Pilot study news: A new study shows that Coenzyme Q10 supplementation reduces depression and fatigue in multiple sclerosis patients. This is good news indeed. Moreover, these are research results that make sense.
We know that Coenzyme Q10 supplementation improves the symptoms of both Chronic fatigue syndrome (CFS) is a complicated disorder with an unknown cause. CFS is characterized by persistent fatigue that does not improve with rest and that cannot be explained by any identifiable medical condition. CFS is also known as myalgic encephalomyelitis (ME) and systemic exertion intolerance disease (SEID). It is sometimes abbreviated ME/CFS. CFS patients typically have low levels of... Read more about this term patients [Castro-Marrero 2016] and Fibromyalgia is characterized by widespread muscle and bone pain. The pain is accompanied by fatigue, sleep, memory problems, and mood issues. Fibromyalgia seems to amplify the brain's processing of painful signals and sensations. Whereas the emphasis in chronic fatigue syndrome is on the persistent fatigue, the emphasis in fibromyalgia is on the widespread pain. Some studies have shown that CoQ10... Read more about this term patients [Cordero 2013]. At least one study has shown that Coenzyme Q10 supplementation improves the symptoms of depression [Forester 2012].
Coenzyme Q10 has anti-inflammatory and anti-oxidative stress properties [Alehagen 2015]. Inflammation is an immune system response to an injury to cells or tissues. It is the body’s attempt to defend against invaders such as bacteria andviruses and to mend the damage done by invaders. Typically, inflammation manifests itself in the form of fever and swelling, in the swarming of white blood cells and the release of cytokines to fight against... Read more about this term and oxidative stress often accompany depression and fatigue.
The anti-inflammatory and Antioxidants are substances that protect the cells and lipoproteins against the harmful effects of free radicals. They are substances that prevent the oxidation of other molecules and compounds. There are two broad categories of antioxidants: enzymatic and non-enzymatic. Non-enzymatic antioxidants are substances like Coenzyme Q10, vitamin C, vitamin E, glutathione, and various carotenoids. Prominent enzymatic antioxidants include catalase, glutathione peroxidase,... Read more about this term activity of Coenzyme Q10 may be the factor responsible for the anti-depression and anti-fatigue effects of the supplementation [Sanoobar 2016].
Coenzyme Q10 and depression and fatigue in MS patients
What was the design of the Sanoobar study of the effect of Coenzyme Q10 supplementation on depression and fatigue in MS patients?
Randomized controlled trial of Coenzyme Q10 supplementation and MS
First of all, the Sanoobar study was a randomized, A double-blind study is a study in which neither the investigators nor the study participants know which participants are receiving the active treatment and which participants are receiving the control treatment until the study has been completed and the seal on the code has been broken.... Read more about this term, placebo-controlled study. It was designed to eliminate as many sources of misleading bias as possible.
The study participants in the Coenzyme Q10 and MS study
48 patients diagnosed with MS were randomly assigned to an active Coenzyme Q10 treatment group or to a matching placebo group, 24 patients in each group. 22 of the 24 patients in the Coenzyme Q10 completed the study; 23 of the 24 patients in the placebo group completed the study.
The patients were predominantly women; there were only two men in each group.
The average age of the patients in the Coenzyme Q10 group was 33 ± 7 years. In the placebo group, the patients averaged 30 ± 7 years.
The average duration of the disease in the study participants was 5 years.
For obvious reasons, the researchers excluded the following categories of MS patients from participation in the study:
- MS patients taking antioxidant supplements
- MS patients taking vitamin and mineral supplements
- MS patients taking anti-depressants
- MS patients taking fatigue modulating drugs
Duration of the Coenzyme Q10 and MS study
The study lasted 12 weeks. At the beginning of the study and then again after 12 weeks of supplementation, the researchers evaluated the patients using the Beck Depression Inventory and the Fatigue Severity Scale.
Dosage used in the Coenzyme Q10 and MS study
The researchers administered a daily dosage of 500 milligrams of Coenzyme Q10 to the patients in the active treatment group.
Their decision to use 500 milligrams daily was influenced by earlier research that had shown the following results:
- 60 milligrams of Coenzyme Q10 per day was too little to improve antioxidant activity [Lee 2012].
- 150 milligrams of Coenzyme Q10 per day did reduce levels of inflammation and did improve antioxidant activity in patients with coronary artery disease [Lee 2012].
- 400 milligrams of Coenzyme Q10 per day reduced the severity of depression symptoms in elderly adults with geriatric bipolar depression [Forester 2012].
