What about infertility problems and Coenzyme Q10, I was asked the other day. Mightn’t the improvement of cellular energy production and the protection against oxidative stress that Coenzyme Q10 supplements give, mightn’t they also help sperm quality and sperm motility? What about Coenzyme Q10 help for the quality of female egg cells?
Coenzyme Q10 and male infertility
Nature Reviews: Urology
In 2011, Dr. Annette Fenner, chief editor at Nature Reviews: Urology, published a note to the effect that supplementation with Coenzyme Q10 improves semen quality parameters and that the improvement in the sperm has been seen to be associated with improved pregnancy rates and live birth rates [Fenner].
Randomized controlled trial results
Italian study: Coenzyme Q10 and sperm motility
In 2009, Italian researchers at the School of Medicine, University of Ancona, in Italy, published the results of a randomized controlled trial. Their research results confirmed the effectiveness of Coenzyme Q10 supplements in improving the quality of sperm in men diagnosed with infertility of unknown origin [Balercia].
Daily supplementation with 200 milligrams of Coenzyme Q10 significantly increased the Coenzyme Q10 concentrations in seminal plasma and in sperm cells and significantly improved sperm motility.
Sperm motility = the measurement of the ability of the sperm to swim forward towards the egg to be fertilized.
Dr. Balercia and the Italian research team concluded that the study results indicate a cause-effect relationship between Coenzyme Q10 levels and sperm motility.
Iranian study: Coenzyme Q10 and sperm density and motility
In 2012, Dr. Safarinejad and a research team at the Clinical Center for Urological Disease Diagnosis, Tehran, Iran, published the results of a randomized controlled trial in which the treatment group of infertile males received 200 milligrams of supplemental Coenzyme Q10 for 26 weeks.
At the end of the 26 weeks, the sperm density and the sperm motility had increased significantly in the Coenzyme Q10 treatment group. The quantity of sperm with abnormal shapes declined significantly in the Coenzyme Q10 treatment group compared with the placebo group [Safarinejad].
Israeli study: Coenzyme Q10 and improved fertilization rates
In 1997, Dr. Lewin and Dr. Lavon, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical School, Jerusalem, Israel, treated infertile males daily with 60 milligrams of a Coenzyme Q10 nutritional supplement for 103 days on average. They noted a The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... Read more about this term improvement in the treated group’s fertilization rates.
The Israeli researched concluded that daily Coenzyme Q10 supplementation may improve sperm parameters in selective patients. They attributed the beneficial effect of the Coenzyme Q10 supplementation to improvement of the energy-dependent processes in the sperm cells and to the Antioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term prevention of Oxidation is the chemical reaction of a substance with oxygen. Peroxidation is the extreme form of oxidation that results from free radicals’ stealing electrons from lipids, either in the cell membranes or in the lipoproteins. The final product of lipid peroxidation is highly reactive malondialdehyde, a bio-marker for oxidative stress and damage.... Read more about this term in sperm membranes [Lewin].
Coenzyme Q10 and female infertility
Canadian study: Coenzyme Q10 and female egg cells
First, researchers in Canada did studies that showed that Coenzyme Q10 supplementation of aging female mice reduced the depletion of the ovarian reserve and improved oocyte quality. The result of the Coenzyme Q10 supplementation was that the aging female mice ovulated more oocytes, their oocytes had improved developmental potential, and they gave birth to more pups [Ben-Meir].
Ovarian reserve = the extent to which the ovary can produce healthy eggs cells that can be fertilized
Oocytes = immature female reproductive cells from which the eggs to be fertilized develop
Then, the Canadian researchers did tests with middle-aged human females to see if the age-related decline in the quality and quantity of their oocytes would be reversed by Coenzyme Q10 supplementation. The researchers knew that humans, starting in their 30’s, begin to synthesize less Coenzyme Q10 and that the reduced endogenous supply of Coenzyme Q10 cannot be replaced by diet alone. Supplementation is necessary. The researchers knew, moreover, that the onset of the age-related decline in Coenzyme Q10 levels coincides with the declines in human female fertility.
The Canadian results indicated that Coenzyme Q10 supplementation improves the quality and quantity of the human female oocytes and improves the ovarian follicle pool [Ben-Meir].
Coenzyme Q10 supplementation safe and affordable
Women in their 30s and 40s who are having difficulty becoming pregnant may want to try Coenzyme Q10 supplements. The Coenzyme Q10 supplements are safe, they are affordable, and they may well help with pregnancy.
Coenzyme Q10: Energy production and antioxidant protection
The mechanism by which Coenzyme Q10 supplementation improves female fertility may be twofold: Coenzyme Q10 improves cellular energy production processes, and Coenzyme Q10 performs an antioxidant function that reduces the extent of cellular oxidative damage.
Balercia, G., Buldreghini, E., Vignini, A., Tiano, L., Paggi, F., Amoroso, S., & Littarru, G. (2009). Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, A double-blind study is a study in which neither the investigators nor the study participants know which participants are receiving the active treatment and which participants are receiving the control treatment until the study has been completed and the seal on the code has been broken.... Read more about this term randomized trial. Fertility and Sterility, 91(5), 1785-1792.
Ben-Meir, A., Burstein, E., Borrego-Alvarez, A., Chong, J., Wong, E., Yavorska, T., & Jurisicova, A. (2015). Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell, 14(5), 887-895.
Fenner, A. (2011). Male factor infertility: coenzyme Q₁₀ improves semen quality and pregnancy rate. Nature Reviews. Urology, 9(1), 2.
Lewin, A., & Lavon, H. (1997). The effect of coenzyme Q10 on sperm motility and function. Molecular Aspects of Medicine, 18 SupplS213-S219.
Safarinejad, M. R., Safarinejad, S., Shafiei, N., & Safarinejad, S. (2012). Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. The Journal of Urology, 188(2), 526-531.
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