Two independent meta-analyses of the available research literature have shown that Coenzyme Q10 supplementation is associated with healthy levels of bio-markers for chronic systemic inflammation [Zhai 2017; Fan 2017].
- Chronic inflammation – a persistent low-grade inflammation – can have deleterious effects throughout the body. Over time, it can result in tissue damage.
- Chronic inflammation is something different from acute inflammation, which is the immune system’s short-term response to an injury or an infection.
- Chronic low-grade inflammation has been linked to increased risk of heart disease, stroke, diabetes, and metabolic disorders [Zhai 2017].
- The extent of chronic low-grade inflammation can be measured by testing for the blood levels of known bio-markers for inflammation [Zhai 2017].
Coenzyme Q10 Effect on Tumor Necrosis Factor-Alpha
Zhai et al analyzed nine Randomized controlled trials are studies in which patients or healthy volunteers are assigned at random (purely by chance) to receive one or more clinical interventions. One or more of the interventions is the active treatment being tested. Another of the interventions is the control against which the active treatment is being tested. The control is, typically, the standard practice or... Read more about this term enrolling 428 study participants. The results of their analysis showed that CoQ10 supplementation significantly improved the serum concentration of Coenzyme Q10 by 1.17 micrograms per milliliter on average compared to placebo treatment [Zhai].
Note: The cardiologist Dr. Peter H. Langsjoen has stated that it is important to raise plasma/serum CoQ10 levels above 2.5 micrograms per milliliter to have a therapeutic effect on the cardiovascular system [Langsjoen 2014].
In the Zhai meta-analysis, the increased serum CoQ10 concentrations were associated with a The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... Read more about this term decrease in the inflammation bio-marker tumor necrosis factor-alpha (TNF-α) by 0.45 picograms per milliliter.
Note: Increased blood concentrations of TNF-a are common in both acute and chronic inflammation. Reducing TNF-a levels is a potential therapeutic goal for reducing the risk of Atherosclerosis is the thickening of the artery walls brought about by the build-up of plaque (plaque is made up of cholesterol and other fatty substances and waste products and calcium and fibrin) and the subsequent slowing of the flow of blood through the clogged arteries. More research is needed into the role of Coenzyme Q10 in the prevention and adjunct... Read more about this term and diabetes and metabolic disorders [Zhai 2017].
Coenzyme Q10 and Bio-Markers of Chronic Inflammation
Fan et al examined the data from 17 randomized controlled trials enrolling 811 patients (412 assigned to the CoQ10 treatment group and 399 assigned to the placebo control group).
The researchers found that the CoQ10 supplementation was associated with a significant reduction of the blood levels of C-Reactive Protein (C-RP) and TNF-a compared to the placebo treatment. They were able to show that the reduction in C-RP levels was independent of the baseline CR-P levels, the treatment duration, the treatment dosage, and patient characteristics [Fan 2017].
The CoQ10 treatment also had a significant lowering effect on blood levels of the inflammation bio-marker IL-6 [Fan 2017].
Note: C-Reactive Protein is a protein produced in the liver. During times of elevated inflammation in the body, the concentrations of C-RP increase in the blood, making it a good bio-marker for detecting chronic inflammation.
Note: The immune system produces interleukin 6 (IL-6) at the site of the inflammation. At healthy levels, IL-6 acts as a defense mechanism; however, at elevated levels, it can have a pro-inflammatory effect [Gabay 2006].
Decrease in Inflammatory Bio-Markers with Selenium and Coenzyme Q10 Combination
Neither the Zhai study nor the Fan study included data from the KiSel-10 study conducted by Professor Urban Alehagen and a team of university researchers. Zhai and Fan concentrated on studies using a single supplement: Coenzyme Q10.
The four-year KiSel-10 study was a study of the effect of combined daily supplementation (200 milligrams of Coenzyme Q10 and 200 micrograms of high-selenium yeast) on senior citizens. The KiSel-10 study results showed the following The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant.... Read more about this term outcomes:
- reduced risk of death from heart disease
- improved heart function as seen on echocardiograms
- improved health-related quality of life
In follow-up analyses, Professor Alehagen and his team confirmed that the combined supplementation regimen was significantly associated with reductions in the levels of a number of inflammatory bio-marker concentrations [Alehagen 2015; Alehagen 2019].
