harmful free radicalsFree radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... Read more about this term as a by-product of metabolic processes and the body’s supply of antioxidants to neutralize the free radicals. Oxidative stress, unchecked, results in damage to cell membranesThe cell membranes, sometimes called plasma membranes, are the physical barrier that protects the contents of the cells from everything that is outside the cells. The cell membranes also regulate what can move in and out of the cells. Coenzyme Q10 is present in all cell membranes in the body except in the red blood cells. It helps to prevent... Read more about this term, proteins, lipids, and DNA.

Higher Plasma CoQ10 Levels, Lower Levels of Muscle Damage

Richard Morrill Exercise and Training October 15, 2020October 26, 2020 0 Comment

Soccer stadium — The study participants were professional players of the Athletic Club Bilbao team that competed in the first division of the Spanish soccer league during the 2014/15 and 2015/16 seasons. Cumulative exhaustive exercise causes oxidative stress and damage to muscle cells; it also depletes the levels of Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term in plasma, showing that the Coenzyme Q10 has been active as an antioxidantAntioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term during the intense exercise. Higher CoQ10 levels can protect against the damage caused by strenuous exercise.

Data from a two-year observational study indicate that maintaining high levels of Coenzyme Q10 in plasma during the hardest part of the soccer season helps professional players [Sanchez-Cuesta 2020]:

prevent muscle damage (lower creatine kinase levels)
prevent kidney damage (lower uric acid levels)
reduce stress (lower cortisol levels)
achieve higher physical capacity (video analysis of distance run and running speed)

Based on the results of the observational study, the researchers speculated that CoQ10 can be safely used as a supplement for the prevention of accumulated muscle and kidney damage in elite athletes, possibly even for improving recovery time after intense competition [Sanchez-Cuesta 2020].

Coenzyme Q10 in Plasma is Predominantly in the Ubiquinol State

Coenzyme Q10 molecules are redox molecules with an oxidized state (ubiquinone) and a reduced state (ubiquinol). The Coenzyme Q10 in the plasma is predominantly in the reduced CoQ10 state, i.e. in the state that serves as an electron donor, making it the ideal state for antioxidant neutralization of harmful free radicalsFree radicals are unstable and highly reactive molecules that are produced in the body during normal oxygen metabolism. Free radicals derived from oxygen are known as reactive oxygen species. Free radicals play both helpful and harmful roles in the body. Free radicals steal electrons from other substances in order to become stable. In so doing, the free radicals oxidize those... Read more about this term [Judy 2018].

CoQ10 and Aging – A New Book

Richard Morrill Antiaging September 30, 2020September 14, 2020 0 Comment

Professor Lopez-Lluch and Professor Littarru — **Professor Guillermo López-Lluch (left), editor of the book Coenzyme Q and Aging, 2020, published by Springer Nature. ISBN: 978-3030456412.**

Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term is important to our understanding of the progression of the aging process and to our understanding of aging-related diseases such as cancer, cardiovascular disease, metabolic syndromeMetabolic syndrome is the medical term for a cluster of conditions such as excess body fat around the waist, high blood sugar, high blood pressure, high cholesterol or triglyceride levels. Metabolic syndrome is associated with increased risk of diabetes, heart disease, and stroke. Individuals with metabolic syndrome are at higher risk of heart disease, diabetes, and stroke and have, therefore,... Read more about this term and diabetes, neurodegenerative disorders, and kidney diseases [López-Lluch 2020].

This is the message of a 369-page book entitled Coenzyme Q in Aging. The book is edited by Professor Guillermo López-Lluch, Pablo de Olavide University, Sevilla, Spain. It is dedicated to the memory of Professor Fred L. Crane (December 3, 1925 – August 11, 2016), who first discovered Coenzyme Q10, one of the most important molecules in humans [López-Lluch 2020].

CoQ10 Supplementation to Improve Fertility in Women

Richard Morrill Fertility September 15, 2020September 16, 2020 0 Comment

Storch bringing baby — Three meta-analyses show beneficial effects of CoQ10 supplementation on semen quality, semen quantity, and semen mobility. Here, a meta-analysis of studies of CoQ10 supplementation of women with infertility shows a significantThe outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... Read more about this term effect on clinical pregnancy rates.

