Ischemia is the lack of adequate blood supply to tissues, e.g. to the heart muscle tissues. In the case of ischemia, the tissues are not getting enough oxygen. see ischemia-reperfusion., then, is the damage caused to the tissues when the blood supply is restored to the tissue, and, suddenly, there is a re-oxygenation of the tissues as, for example, in cases of heart attack or heart surgery. Clinical studies have shown that pre-treatment and post-operative treatment with Coenzyme Q10 molecules are fat-soluble molecules that are both synthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... More attenuates the extent of ischemia see ischemia-reperfusion. injury.