Summing up: CoQ10 Supplementation and Chronic Inflammation
- Our bodies produce less and less Coenzyme Q10 as we get older [Kalen 1989].
- Coenzyme Q10 has a number of clinically important functions in the body [Littarru 2010].
- essential to the cellular generation of ATP (adenosine triphosphate) molecules are the high-energy molecules with easily broken phosphate bonds that release energy to the energy-requiring processes in the cells. Coenzyme Q10 is essential to the process of ATP production.... Read more about this term energy
- important as a fat-soluble Antioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term
- necessary for good endothelial function
- associated with reductions in bio-markers of chronic inflammation
- Coenzyme Q10 is safe, well-tolerated, effective, and affordable.
Important to Keep in Mind When Buying a Coenzyme Q10 Supplement
- Not all CoQ10 supplements are absorbed equally well. To get the anti-inflammatory effect and the beneficial heart health effects, it is important to buy a CoQ10 supplement that is well-documented.
- The formulation of the CoQ10 supplement is more important than the form of the CoQ10 supplement [Lopez-Lluch 2019]. The Ubiquinone, the oxidized form of Coenzyme Q10, expressed as Q10 or CoQ10, is absolutely essential for the mitochondrial ATP energy production process. Ubiquinone is the form of Coenzyme Q10 that the body synthesizes, and ubiquinone is the form of Coenzyme Q10 that has been extensively tested for safety, absorption, and efficacy in clinical trials.... Read more about this term form of Coenzyme Q10 is the more stable, better documented (in terms of absorption and health effects), and more affordable CoQ10 supplement.
- Adequate intakes of Coenzyme Q10 are important for energy, for immune defense, and healthy ageing.
Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., & Dahlström, U. (2013). Cardiovascular mortality and N-terminal-proBNP reduced after combined Selenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... Read more about this term and Coenzyme Q10 supplementation: a 5-year prospective randomized A double-blind study is a study in which neither the investigators nor the study participants know which participants are receiving the active treatment and which participants are receiving the control treatment until the study has been completed and the seal on the code has been broken.... Read more about this term placebo-controlled trial among elderly Swedish citizens. International Journal of Cardiology, 167(5), 1860-1866.
Alehagen, U., Lindahl, T. L., Aaseth, J., Svensson, E., & Johansson, P. (2015). Levels of sP-selectin and hs-CRP Decrease with Dietary Intervention with Selenium and Coenzyme Q10 Combined: A Secondary Analysis of a Randomized Clinical Trial. Plos One, 10(9), e0137680.
Alehagen, U., Alexander, J., Aaseth, J. & Larsson, A. (2019). Decrease in inflammatory biomarker concentration by intervention with selenium and Coenzyme Q10: a sub-analysis of osteopontin, osteoprotergerin, TNFr1, TNFr2, and TWEAK. Journal of Inflammation, 16,5,1-9.
Fan, L., Feng, Y., Chen, G.-C., Qin, L.-Q., Fu, C.-L., & Chen, L.-H. (2017). Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research, 119, 128–136.
Gabay, C. (2006). Interleukin-6 and chronic inflammation. Arthritis Res Ther; 8(Suppl 2): S3.
Kalén, A., Appelkvist E.L., Dallner G. (1989). Age-related changes in the lipid compositions of rat and human tissues. Lipids, 24(7):579–584.
Langsjoen PH & Langsjoen AM. (2014). Comparison study of plasma Coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev; 3(1):13-7.
Littarru, G-P & Tiano, L. (2010). Clinical aspects of Coenzyme Q10: an update. Nutrition, 26(3):250-4.
López-Lluch, G., Del Pozo-Cruz, J., Sánchez-Cuesta, A., Cortés-Rodríguez, A. B., & Navas, P. (2019). Bioavailability of Coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition, 57, 133–140.
Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., & Littarru, G. P. (2014). The effect of coenzyme Q10 on morbidity and mortality in The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term: results from Q-SYMBIO: a randomized double-blind trial. JACC. The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term, 2(6), 641-649.
Zhai, J., Bo, Y., Lu, Y., Liu, C., & Zhang, L. (2017). Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis. Plos One, 12(1), e0170172.
The information contained in this review article in not intended as medical advice and should not be used as such.
21 December 2019Please click here for more information about the heart health effects of Coenzyme Q10 supplementation.