In two separate journal articles, Dr. Sanoobar and his colleagues published results documenting the beneficial health effects of taking 500 milligrams of Coenzyme Q10 daily for 12 weeks:
- decreased levels of bio-markers for inflammation
- decreased levels of bio-markers for oxidative stress
- increased levels of the antioxidant enzymes catalase, superoxide dismutase, and glutathione peroxidase [Sanoobar 2016]
Results of the Coenzyme Q10 and MS study
The analysis of the data from the Beck Depression Inventory and the Fatigue Severity Scale showed The outcome of a clinical trial is thought to have statistical significance, or to be statistically significant, if the outcome is likely not caused by chance at a given statistical significance level, typically at the 0.05 level. Statistically significant outcomes may or may not be clinically significant. ... Read more about this term decreases in depression and fatigue scores in the Coenzyme Q10 treatment group as compared to the placebo group [Sanoobar 2016].
A well-formulated and tested Coenzyme Q10 supplement has much to recommend it:
- It is safe and effective.
- It is simple to take
- It is inexpensive.
- It is necessary to replace the age-related loss of endogenous Coenzyme Q10.
Alehagen, U., Lindahl, T.L., Aaseth, J., Svensson, E., Johansson, P. (2015). Levels of sPselectin and hs-CRP decrease with dietary intervention with Selenium (symbol Se, atomic number 34) is a trace element that is an essential nutrient and an essential component of some of the most important antioxidants in the body, in particular the selenoproteins glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenium is involved in the optimal functioning of the immune system. Professor Alehagen has pointed out that there exists a... Read more about this term and Coenzyme Q10 combined: a secondary analysis of a randomized Clinical trials are research studies in which various treatments, interventions, or tests are investigated for their safety and efficacy when used to detect, prevent, or treat diseases and medical conditions in patients and healthy volunteers. The gold standard for clinical trials are randomized, double-blind, placebo-controlled studies.... Read more about this term. PLoS ONE 10(9): e0137680. doi:10.1371/journal.pone.0137680
Castro-Marrero, J., Sáez-Francàs, N., Segundo, M. J., Calvo, N., Faro, M., Aliste, L., & Alegre, J. (2016). Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial. Clinical Nutrition (Edinburgh, Scotland), 35(4), 826-834.
Cordero, M. D., Alcocer-Gómez, E., de Miguel, M., Culic, O., Carrión, A. M., Alvarez-Suarez, J. M., & Sánchez-Alcazar, J. A. (2013). Can Coenzyme Q10 improve clinical and molecular parameters in fibromyalgia? Antioxidants & Redox Signaling, 19(12), 1356-1361.
de Bustos, F., Jiménez-Jiménez, F. J., Molina, J. A., Gómez-Escalonilla, C., de Andrés, C., del Hoyo, P., & … Arenas, J. (2000). Serum levels of coenzyme Q10 in patients with multiple sclerosis. Acta Neurologica Scandinavica, 101(3), 209-211.
Forester, B. P., Zuo, C. S., Ravichandran, C., Harper, D. G., Du, F., Kim, S., & … Renshaw, P. F. (2012). Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression. Journal of Geriatric Psychiatry And Neurology, 25(1), 43-50. doi:10.1177/0891988712436688
Lee, B., Huang, Y., Chen, S., & Lin, P. (2012). Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition (Burbank, Los Angeles County, Calif.), 28(3), 250-255. doi:10.1016/j.nut.2011.06.004
Sanoobar, M., Dehghan, P., Khalili, M., Azimi, A., & Seifar, F. (2016). Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial. Nutritional Neuroscience, 19(3), 138-143. doi:10.1179/1476830515Y.0000000002
Sanoobar, M., Eghtesadi, S., Azimi, A., Khalili, M., Khodadadi, B., Jazayeri, S., & Aryaeian, N. (2015). Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial. Nutritional Neuroscience, 18(4), 169-176. doi:10.1179/1476830513Y.0000000106
Sanoobar, M., Eghtesadi, S., Azimi, A., Khalili, M., Jazayeri, S., & Reza Gohari, M. (2013). Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. The International Journal of Neuroscience, 123(11), 776-782. doi:10.3109/00207454.2013.801844
Zahednasab, H., Mesbah-Namin, S. A., & Balood, M. (2015). Coenzyme Q10 supplementation and multiple sclerosis. Nutritional Neuroscience, 18(4), 192. doi:10.1179/1476830514Y.0000000126
Disclaimer: The information presented in this review article is not intended as medical advice and should not be construed as such.Please click here for additional information about the health benefits of Coenzyme Q10 supplementation.