A meta-analysis of five randomized controlled clinical studies (n=449 infertile women) has shown that CoQ10 supplementation increases clinical pregnancy rates compared with placebo treatment or no treatment. The CoQ10 supplementation significantly increases clinical pregnancy rates both overall and in infertility subgroups such as the poor ovarian response subgroup (n=286) and the polycystic ovarian syndrome subgroup (n=163) [Florou 2020].

All study participants were women of reproductive age (mean age 33 years) diagnosed with either poor ovarian response or polycystic ovary syndrome. All were attending an assisted reproductive technology clinic [Florou 2020].

Testing CoQ10 Products for Quality

Richard Morrill Bioavailability and Safety August 31, 2020September 16, 2020 0 Comment

Lab scientist — CoQ10 products are not equally well absorbed. They do not give equally good health benefits. The bioavailability and the efficacy of the CoQ10 product varies considerably according to the formulation of the product. Consumers of CoQ10 products should seek out documentation for bioavailability and health benefits.

The CoQ10 Association has announced plans to test every Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term product on the market in the US for potency and purity [Schultz 2020, August 13]. If all goes according to plan, the project will be completed by the end of 2020. We look forward to seeing the results of the testing.

Potency of CoQ10 Products

Testing for potency means ensuring that the capsule contains the quantity of Coenzyme Q10 specified on the label.

Earlier this year, in May, 2020, the NOW nutritional supplements company headquartered in Illinois, revealed that its in-house laboratory had tested 10 CoQ10 products purchased on amazon.com.

CoQ10 for Women with Poor Ovarian Response

Richard Morrill Fertility August 15, 2020September 16, 2020 0 Comment

Pregnant woman — The reasons for a poor ovarian response to stimulation with gonadotropins are not clear. Mitochondrial dysfunctionMitochondrial dysfunction is the loss of efficiency in the process of ATP energy production. As such, mitochondrial dysfunction is a factor in the ageing process and in virtually all chronic diseases including cancer, cardiovascular diseases, chronic fatigue syndrome and fibromyalgia, diabetes and metabolic syndrome, and neurodegenerative diseases. Coenzyme Q10 is an essential component in the mitochondrial production of ATP energy.... Read more about this term and oxidative stress are possible explanations for the diminished ovarian response. Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term is essential for energy production in the mitochondriaThe mitochondria are the bean-shaped organelles in the cells. They are the key organelles with responsibility for the production of ATP energy molecules.... Read more about this term of oocytes and is important for antioxidantAntioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term protection in oocytes.

Coenzyme Q10 pre-treatment of young low-prognosis patients with diminished ovarian reserve or poor ovarian response increased the patients’ ovarian response to stimulation and improved oocyte and embryo quality.

The CoQ10 pre-treatment was associated with improved pregnancy and live birth rates.

After one completed assisted reproductive technique treatment cycle, the women treated with Coenzyme Q10 had a 32% pregnancy rate and a 29% live birth rate. The women in the control group had a pregnancy rate of 17% and a 16% live birth rate.

CoQ10 Supplements: What You Need To Know

Richard Morrill Absorption August 2, 2020September 16, 2020 0 Comment

Coenzyme Q10 capsules — The thing is, there are considerable differences in the absorption and bioavailability of the many commercial CoQ10 supplements. An inexpensive CoQ10 supplement is not inexpensive if it gives only negligible absorption and bioavailability. It is a waste of money. It is important to choose a CoQ10 supplement with documented absorption and efficacy.

The active substance in the best Coenzyme Q10Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term nutritional supplements is a natural substance that is extracted in a yeast fermentation process; the Coenzyme Q10 is not a synthetic substance.

The CoQ10 molecules in the best nutritional supplements are the same molecules as the CoQ10 molecules synthesized inside the mitochondriaThe mitochondria are the bean-shaped organelles in the cells. They are the key organelles with responsibility for the production of ATP energy molecules.... Read more about this term in human cells.

As we get older, our cells’ ability to synthesize Coenzyme Q10 declines. Furthermore, the use of some drugs such as statin medications inhibits the cells’ synthesis of Coenzyme Q10. We need a good supplement to make up for the loss.