Adiponectin is a circulating protein that plays a role in glucose metabolism and in the breakdown of fatty acids.  Plasma adiponectin concentrations are a known bio-marker for the extent of insulin resistance.  Adiponectin attenuates the inflammatory response of the immune system. Low adiponectin levels are associated with most of the negative aspects of type 2 diabetes and metabolic syndrome. Studies have shown that Coenzyme Q10 supplementation is associated with increased adiponectin levels.