Older active adults who are taking a statin medication? Shouldn’t they go right to the top of the list of people who need a good Coenzyme Q10 supplement?
That is the question that Dr. Richard Deichmann and his colleagues in the Department of Internal Medicine at the Ochsner Clinical School in New Orleans asked themselves. They tested whether daily supplementation with 200 milligrams of Coenzyme Q10 daily for six weeks would improve measures of cellular energy production, muscle function, and well-being in older active adults taking statin medications.
Lower Coenzyme Q10 levels in older people
After all, older people’s cells tend to produce less Coenzyme Q10, and older people tend to have lower plasma Coenzyme Q10 levels [Kalen 1989, Rosenfeldt 2003, Rosenfeldt 2005].
Lower Coenzyme Q10 levels associated with statin medications
If, then, the older people also take a statin medication, they are taking a medication that is clearly associated with reduced levels of Coenzyme Q10 in plasma and tissue. The statin medications’ inhibition of the synthesis of cholesterol blocks the same biological pathway that produces Coenzyme Q10 [Littarru 2007].
Statins also have the unfortunate side effect of reducing the body’s production of selenoproteins [Okuyama].
Ironically, we may find out that the statin medications, while effective at lowering Cholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... Read more about this term levels and at reducing the number of heart attacks, have been contributing to the epidemic of The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term and Atherosclerosis is the thickening of the artery walls brought about by the build-up of plaque (plaque is made up of cholesterol and other fatty substances and waste products and calcium and fibrin) and the subsequent slowing of the flow of blood through the clogged arteries. More research is needed into the role of Coenzyme Q10 in the prevention and adjunct... Read more about this term that has occurred during the same period that patients have been taking statin medications.
Drs. Okuyama and Langsjoen have proposed that the guidelines for the prescription of statin medications be re-evaluated .
The study design and the study sample
Dr. Deichmann and his team recruited 19 athletes (15 men and 4 women) with an average age of 64 years (range: 50 – 79 years) to a randomized, double-blind, placebo-controlled cross-over study. The participants’ body mass index was, on average, 24.7 kilograms per square meter [Deichmann 2012].
The study participants were randomly assigned to take the 200-milligram Coenzyme Q10 supplement or the placebo for six weeks. There followed a washout period of six weeks. Then there came a six-week period in which the alternative treatment was administered to the two groups.
The study objectives
The primary outcome measured in the study was the extent to which Coenzyme Q10 was superior to placebo in improving anaerobic threshold (AT), measured by cardiopulmonary exercise testing.
The anaerobic threshold is, roughly defined, that level of exertion that results in an individual’s needing to switch from aerobic (oxygen-burning) energy production to anaerobic (non-oxygen-burning) energy production.
AT is the level of exertion at which the lactate builds up in the muscles during anaerobic energy production faster than the blood can clear it away, with the result that the muscles start to feel tired.
The study results of the Coenzyme Q10 supplementation
Daily supplementation with 200 milligrams of Coenzyme Q10 significantly improved the older athletes’ performance on two measures:
- Time to anaerobic threshold
- Muscle strength
Moreover, the researchers noted multiple trends towards improvement in several of the study’s secondary endpoints; however, these trends did not quite reach the level of statistical significance. The researchers speculated that, given a larger sample, the trends might have reached statistical significance [Deichmann 2012].
Individual variations in responses to Coenzyme Q10
The researchers noted that some of the older athletes showed a more pronounced responsiveness to the administration of Coenzyme Q10 than others did. The differences in response to oral supplementation with Coenzyme Q10 were not associated with the older athletes’ age, gender, or type of athletic activity. Rather, the researchers thought, the degree of responsiveness might be related to the degree of decreased Coenzyme Q10 bio-synthesis.
Furthermore, they thought that the older athletes who were more deficient in Coenzyme Q10 bio-synthesis might well be the older active adults and athletes who are most at risk for:
- statin-induced muscle pain and muscle fatigue
- declining exercise performance
- for The Mayo Clinic defines heart failure, also known as congestive heart failure and/or chronic heart failure, as the failure of the heart muscle to pump blood to the body adequately. In other words, heart failure is not a heart attack, and it is not death from heart disease, which its name might seem to imply. Heart failure is a condition... Read more about this term
Treatment of patients and athletes on statin medications with Coenzyme Q10 is affordable, is free of any significant adverse effects, and is a benign method of preventing and/or reversing statin-induced dysfunction of cellular energy production processes and statin-induced muscle injury.
Supplementation with Coenzyme Q10 is also a good adjunctive treatment for the prevention and amelioration of chronic heart failure.
Deichmann, R. E., Lavie, C. J., & Dornelles, A. C. (2012). Impact of coenzyme Q-10 on parameters of cardiorespiratory fitness and muscle performance in older athletes taking Statins are a class of medications that effectively block the body’s synthesis of cholesterol. In so doing, statins also block the body’s synthesis of Coenzyme Q10.... Read more about this term. The Physician and Sportsmedicine, 40(4), 88-95.
Kalén, A., Appelkvist, E. L., & Dallner, G. (1989). Age-related changes in the lipid compositions of rat and human tissues. Lipids, 24(7), 579-584.
Littarru, G. P., & Langsjoen, P. (2007). Coenzyme Q10 and statins: biochemical and clinical implications. Mitochondrion, 7 SupplS168-S174.
Okuyama, H., Langsjoen, P. H., Hamazaki, T., Ogushi, Y., Hama, R., Kobayashi, T., & Uchino, H. (2015). Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Review of Clinical Pharmacology, 8(2), 189-199.
Rosenfeldt, F., Hilton, D., Pepe, S., & Krum, H. (2003). Systematic review of effect of coenzyme Q10 in physical exercise, Hypertension is abnormally high blood pressure, usually defined as adult systolic blood pressure above 140 mm Hg or adult diastolic blood pressure above 90 mm Hg. Systolic blood pressure is blood pressure measured during the contracting (pumping) of the left ventricle of the heart. Diastolic blood pressure is blood pressure measured during the relaxation of the left ventricle. A meta-analysis... Read more about this term and heart failure. Biofactors (Oxford, England), 18(1-4), 91-100.
Rosenfeldt, F., Marasco, S., Lyon, W., Wowk, M., Sheeran, F., Bailey, M., & … Pepe, S. (2005). Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. The Journal of Thoracic and Cardiovascular Surgery, 129(1), 25-32.
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