Okay, yes, we have to admit to ourselves that high blood pressure is a big problem in our society. “The silent killer,” the doctors call it.
What about using a well-absorbed Coenzyme Q10 molecules are fat-soluble molecules that are both bsynthesized in the body and ingested in the diet and in supplements. Coenzyme Q10 is synthesized in the body in the same biological pathway as cholesterol. Bio-synthesis of Coenzyme Q10 begins to decline once humans reach their adult years. The reduced production of Coenzyme Q10 cannot be compensated in any practical... Read more about this term supplement? What might ts impact on Hypertension is abnormally high blood pressure, usually defined as adult systolic blood pressure above 140 mm Hg or adult diastolic blood pressure above 90 mm Hg. Systolic blood pressure is blood pressure measured during the contracting (pumping) of the left ventricle of the heart. Diastolic blood pressure is blood pressure measured during the relaxation of the left ventricle. A meta-analysis... Read more about this term be? What, exactly, do we know at present?
A good starting point is the meta-analysis done in 2007 by Professor FL Rosenfeldt and his colleagues (1). They set themselves the task of examining all published results from clinical trials involving the use of Q10 with patients with high blood pressure. They wanted to assess the efficacy and consistency of the Q10 treatment. Furthermore, they wanted to identify any side effects of the Q10 treatment.
12 clinical trials with Coenzyme Q10 as the intervention
Rosenfeldt’s group found 12 clinical trials comprising in all 362 patients, of which three were Randomized controlled trials are studies in which patients or healthy volunteers are assigned at random (purely by chance) to receive one or more clinical interventions. One or more of the interventions is the active treatment being tested. Another of the interventions is the control against which the active treatment is being tested. The control is, typically, the standard practice or... Read more about this term, comprising 120 patients, one was a cross-over study, and eight were open-label studies.
In the three randomized controlled trials, the most valid form of Clinical trials are research studies in which various treatments, interventions, or tests are investigated for their safety and efficacy when used to detect, prevent, or treat diseases and medical conditions in patients and healthy volunteers. The gold standard for clinical trials are randomized, double-blind, placebo-controlled studies.... Read more about this term, the results showed The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant.... Read more about this term declines in both systolic blood pressure and diastolic blood pressure following treatment with CoQ10. At the same time, there was no The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... Read more about this term change in the blood pressure of the individuals in the placebo groups.
This is really good news. This is relevant.
Similarly, in the cross-over study, statistically significant declines in blood pressure were seen in the Q10 treatment phase of the study while no significant change was seen in the placebo phase.
There were a total of 214 patients in the eight open-label studies. Also in the aggregate of these studies, there were statistically significant reductions of blood pressure values in the Q10 treatment groups.
Coenzyme Q10 a therapy to reduce blood pressure
Rosenfeldt and his colleagues concluded that Q10 should be considered a therapy to reduce both systolic and diastolic blood pressure in patients with hypertension.
In 2009, Professor M.J. Ho and colleagues did an analysis of three randomized placebo-controlled A double-blind study is a study in which neither the investigators nor the study participants know which participants are receiving the active treatment and which participants are receiving the control treatment until the study has been completed and the seal on the code has been broken.... Read more about this term studies enrolling 96 patients with primary hypertension (2). They found that treatment with Q10 resulted in a statistically significant reduction in both systolic and diastolic blood pressure in these three studies. However, Ho left open the question of whether Q10 can be used to reduce blood pressure in patients with primary hypertension in the long term.
Syndrome X and Coenzyme Q10
Then, in 2012, in a related and relevant study, Young et al did a 12-week clinical trial with 30 patients diagnosed with Metabolic syndrome is the medical term for a cluster of conditions such as excess body fat around the waist, high blood sugar, high blood pressure, high cholesterol or triglyceride levels. Metabolic syndrome is associated with increased risk of diabetes, heart disease, and stroke. Individuals with metabolic syndrome are at higher risk of heart disease, diabetes, and stroke and have, therefore,... Read more about this term (3).. Metabolic syndrome is sometimes known as Syndrome X. It is the term used to describe the condition of patients with not only hypertension but also with abnormal Cholesterol is one of the major fat-soluble compounds that is found in animal plasma membranes. It is necessary for life and is found throughout the body. It is carried from the liver to the tissues where it is needed by lipoproteins of which it is a component. Much of the cholesterol is transported in Low density lipoproteins (LDL). High levels... Read more about this term, with insulin resistance, and with increased risk of blood clotting.
Syndrome X is a condition that can result in heart disease. As such, it is a condition that can be seen to be “hypertension with complications.” WebMD.com estimates that between 20% and 30% of the adults living in industrialized countries could have metabolic syndrome.
In the Young study, the reductions in blood pressure in the Q10 treatment arm of the study were not statistically significant when compared with the results in the placebo arm. Given these results, Young was not able to recommend Q10 as an adjunctive therapy for hypertensive patients with metabolic syndrome, at this time.
Demonstrated safety of Coenzyme Q10
All three studies reported here — the Rosenfeldt study, the Ho Study, and the Young study — did find that the Q10, typically in doses of 200 mg per day, taken twice daily with meals, was very well tolerated and was not associated with any clinically relevant safety issues.
Common sense to use Coenzyme Q10
With the demonstrated safety of Q10 and with the potential benefits of Q10 therapy in mind, doesn’t it seem sensible for people with high blood pressure to approach their physicians to ask permission to take Q10 as an adjuvant treatment for a period of at least 12 weeks? Why not see if the Q10 can make a difference.
- Rosenfeldt, FL et al. Coenzyme Q10 in the Treatment of Hypertension: A Meta-Analysis of the Clinical Trials. Journal of Human Hypertension, 2007, 21: 297-306.
- Ho, MJ et al. Blood Pressure Lowering Efficacy of Coenzyme Q10 for Primary Hypertension. The Cochrane Database of Systematic Reviews, 2009, 4: CD007435.
- Young, JM et al. A Randomized, Double-Blind, Placebo-Controlled Crossover Study of Coenzyme Q10 Therapy in Hypertensive Patients with the Metabolic Syndrome. American Journal of Hypertension, 2012, 25(2): 261-270.